Abstract A pilot cross sectional study was conducted to investigate the role of red blood cells (RBC) deformability in type 2 diabetes mellitus (T2DM) without and with diabetic retinopathy (DR) using a dual optical tweezers stretching technique. made by splitting recombining single Nd:YAG laser beam. RBCs were trapped directly (i.e., microbead handles) where they observed adopt “side-on” orientation. RBC initial final lengths after measured digital video microscopy Deformability index (DI)...

Abstract Pyotr Kapitza studied in 1951 the unusual equilibrium features of a rigid pendulum when its point suspension is under high-frequency vertical vibration. A sufficiently fast vibration makes top position stable, putting an inverted orientation that seemingly defies gravity. Kapitza’s analytical method, based on asymptotic separation and slow variables yielding renormalized potential, has found application many diverse areas. Here we study going beyond typical idealizations, by...

Diabetic retinopathy (DR) is a microvascular complication of diabetes mellitus (DM) in which high blood sugar levels cause swelling, leaking and occlusions the vessels retina, often resulting loss sight. The system requires red cells (RBCs) to undergo significant cellular deformation order pass through whose diameters are significantly smaller than their own. There evidence suggest that DM impairs deformability RBCs, this has been associated with diabetic kidney disease (or nephropathy) -...

353 Background: Everolimus and temsirolimus are mammalian target of rapamycin (mTOR) inhibitors used in a variety malignancies including renal cell carcinoma (RCC). These targeted agents have been associated with unique set adverse events infections. We performed an up-to-date meta-analysis published clinical trials to further characterize the risk infections cancer patients treated mTOR inhibitors. Methods: Pubmed oncology conference proceedings were searched for studies from January 1966...

Purpose: To investigate differences in red blood cell (RBC) deformability between birdshot chorioretinopathy (BCR) subjects and matched controls, to postulate its relationship with lack of vascular occlusion BCR. Methods: In a single center, prospective, non-randomized mechanistic study, samples were collected from eight healthy controls nine BCR patients, subjected biochemical hematological tests, as well RBC indices assessment using dual-beam optical tweezers. Results: The mean age the was...

We present a study of dynamical stabilisation an overdamped, microscopic pendulum realised using optical tweezers. first derive analytical expression for the equilibrium dynamically stabilised position in regime high damping and modulation frequency pivot. This model implies threshold behavior to occur, continuous evolution angular which, unlike underdamped case, does not reach fully inverted position. then test theoretical predictions optically trapped microparticle subject fluid drag...

316 Background: Sunitinib is a multitargeted receptor tyrosine kinase inhibitor that widely used in the treatment of renal cell cancer (RCC) and several other malignancies. Congestive heart failure (CHF) has been reported with sunitinib, but overall incidence relative risk (RR) remain undefined. We preformed an up-to-date comprehensive meta-analysis to determine developing serious CHF patients both RCC non-RCC tumors treated sunitinib. Methods: Medline databases were searched for articles...

349 Background: Vascular endothelial growth factor receptor (VEGFR) tyrosine kinase inhibitors (TKIs) have become the cornerstone in treatment of several malignancies. These drugs also been associated with an increase risk potentially life-threatening adverse events, such as arterial thrombotic bleeding, congestive heart failure, and others. We performed up-to-date meta-analysis to determine fatal events (FAEs) patients cancer treated VEGFR TKIs. Methods: MEDLINE PubMed databases were...

It is well known that a rigid pendulum with minimal friction will occupy stable equilibrium position vertically upwards when its suspension point oscillated at high frequency. The phenomenon of the inverted was explained by Kapitza invoking separation timescales between frequency modulation and much lower motion, resulting in an effective potential minimum position. We present here study microscopic optical analogue Kapitza's operates different regimes both driving realized using particle...

We present a study of correlated Brownian fluctuations between optically confined particles in number different configurations. First we colloidal held separate optical tweezers. In this configuration the are known to interact through their hydrodynamic coupling, leading pronounced anti-correlation position at short times. system and behavior motion when trapped subject an external force such as viscous drag. The second considered is chain bound evanescent wave surface trap. both coupling....

In this work we report on experiments to measure the deformability of red blood cells (RBCs) when subject stretching with optical tweezers. Individual are trapped directly in a dual tweezers, and protocol that is same for all under test. Differences resulting extension therefore indicative differences cell deformability. The targets investigation RBCs taken from patients type 2 diabetes mellitus (T2DM) who exhibit diabetic retinopathy (DR), birdshot chorioretinopathy (BCR). We find...

The Kapitza pendulum is the paradigm for phenomenon of dynamical stabilization, whereby an otherwise unstable system achieves a stability that induced by fast modulation control parameter. In classic, macroscopic pendulum, rigid stabilized in upright, inverted using particle confined ring-shaped optical trap, subject to drag force via fluid flow and driven oscillating potential direction parallel flow. regime vanishing Reynold's number with high-frequency driving no longer stable, but new...

Abstract Background Pulmonary infections associated with Mycobacterium avium complex can be challenging to treat medically and the role of surgical lung resection is not well established. We aim assess safety microbiologic response in patient localized pulmonary managed compared medical management alone. Methods present a multi-institutional case series 16 patients resection. highlight 30 40-year-old disease amenable for illustrative purposes report on outcomes treated at same institution...