A5102900685- Dementia and Cognitive Impairment Research
- Alzheimer's disease research and treatments
- Frailty in Older Adults
- Neurobiology of Language and Bilingualism
- Technology Use by Older Adults
- Geriatric Care and Nursing Homes
- Sharing Economy and Platforms
- Genetic Associations and Epidemiology
- Mobile Health and mHealth Applications
- Palliative Care and End-of-Life Issues
- Dental Health and Care Utilization
- Cerebrovascular and Carotid Artery Diseases
- Health disparities and outcomes
- Telemedicine and Telehealth Implementation
- Digital Platforms and Economics
- Ethics in Clinical Research
- Health, Environment, Cognitive Aging
- Neurological Disease Mechanisms and Treatments
- Balance, Gait, and Falls Prevention
- Transportation and Mobility Innovations
- Neural dynamics and brain function
- Blood Pressure and Hypertension Studies
- Global Health and Surgery
- Patient-Provider Communication in Healthcare
- Cerebrovascular and genetic disorders
Icahn School of Medicine at Mount Sinai
2014-2024
Harvard University Press
2023
Mount Sinai Hospital
2015
Agriculture Fisheries and Conservation Department
2009
Abstract INTRODUCTION Clinical research in Alzheimer's disease (AD) lacks cohort diversity despite being a global health crisis. The Asian Cohort for Disease (ACAD) was formed to address underrepresentation of Asians research, and limited understanding how genetics non‐genetic/lifestyle factors impact this multi‐ethnic population. METHODS ACAD started fully recruiting October 2021 with one central coordination site, eight recruitment sites, two analysis sites. We developed comprehensive...
Subjective cognitive decline (SCD) is recognized to be in the Alzheimer disease (AD) continuum. The SCD Initiative International Working Group recently proposed SCD-plus (SCD+) features that increase risk for future objective but have not been assessed a large community-based setting.
Background:Subjective cognitive complaint is a sensitive marker of decline. Objective:This study aimed to (1) examine reliability subjective using the Cognitive Function Instrument (CFI), and (2) assess utility CFI detect decline in non-demented elders . Methods:Data from four-year longitudinal at multiple Alzheimer's Disease Cooperative Study (ADCS) sites were extracted (n = 644). Of these, 497 had Clinical Dementia Rating (CDR) global scores 0 147 CDR 0.5. Mean age education 79.5±3.6...
Identification and quantification of fibrillar amyloid in brain using positron emission tomography (PET) imaging Amyvid™ ([18 F] Amyvid, [18 florbetapir, 18 F-AV-45) was recently approved by the US Food Drug Administration as a clinical tool to estimate burden patients being evaluated for cognitive impairment or dementia. Imaging with florbetapir offers vivo confirmation presence cerebral amyloidosis may increase accuracy diagnosis likely cause (CI) Most importantly, improve certainty...
Objective: In New York City in 2020 the pandemic shut down in-person research. Icahn School of Medicine’s Alzheimer’s Disease Research Center transitioned longitudinal evaluations from to telephone enhance equity access. We assessed diverse research participants’ and clinical coordinators’ (CRC) satisfaction with remote evaluation examined sociodemographic, cognitive, behavioral factors that might impact satisfaction. Methods: Data collected: 241 participants Clinical Dementia Rating (CDR) =...
Intensive surveillance of dead wild birds for H5N1 avian influenza infection is conducted in Hong Kong. Between January 2006 and October 2007 pooled cloacal tracheal swabs from 17692 (from 16 different orders including 82 genera) were tested 33 highly pathogenic viruses isolated. No has occurred poultry farms since 2003, or live markets Kong November 2003 until a recent detection virus by June 2008. The gross histopathology the various H5N1-infected species described, along with performance...
We study the behavior of an economic platform (e.g., Amazon, Uber Eats, Instacart) under shocks, such as COVID-19 lockdowns, and effect different regulation considerations. To this end, we develop a multi-agent simulation environment economy in multi-period setting where shocks may occur disrupt economy. Buyers sellers are heterogeneous modeled economically-motivated agents, choosing whether or not to pay fees access platform. use deep reinforcement learning model fee-setting matching...
Little is known about factors affecting motivation and satisfaction of participants in dementia prevention trials.A Research Satisfaction Survey was administered to 422 nondemented older adults who participated the Home-Based Assessment trial.Overall high, with means all individual items near above a value 3 on scale from 1 (worst) 4 (best). Greater associated staff-administered interviews versus automated technologies. The most liked aspects research participation were volunteerism,...
Objective: This study aims to evaluate the performance of a Chinese version Montreal Cognitive Assessment (MoCA) as screener detect mild cognitive impairment (MCI) and dementia from normal cognition in monolingual Chinese-speaking immigrant population. Method: A cohort 176 older adults National Alzheimer’s Coordinating Center Uniform Data Set is used for analysis. We explore impact demographic variables on MoCA calculate optimal cutoffs detection MCI with appropriate adjustment. Results:...
Purpose: This study described and evaluated the rapid recruitment of elderly Chinese into clinical research at Mount Sinai Alzheimer’s Disease Research Center (MSADRC). Design Methods: Methods publicizing included lectures to local senior centers/churches publications in newspapers. The amount time success these methods were evaluated. A “go them” model evaluation was used enable participants complete visit locations where they comfortable. Results: From January December 2015, we recruited...
Abstract Introduction This pilot study aims to explore the psychometric properties of Cognitive Function Instrument (CFI) as a measure subjective cognitive complaints (SCC) and its performance in distinguishing mild impairment (MCI) from normal control (NC) compared an objective screen (Montreal Assessment [MoCA]). Methods One hundred ninety‐four community‐dwelling non‐demented older adults with racial/ethnic diversity were included. Unidimensionality internal consistency CFI examined using...
ABSTRACT Objectives: This study aimed to determine the diagnostic utility of a Chinese test battery for evaluating cognitive loss in elderly Americans. Methods: Data from pilot at Mount Sinai Alzheimer’s Disease Research Center was examined. All participants were > 65 years old, primarily speaking, with adequate sensorimotor capacity complete tests. A research diagnosis normal mild impairment (MCI) or disease (AD) assigned each participant consensus conference. Composite scores...
Abstract INTRODUCTION Little work has compared the effectiveness of using multiple types memory tests alone or in combination to distinguish dementia severity diverse research cohorts including Black individuals and Spanish speakers. Here we evaluate word list paragraph recall cognitively normal, mild impaired, those with Alzheimer's disease cohorts. METHODS Using Uniform Data Set (UDS) site‐specific supplemental data, logistic regression models receiver operating characteristic–area under...
ABSTRACT Objectives: This study describes the performance of Multilingual Naming Test (MINT) by Chinese American older adults who are monolingual speakers. An attempt was also made to identify items that could introduce bias and warrant attention in future investigation. Methods: The MINT administered 67 as part standard dementia evaluation at Alzheimer’s Disease Research Center (ADRC) Icahn School Medicine Mount Sinai (ISMMS), New York, USA. A diagnosis normal cognition ( n = 38), mild...
The Beijing version of Montreal Cognitive Assessment (B-MoCA) was originally developed for Mandarin speakers but can also be used Cantonese speakers. Our study aimed to evaluate the capability B-MoCA in identifying elderly U.S. Chinese participants with Mild Impairment (MCI) or dementia. We administered test 86 Americans during a standard dementia evaluation as part clinical at Mount Sinai Alzheimer's Disease Research Center (MSADRC). All were primarily speaking and ≥ 65 years old. Clinical...
A 75-year-old Chinese American man presented to behavioral neurology clinic for a second opinion of dementia with Lewy body disease (DLB). The clinical manifestations met the criteria probable DLB diagnosis. Yet, in-depth evaluation unveiled history, family and neuroimaging evidences that suggested diagnosis variant frontotemporal (FTD). heterozygous pathogenic in microtubule-associated protein Tau (MAPT) was identified through genetic testing confirmed autosomal dominant MAPT-related FTD....
Abstract Background Subjective cognitive decline (SCD) is recognized to be in the Alzheimer’s disease (AD) continuum. An international working group known as SCD‐initiative recently proposed “SCD plus” features, including report of memory problems, recent SCD relative conversion, over age 60, and consistent time, that increase risk for future objective decline. These have not been fully assessed a large community‐based setting. Method Participants from all cohorts Framingham Heart Study who...
Abstract Background Socio‐cultural and language‐appropriate study materials instruments are critical for accurate assessment of cognitive function in people from diverse backgrounds. Most research uses tests based on Western, industrialized, English‐speaking cultures may not reflect global experiences. The purpose this was to describe the translations cultural adaptations that were developed Asian Cohort Alzheimer’s Disease (ACAD). Methods Multi‐lingual researchers, clinicians, community...
Abstract Background Vascular disorders are proposed as modifiable risk factors for dementia; yet, physiologic mechanisms connecting vascular to cognitive impairment remain unknown. We examined subclinical cardiovascular measures determine which predict global decline and domain specific point potential pathways linking disease dementia. Methods MESA includes a diverse cohort of 6,814 participants free from clinical with follow‐up over 6 examinations annual calls. At baseline in 2000‐2002, 24...
Abstract Background Environmental pollutants, called perfluoroalkyl substances (PFAS) have been linked to adverse cardiometabolic outcomes, immune dysfunction and cancer risk, but their associations with adult cognition are unknown. Nearly everyone in the United States has detectable levels of PFAS blood, our prior work found that Asian Americans highest exposure burden. As fastest growing segment older adults, examination relationships between serum concentrations urgently needed. Here,...
Abstract Background Asian Americans and Canadians (ASACs) are the fastest growing minority group in US Canada. However, ASACs under‐sampled Alzheimer’s disease (AD) research. To address need of culturally appropriate clinical protocols community‐based recruitment approaches for ASACs, Cohort Disease (ACAD), first large dementia genetics cohort focusing on Chinese, Korean, Vietnamese, launched 2021 to examine genetic non‐genetic risk factors AD among ASACs. Our participatory research (CPBR)...
Abstract Background Data collection by smartphone is becoming more widespread in healthcare research. Previous studies reported racial/ethnical differences the use of digital health technology. However, cross‐language group comparison (Chinese‐ and English‐speaking older adults) were not performed these studies. This project will expand to technology diverse populations with a focus on Chinese American adults who are monolingual Chinese‐speakers. Method The Alzheimer’s Disease Research...