A5071034304- Advanced Glycation End Products research
- Metabolism, Diabetes, and Cancer
- Adipose Tissue and Metabolism
- Adipokines, Inflammation, and Metabolic Diseases
- Lipid metabolism and biosynthesis
- Circadian rhythm and melatonin
- Diabetes Treatment and Management
- Dietary Effects on Health
- Endoplasmic Reticulum Stress and Disease
- Autophagy in Disease and Therapy
- Hyperglycemia and glycemic control in critically ill and hospitalized patients
- Diabetes and associated disorders
- Electrochemical sensors and biosensors
- Neuroinflammation and Neurodegeneration Mechanisms
- Diet and metabolism studies
- Oral health in cancer treatment
- Natural Antidiabetic Agents Studies
- Pancreatic function and diabetes
- Protein Kinase Regulation and GTPase Signaling
- Heme Oxygenase-1 and Carbon Monoxide
- Advanced Nanomaterials in Catalysis
- Cardiovascular Health and Disease Prevention
- Neutropenia and Cancer Infections
- Tryptophan and brain disorders
- Cancer Diagnosis and Treatment
Fundación para el Fomento de la Investigación Sanitaria y Biomédica de la Comunitat Valenciana
2022-2025
Hospital Universitario Doctor Peset
2022-2025
Universitat de València
2022-2025
Uppsala University
2022-2023
INCLIVA Health Research Institute
2022
Type 2 diabetes (T2D) is linked to metabolic, mitochondrial and inflammatory alterations, atherosclerosis development cardiovascular diseases (CVDs). The aim was investigate the potential therapeutic benefits of GLP-1 receptor agonists (GLP-1 RA) on oxidative stress, respiration, leukocyte-endothelial interactions, inflammation carotid intima–media thickness (CIMT) in T2D patients. diabetic patients (255) control subjects (175) were recruited, paired by age sex, separated into two groups:...
Overloaded glucose levels in several metabolic diseases such as type 2 diabetes (T2D) can lead to mitochondrial dysfunction and enhanced production of reactive oxygen species (ROS). Oxidative stress altered homeostasis, particularly the cardiovascular system, contribute development chronic comorbidities diabetes. Diabetes-associated hyperglycemia dyslipidemia directly damage vascular vessels coronary artery disease or stroke, indirectly other organs kidney dysfunction, known diabetic...
Abstract Chemotherapy-induced intestinal mucositis is a severe side effect contributing to reduced quality of life and premature death in cancer patients. Despite high incidence, thorough mechanistic understanding its pathophysiology effective supportive therapies are lacking. The main objective this rat study was determine how 10 mg/kg doxorubicin, common chemotherapeutic, affected jejunal function morphology over time (6, 24, 72, or 168 h). secondary if the type dosing administration...
Gold-ceria nanoparticles (Au/CeO2) are known to have antioxidant properties. However, whether these can provide benefits in type 2 diabetes mellitus (T2D) remains unknown. This work aimed study the effects of Au/CeO2 at different rates gold purity (10, 4.4, 1.79 and 0.82) on leukocyte–endothelium interactions inflammation T2D patients. Anthropometric metabolic parameters, interactions, ROS production NF-κB expression were assessed 57 patients 51 healthy subjects. displayed higher Body Mass...
Type 2 diabetes (T2D) is a long-term metabolic disease characterized by progressive β-cell functional decline and insulin resistance, which increases the risk of cardiovascular complications as well associated-morbidity mortality. Evidence suggests strong relationship between hyperglycaemia, oxidative stress development progression T2D. Indeed, hyperglycaemic state can reduce activity antioxidant enzymes increase lipid peroxidation protein oxidation products, DNA damage. At present,...
Alterations in circadian rhythms increase the likelihood of developing type 2 diabetes and CVD. Circadian are controlled by several core clock genes, which expressed nearly every cell, including immune cells. Immune cells key players pathophysiology diabetes, participate atherosclerotic process that underlies cardiovascular risk these patients. The role leukocytes people with inflammatory associated it unknown. We aimed to evaluate whether molecular system is impaired patients explore...
Objective: Type 2 diabetes (T2D) is linked to metabolic, mitochondrial and inflammatory alterations, atherosclerosis development cardiovascular diseases (CVDs). The aim was investigate the potential therapeutic benefits of GLP-1 receptor agonists (GLP-1 RA) on oxidative stress, respiration, leukocyte-endothelial interactions, inflammation carotid intima–media thickness (CIMT) in T2D patients.Research Design Methods: diabetic patients (255) control subjects (175) were recruited, paired by age...