A5064167770- Lymphatic System and Diseases
- Sympathectomy and Hyperhidrosis Treatments
- MicroRNA in disease regulation
- Cholangiocarcinoma and Gallbladder Cancer Studies
- Ferroptosis and cancer prognosis
- Thyroid Cancer Diagnosis and Treatment
- Cancer Immunotherapy and Biomarkers
- Cerebrospinal fluid and hydrocephalus
- Cancer Mechanisms and Therapy
- Liver Disease Diagnosis and Treatment
- CAR-T cell therapy research
- Cellular Mechanics and Interactions
- Gut microbiota and health
- Planarian Biology and Electrostimulation
- Cancer, Hypoxia, and Metabolism
- Cancer-related Molecular Pathways
- Extracellular vesicles in disease
- Pancreatic and Hepatic Oncology Research
- Genetic and Kidney Cyst Diseases
- Pediatric Hepatobiliary Diseases and Treatments
- Cancer-related molecular mechanisms research
- Ovarian cancer diagnosis and treatment
- Liver physiology and pathology
- Liver Diseases and Immunity
- Immune Cell Function and Interaction
Texas A&M Health Science Center
2014-2025
Assam Agricultural University
2024
Cornell University
2021-2024
Indian Institute of Technology Palakkad
2022-2024
Bryan College
2020-2024
Texas A&M University
2017-2024
Government of West Bengal
2024
Mitchell Institute
2023-2024
University of Exeter
2023
University of Warwick
2023
Abstract Background Despite extensive research, the five-year survival rate of oral squamous cell carcinoma (OSCC) patients has not improved. Effective treatment OSCC requires identification molecular targets and signaling pathways to design appropriate therapeutic strategies. Several genes from mTOR pathway are known be dysregulated in a wide spectrum cancers. However, much is about involvement this tumorigenesis OSCC. We therefore investigated role tumor suppressor genes, TSC1 TSC2 , other...
Insulin resistance is a well-known risk factor for obesity, metabolic syndrome (MetSyn) and associated cardiovascular diseases, but its mechanisms are undefined in the lymphatics. Mesenteric lymphatic vessels from MetSyn or LPS-injected rats exhibited impaired intrinsic contractile activity inflammatory changes. Hence, we hypothesized that insulin muscle cells (LMCs) affects cell bioenergetics signaling pathways consequently alter contractility. LMCs were treated with different...
The lymphatics have emerged as critical players in the progression and resolution of inflammation. goal this study was to identify specific microRNAs (miRNAs) that regulate lymphatic inflammatory processes. Rat mesenteric endothelial cells (LECs) were exposed proinflammatory cytokine tumor necrosis factor-α for 2, 24, 96 h, miRNA profiling carried out by real-time PCR arrays. Our data demonstrate a set miRNAs are differentially expressed (>1.8-fold and/or P < 0.05) LECs response involved...
Impairment of the lymphatic system is apparent in multiple inflammatory pathologies connected to elevated endotoxins such as LPS. However, direct mechanisms by which LPS influences contractility are not well understood. We hypothesized that a dynamic modulation innate immune cell populations mesentery under conditions perturbs tissue cytokine/chemokine homeostasis and subsequently function. used rats were intraperitoneally injected with (10 mg/kg) determine changes profiles cells...
Changes in the abundance of certain bacterial species within colorectal microbiota correlate with cancer (CRC) development. While carcinogenic mechanisms single pathogenic bacteria have been characterized
Muscular lymphatics use both phasic and tonic contractions to transport lymph for conducting their vital functions. The molecular mechanisms regulating lymphatic muscle are not well understood. Based on the well-established finding that phosphorylation of myosin light chain 20 (MLC(20)) plays an essential role in blood vessel smooth contraction, we investigated if phosphorylated MLC(20) (pMLC(20)) would modulate and/or muscle. effects ML-7, a MLC kinase inhibitor (1-10 microM), were tested...
Abstract Objective The intrinsic lymphatic pump is critical to proper lymph transport and impaired in models of the MetSyn. Lymphatic contractile inhibition under inflammatory conditions has been linked with elevated NO production by activated myeloid–derived cells. Hence we hypothesized that MLV function MetSyn animals was dependent on associated altered macrophage recruitment polarization within . Methods We used a high fructose‐fed rat model Macrophage determined whole mount...
Background and Aims Apelin (APLN) is the endogenous ligand of its G protein–coupled receptor, apelin receptor (APJ). APLN serum levels are increased in human liver diseases. We evaluated whether APLN–APJ axis regulates ductular reaction fibrosis during cholestasis. Approach Results measured expression APJ primary sclerosing cholangitis (PSC) samples. Following bile duct ligation (BDL) or sham surgery, male wild‐type (WT) mice were treated with ML221 (APJ antagonist) saline for 1 week. WT −/−...
Abstract Therapy resistance is imposing a daunting challenge on effective clinical management of breast cancer. Although the development to drugs multifaceted, reprogramming energy metabolism pathways emerging as central but heterogenous regulator this therapeutic challenge. Metabolic heterogeneity in cancer cells intricately associated with alterations different signaling networks and activation DNA damage response pathways. Here we consider how dynamic metabolic milieu regulates their...
The renal lymphatic vasculature and the endothelial cells that make up this network play important immunomodulatory roles during inflammation. How lymphatics respond to AKI may affect outcomes. authors used single-cell RNA sequencing characterize mouse in quiescent cisplatin-injured kidneys. Lymphatic cell gene expression changes were confirmed ischemia-reperfusion injury cultured cells, validating data. This study is first describe heterogeneity uncovers molecular pathways demonstrating...
The harmonious convergence of Natural Language Processing (NLP) and Artificial Intelligence (AI) is ushering in a new era transformation within the financial services realm, where art hyper-personalization, elegance emotional AI, foresight predictive analytics are weaving together to craft an experience unparalleled sophistication insight. Hyper-personalization enables platforms analyze real-time data, offering tailored dynamically each customer's changing behaviors preferences. Emotional on...
The most memorable protagonists in any given piece of Classical Literature are often the characters who face and overcome greatest psychological trials obstacles. This article studies choices two such both experience extreme unimaginable sorrow – Homer’s Andromache Shakespeare’s Juliet. While one character is content with her role society, other tries to break convention order be love. A deeper psychoanalytical study their actions choices, particular emphasis on effects ‘sorrow’ through lens...