A5101888344- Liver Diseases and Immunity
- Liver Disease Diagnosis and Treatment
- Liver physiology and pathology
- Circadian rhythm and melatonin
- Pediatric Hepatobiliary Diseases and Treatments
- Mast cells and histamine
- Drug Transport and Resistance Mechanisms
- Metabolism, Diabetes, and Cancer
- Diabetes Treatment and Management
- Pharmacology and Obesity Treatment
- Digestive system and related health
- Eosinophilic Esophagitis
- Liver Disease and Transplantation
- MicroRNA in disease regulation
- Diet, Metabolism, and Disease
- Fibroblast Growth Factor Research
- Alcohol Consumption and Health Effects
- Systemic Sclerosis and Related Diseases
- Glaucoma and retinal disorders
- Eicosanoids and Hypertension Pharmacology
- Organ Transplantation Techniques and Outcomes
- Diet and metabolism studies
- Retinal Diseases and Treatments
- Reproductive System and Pregnancy
- Drug-Induced Hepatotoxicity and Protection
Yunnan Institute of Environmental Sciences
2025
Yuxian People's Hospital
2024
Xian Yang Central Hospital
2024
RELX Group (United States)
2024
Indiana University School of Medicine
2020-2023
Indiana University – Purdue University Indianapolis
2020-2023
Texas A&M University
2018-2022
Richard L. Roudebush VA Medical Center
2020-2022
University of Rome Tor Vergata
2022
Sapienza University of Rome
2022
Importance Red blood cell (RBC) transfusion is common among patients admitted to the intensive care unit (ICU). Despite multiple randomized clinical trials of hemoglobin (Hb) thresholds for transfusion, little known about how these are incorporated into current practice. Objective To evaluate and describe ICU RBC practices worldwide. Design, Setting, Participants International, prospective, cohort study that involved 3643 adult from 233 ICUs in 30 countries on 6 continents March 2019 October...
Background and Aims Cholestasis is characterized by increased total bile acid (TBA) levels, which are regulated farnesoid X receptor (FXR)/FGF15. Patients with primary sclerosing cholangitis (PSC) typically present inflammatory bowel disease (IBD). Mast cells (MCs) (i) express FXR (ii) infiltrate the liver during cholestasis promoting fibrosis. In bile‐duct‐ligated (BDL) MC‐deficient mice (B6.Cg‐ KitW‐sh /HNihrJaeBsmJ [ ]), ductular reaction (DR) fibrosis decrease compared BDL wild type, MC...
Background and Aims Nonalcoholic fatty liver disease (NAFLD) is simple steatosis but can develop into nonalcoholic steatohepatitis (NASH), characterized by inflammation, fibrosis, microvesicular steatosis. Mast cells (MCs) infiltrate the during cholestasis promote ductular reaction (DR), biliary senescence, fibrosis. We aimed to determine effects of MC depletion NAFLD/NASH. Approach Results Wild‐type (WT) KitW‐sh (MC‐deficient) mice were fed a control diet (CD) or Western (WD) for 16 weeks;...
NAFLD is characterized by steatosis, hepatic inflammation, and fibrosis, which can develop into NASH. Patients with NAFLD/NASH have increased ductular reaction (DR) biliary senescence. High fat/high cholesterol diet feeding increases senescence, DR, insulin-like growth factor-1 (IGF-1) expression in mice. p16/IGF-1 converges fork-head box transcription factor O1 (FOXO1) through E2F1. We evaluated p16 inhibition on phenotypes E2F1/FOXO1/IGF-1 signaling.4-week wild-type (C57BL/6J) male mice...
Background and Aims Apelin (APLN) is the endogenous ligand of its G protein–coupled receptor, apelin receptor (APJ). APLN serum levels are increased in human liver diseases. We evaluated whether APLN–APJ axis regulates ductular reaction fibrosis during cholestasis. Approach Results measured expression APJ primary sclerosing cholangitis (PSC) samples. Following bile duct ligation (BDL) or sham surgery, male wild‐type (WT) mice were treated with ML221 (APJ antagonist) saline for 1 week. WT −/−...
Background and Aims Serotonin (5HT) is a neuroendocrine hormone synthetized in the central nervous system (CNS) as well enterochromaffin cells of gastrointestinal tract. Tryptophan hydroxylase (TPH1) monoamine oxidase (MAO‐A) are key enzymes for synthesis catabolism 5HT, respectively. Previous studies demonstrated that 5‐hydroxytryptamine receptor (5HTR)1A/1B agonists inhibit biliary hyperplasia bile‐duct ligated (BDL) rats, whereas 5HTR2B antagonists attenuate liver fibrosis (LF) mice. Our...
Cholangiocytes are the target cells of cholangiopathies including primary sclerosing cholangitis (PSC). Vimentin is an intermediate filament protein that has been found in various types mesenchymal cells. The aim this study to evaluate role vimentin progression biliary damage/liver fibrosis and whether there a phenotype cholangiocytes Mdr2-/- model PSC.In vivo studies were performed 12 wk. male mice with or without Vivo-Morpholino treatment their corresponding control groups. Liver specimens...
Human NAFLD is characterized at early stages by hepatic steatosis, which may progress to NASH when the liver displays microvesicular lobular inflammation, and pericellular fibrosis. The secretin (SCT)/secretin receptor (SCTR) axis promotes biliary senescence fibrosis in cholestatic models through down-regulation of miR-125b signaling. We aim evaluate effect disrupting SCT/SCTR/miR-125b signaling on senescence, NAFLD/NASH.In vivo, 4-week-old male wild-type, Sct-/- Sctr-/- mice were fed a...
Biliary senescence and hepatic fibrosis are hallmarks of cholangiopathies including primary sclerosing cholangitis (PSC). Senescent cholangiocytes display senescence-associated secretory phenotypes [SASPs, e.g., transforming growth factor-1 (TGF-1)] that further increase biliary (by an autocrine loop) trigger liver by paracrine mechanisms. The aim this study was to determine the effect p16 inhibition role TGF-1/microRNA (miR)-34a/sirtuin 1 (SIRT1) axis in damage Mdr2/ mouse model PSC. We...
Abstract Background and Aims Melatonin reduces biliary damage liver fibrosis in cholestatic models by interaction with melatonin receptors 1A (MT1) 1B (MT2). MT1 MT2 can form heterodimers homodimers, but heterodimerize the orphan receptor G protein–coupled 50 (GPR50). MT1/GPR50 dimerization blocks binding, MT2/GPR50 does not affect binding. GPR50 dimerize TGFβ type I (TGFβRI) to activate this receptor. We aimed determine differential roles of during cholestasis. Approach Results Wild‐type...
ABSTRACT Squamous cell carcinoma (SCC) has a high incidence in non‐human primates (NHPs), which affects animal health and causes huge losses to the experimental monkey breeding industry. In this case, gastroscope showed smooth‐surfaced elevated lesion located approximately 18 cm from incisor teeth of diseased rhesus monkey. Computed tomography (CT) space‐occupying oesophagus. Haematoxylin & eosin (HE) staining revealed an invasive tumour polygonal nests submucosa muscularis, while...
Blastocystis is a prevalent gut eukaryote intricately associated with the microbiota. This genetically diverse protozoan exhibits significant intra-host subtype heterogeneity, yet implications of this diversity for host microbiome remain poorly understood. Here, we investigated interactions between and microbiota in non-human primates at level subtypes, using comprehensive investigation carriers captive Macaca fascicularis (discovery cohort, n = 100) mulatta (validation 26). We identified...
Melatonin, a neuroendocrine hormone synthesized by the pineal gland and cholangiocytes, decreases biliary hyperplasia liver fibrosis during cholestasis-induced injury via melatonin-dependent autocrine signaling through increased arylalkylamine N-acetyltransferase (AANAT) expression melatonin secretion, downregulation of miR-200b specific circadian clock genes. Melatonin synthesis is decreased pinealectomy (PINX) or chronic exposure to light. We evaluated effect PINX prolonged light on...
Background & aims: Cholangiocytes are the target cells of liver diseases that characterized by biliary senescence (evidenced enhanced levels senescence-associated secretory phenotype, SASP, e.g., TGF-β1), and inflammation fibrosis accompanied altered bile acid (BA) homeostasis. Taurocholic (TC) stimulates hyperplasia activation 3′,5′-cyclic cyclic adenosine monophosphate (cAMP) signaling, thereby preventing damage (caused cholinergic/adrenergic denervation) through angiogenesis. Also:...
Proliferative diabetic retinopathy (PDR) involves persistent, uncontrolled formation of premature blood vessels with reduced number pericytes. Our previous work showed that advanced glycation endproducts (AGEs) induced angiogenesis in human umbilical vein endothelial cells, mouse retina and aortic ring, which was associated moesin phosphorylation. Here we investigated whether phosphorylation may contribute to pericyte detachment the development PDR. Primary retinal microvascular pericytes...
Background and Aims: Secretin (SCT) secretin receptor (SR, only expressed on cholangiocytes within the liver) play key roles in modulating liver phenotypes. Forkhead box A2 (FoxA2) is required for normal bile duct homeostasis by preventing excess of cholangiocyte proliferation. Short-term administration SR antagonist (SCT 5–27) decreased ductular reaction fibrosis ligated Mdr2 −/− [primary sclerosing cholangitis (PSC), model] mice. We aimed to evaluate effectiveness risks long-term SCT 5–27...
Primary sclerosing cholangitis (PSC) is characterized by increased ductular reaction (DR), liver fibrosis, hepatic total bile acid (TBA) levels, and mast cell (MC) infiltration. Apical sodium BA transporter (ASBT) expression increases in cholestasis, ileal inhibition reduces PSC phenotypes. FVB/NJ multidrug-resistant 2 knockout (
Primary sclerosing cholangitis (PSC) is characterized by biliary senescence and hepatic fibrosis. Melatonin exerts its effects interacting with receptor 1 2 (MT1/MT2) melatonin receptors. Short-term (1 wk) treatment reduces a ductular reaction liver fibrosis in bile duct-ligated rats down-regulation of MT1 clock genes, multidrug resistance gene knockout (Mdr2-/-) mice decreased miR200b-dependent angiogenesis. We aimed to evaluate the long-term on phenotype that may be mediated changes...
Alcohol-related liver disease (ALD) is characterized by ductular reaction (DR), inflammation, steatosis, fibrosis, and cirrhosis. The secretin (Sct)/secretin receptor (SR) axis (expressed only cholangiocytes) regulates phenotypes in cholestasis. We evaluated the role of Sct signaling on ALD phenotypes. used male wild-type Sct-/- mice fed a control diet (CD) or ethanol (EtOH) for 8 wk. Changes were measured mice, female/male healthy controls, patients with alcoholic Since Cyp4a10 Cyp4a11/22...