A5029095538- Hemodynamic Monitoring and Therapy
- Ultrasound in Clinical Applications
- Sepsis Diagnosis and Treatment
- Cardiac Arrest and Resuscitation
- Venous Thromboembolism Diagnosis and Management
- Heart Rate Variability and Autonomic Control
- Respiratory Support and Mechanisms
- Intensive Care Unit Cognitive Disorders
- Heart Failure Treatment and Management
- Cardiac, Anesthesia and Surgical Outcomes
- Cardiac electrophysiology and arrhythmias
- Anesthesia and Pain Management
- Atrial Fibrillation Management and Outcomes
- Renal function and acid-base balance
- COVID-19 Clinical Research Studies
- Mechanical Circulatory Support Devices
- Cardiac and Coronary Surgery Techniques
- Pulmonary Hypertension Research and Treatments
- Sulfur Compounds in Biology
- Vagus Nerve Stimulation Research
- Cardiovascular and exercise physiology
- Nausea and vomiting management
- Cardiovascular Function and Risk Factors
- EEG and Brain-Computer Interfaces
- Anesthesia and Neurotoxicity Research
Ljubljana University Medical Centre
2012-2025
College of Nursing in Celje
2005-2025
University of Ljubljana
2016-2025
Splošna Bolnišnica Celje
2001-2024
Community Health Centre Ljubljana
2006-2014
BIA (Slovenia)
2013
Columbia University
2013
University Medical Center
2009
Türkiye Yüksek İhtisas Hastanesi
2003
Importance Red blood cell (RBC) transfusion is common among patients admitted to the intensive care unit (ICU). Despite multiple randomized clinical trials of hemoglobin (Hb) thresholds for transfusion, little known about how these are incorporated into current practice. Objective To evaluate and describe ICU RBC practices worldwide. Design, Setting, Participants International, prospective, cohort study that involved 3643 adult from 233 ICUs in 30 countries on 6 continents March 2019 October...
Abstract Introduction Our aim was to determine long-term survival and quality of life patients admitted a surgical intensive care unit (ICU) because sepsis or trauma. Methods This an observational study conducted in 11-bed, closed ICU at 860-bed teaching general hospital over 1-year period (January 2003 December 2003). Patients were divided into two groups according admission diagnoses: group 1 included with sepsis; 2 trauma (polytrauma, multiple trauma, head injury, spinal injury). Quality...
This study aimed to establish the incidence, number and location of CPR-related skeletal chest injuries (SCI) investigate influence age, gender, changes in resuscitation guidelines technique resuscitation.We analysed SCI 2148 patients who had undergone for non-traumatic cardiac arrest, as shown by autopsies performed at Institute Forensic Medicine Ljubljana period 2004-2013.External massage caused 86% males 91% females; sternum fractures occurred 59% 79% females, rib 77% 85% females...
In a healthy individual, ammonia is converted to urea in the liver. Urea then transported through bloodstream and excreted into urine by kidneys. patients with chronic kidney disease (CKD), accumulated degraded salivary urease ammonia, which breathing. Breath can therefore be used for detecting increased nitrogen-bearing wastes. our pilot study, an electrochemical sensor was measure analyze breath volunteers CKD.In 8 CKD (stages 4 5) 6 were enrolled. All participants nonsmokers without...
Abstract Introduction Low cardiac output states such as left heart failure are characterized by preserved oxygen extraction ratio, which is in contrast to severe sepsis. Near infrared spectroscopy (NIRS) allows noninvasive estimation of skeletal muscle tissue oxygenation (StO 2 ). The aim the study was determine relationship between StO and mixed venous saturation (SvO ) patients with or without additional sepsis septic shock. Methods Sixty-five due primary disease were divided into two...
Extracorporeal hemadsorption may reduce inflammatory reaction in cardiopulmonary bypass (CPB) surgery. Glucocorticoids have been used during open-heart surgery for alleviation of systemic inflammation after CPB. We compared intraoperative and methylprednisolone, with usual care, complex cardiac on CPB, responses, hemodynamics, perioperative course. Seventy-six patients prolonged CPB were recruited randomized, 60 included final analysis. Allocation was into three groups: Methylprednisolone (n...
Myoblast proliferation and myotube formation are critical early events in skeletal muscle regeneration. The attending inflammation cytokine signaling involved regulation of cell differentiation. Secretion muscle‐derived cytokines upon exposure to inflammatory factors may depend on the differentiation stage regenerating cells. Cultured human myoblasts myotubes were exposed 24‐hour treatment with tumor necrosis factor (TNF)‐ α or lipopolysaccharide (LPS). interleukin 6 (IL‐6), a major...
Rhabdomyolysis is a pathophysiological process characterized by the destruction of muscle cells and release intracellular contents into systemic circulation, which can lead to acute kidney injury (AKI) failure. Causes are classified mainly as traumatic non-traumatic, with statin-induced rhabdomyolysis being widely recognized. Other causes seldomly reported, one red yeast rice (RYR) or its active ingredient, monacolin K. We present life-threatening case fulminant severe hyperkalemia,...
Abstract Introduction Discrepancies of 5-24% between superior vena cava oxygen saturation (ScvO 2 ) and mixed venous (SvO have been reported in patients with severe heart failure. Thenar muscle tissue oxygenation (StO measured near-infrared spectroscopy (NIRS) during arterial occlusion testing decreases slower sepsis/septic shock (lower StO deoxygenation rate). The rate is influenced by dobutamine. aim this study was to determine the relationship ScvO -SvO discrepancy left failure additional...
Inhibition of pyruvate dehydrogenase kinase (PDK) emerged as a potential strategy for treatment cancer and metabolic disorders. Dichloroacetate (DCA), prototypical PDK inhibitor, reduces the abundance some isoenzymes. However, underlying mechanisms are not fully characterized may differ across cell types. We determined that DCA reduced PDK1 in breast (MDA-MB-231) prostate (PC-3) cells, while it suppressed both PDK2 skeletal muscle cells (L6 myotubes). The DCA-induced suppression was...
Cytokine release syndrome (CRS) is immune dysregulation phenomenon that associated with checkpoint inhibitors. It still difficult to distinguish CRS from other dangerous, acute and life-threatening medical disorders.
Background: COVID-19 can cause acute pulmonary hypertension (PH), worsening outcomes in critically ill elderly patients. Point-of-care ultrasound (POCUS), assessing right ventricular hemodynamics, predicts short-term outcomes. This study examines the long-term impact of PH on mortality Methods: retrospective analyzed data from patients over 70 years old with severe pneumonia admitted to a mixed 25-bed, level 3 intensive care unit (ICU). POCUS focused systolic artery pressure (sPAP) at...