Diabetic kidney disease is a frequent microvascular complication of diabetes and currently the leading cause chronic end-stage worldwide. Although prevalence other complications falling, number diabetic patients with in need replacement therapy rising. In addition, these have extremely high cardiovascular risk. It more than evident that there unmet treatment disease. Finerenone novel nonsteroidal mineralocorticoid receptor antagonist used for treating has predominant anti-fibrotic...

In a healthy individual, ammonia is converted to urea in the liver. Urea then transported through bloodstream and excreted into urine by kidneys. patients with chronic kidney disease (CKD), accumulated degraded salivary urease ammonia, which breathing. Breath can therefore be used for detecting increased nitrogen-bearing wastes. our pilot study, an electrochemical sensor was measure analyze breath volunteers CKD.In 8 CKD (stages 4 5) 6 were enrolled. All participants nonsmokers without...

This retrospective study aimed to evaluate the 30 and 60-day survival of critically ill patients with COVID-19 AKI.

<title>Abstract</title> <bold>Background</bold> Hyperlactatemia is common in intensive care unit (ICU) patients. The aim of our retrospective observational study was to analyse the impact serum lactate on admission mortality patients with acute kidney injury (AKI) treated renal replacement therapy (RRT). <bold>Methods</bold> During period 4 years, 2939 were admitted ICU, 503 diagnosed AKI and 209 them required RRT. After excluding chronic dialysis known malignant disease, we retrospectively...

Vitamin D is a crucial fat-soluble compound primarily involved in maintaining calcium-phosphate balance and promoting bone health. In recent years, its broader physiological roles, particularly cardiovascular (CV) kidney function, have garnered significant interest. Deficiency vitamin widespread issue, affecting large portion of the global population, associated with various health problems, including CV disease. Research suggests adequate levels help preserve vascular reduce inflammation...

Chronic kidney disease and heart failure (HF) are closely related conditions that often coexist complicate each other. Both can exacerbate progression influence treatment strategies. Angiotensin receptor- neprilysin inhibitors (ARNIs) playing an increasingly important role in the of HF. ARNIs combine two mechanisms action: sacubitril is a inhibitor enhances natriuretic peptides, resulting vasodilation, diuresis reduced cardiac workload; valsartan angiotensin II receptor blocker reduces...

Abstract Introduction Functional changes in peripheral arterial disease (PAD) could play a role higher cardiovascular risk these patients. Methods 123 patients who underwent elective coronary angiography were included. Ankle-brachial index (ABI) was measured and stiffness parameters derived with applanation tonometry. Results 6 (4.9%) had previously known PAD (Rutherford grade I). Mean ABI 1.04 ± 0.12, mean subendocardial viability ratio (SEVR) 166.6 32.7% carotid-femoral pulse wave velocity...

Obesity is associated with several neurohumoral changes that play an essential role in organ damage. Increased arterial stiffness causes functional vessel wall and can therefore lead to accelerated target damage as well. Whether obesity independent increase central is, however, not yet fully known.One hundred thirty-three patients (63.2% male) were included. Body Mass Index (BMI) was defined body weight kilograms, divided by the square of height meters. Chronic Kidney Disease Epidemiology...

Dehydration in older adults is an important clinical problem associated with more comorbidities, longer hospital stays, and higher mortality rates. However, daily practice, no single gold standard marker of hydration status available. The aim the current study was to define fluid balance residing institutional care or home. Four hundred ten patients (192 from 218 home care) 65 region lower Styria (Slovenia) were included study. Serum osmolality, electrolytes, blood urea nitrogen creatinine...

Chronic kidney disease (CKD) is a risk factor for cardiovascular and all-cause mortality. Recognition of high-risk patients important could lead to different approach better treatment. The CHA2DS2-VASc score was originally used predict cerebral infarction in with atrial fibrillation (AF), but it also useful predictor outcome other conditions, independent AF. Therefore, the aim our research assess role predicting mortality CKD patients.Stable nondialysis were included. At time inclusion,...

Atherosclerosis is a chronic, inflammatory vascular disease, characterized by progressive plaque build-up in the vessel wall, leading to tissue ischemia. It most common cause of cardiovascular diseases and major epidemiologic concern modern society. The pathophysiology atherosclerosis includes two main events: endothelial injury wall inflammation. Recent findings indicate that pathogenesis involves dynamic changes epigenetic modifications gene expression cell type- stage-specific manner....

A 72-year-old female patient presented with an end-stage renal disease on on-line hemodiafiltration and warfarin therapy advanced ulcerated calciphylaxis the lower extremities, complicated by two episodes of cellulitis. She was successfully treated for 8 months intravenous sodium thiosulfate in combination modification medication dialysis treatment, careful wound care, other supportive measures. Calciphylaxis is uncommon life-threatening systemic disease, mostly occurring patients chronic...

Statins or 3-hydroxy-3-methylglutaryl coenzyme A reductase inhibitors are a mainstay of cardiovascular disease therapy. In addition to their lipid-lowering capabilities, they exhibit several pleiotropic effects. Their adverse reactions such as myalgias not uncommon, but in rare cases, the resulting rhabdomyolysis can be fatal. Recently, more insight has been brought into pathogenesis statin-induced rhabdomyolysis, and immune-mediated necrotizing myopathies diagnosed frequently. We present...

The atherosclerotic state of haemodialysis (HD) patients may be influenced by heavy metals. purpose our study was to assess the relationship between serum zinc (Zn) ankle brachial index (ABI) as a non-invasive diagnostic tool for atherosclerosis, and mortality in chronic patients.Sixty one HD were included (mean age 61.2 ± 13.8 years). ABI measured with an automated measuring device (ABPI MD, MESI®, Slovenia). Two groups formed based on median value Zn (14.1 mcmol/l). average observation...

Lung ultrasound (LUS) is a non-invasive technique for estimating extravascular lung water in patients with end-stage renal disease and heart diseases. In this study, we examined an association between the severity of congestion as detected by LUS B-lines (LUS comets), anemia, serum biomarker N-terminal pro-brain natriuretic peptide (NT-proBNP) peritoneal dialysis (PD) patients.19 patients, who were treated PD our center enrolled. On day their routine check-up, performed auscultation, on 28...

Background Sarcoidosis is characterized by granulomatous inflammation in multiple organs. Renal involvement rare, and tubulointerstitial nephritis (TIN) the predominant histologic feature. TIN also a hallmark of uveitis (TINU) syndrome. Diagnoses both sarcoidosis TINU syndrome are usually made exclusion combining clinical histological findings, often remain misdiagnosed. The aim this retrospective study was to determine characteristics renal Slovenia last decade (2010 - 2020). Materials...