A5043949516- Receptor Mechanisms and Signaling
- Anesthesia and Pain Management
- Cardiac, Anesthesia and Surgical Outcomes
- Anesthesia and Sedative Agents
- Eicosanoids and Hypertension Pharmacology
- Erythropoietin and Anemia Treatment
- Iron Metabolism and Disorders
- Blood transfusion and management
- Anesthesia and Neurotoxicity Research
- Cancer, Stress, Anesthesia, and Immune Response
- Sphingolipid Metabolism and Signaling
- Airway Management and Intubation Techniques
- Hemoglobinopathies and Related Disorders
- Ion channel regulation and function
- Nausea and vomiting management
- Blood donation and transfusion practices
- Trauma Management and Diagnosis
- Neuroscience and Neuropharmacology Research
- Antiplatelet Therapy and Cardiovascular Diseases
- Respiratory Support and Mechanisms
- Inflammatory mediators and NSAID effects
- Neuropeptides and Animal Physiology
- Intraocular Surgery and Lenses
- Cerebral Venous Sinus Thrombosis
- High Altitude and Hypoxia
University Hospital Münster
2001-2025
University of Vechta
2012-2025
University of Münster
1999-2022
Medizinische Hochschule Hannover
2013-2021
German Red Cross
2021
Krankenhaus vom Roten Kreuz
2021
University Hospital of Bern
2021
University of Bern
2021
Marienhospital Stuttgart
2004-2019
Helios Universitätsklinikum Wuppertal
2015
Climate change is a global threat, and inhalational anesthetics contribute to warming by altering the photophysical properties of atmosphere. On perspective, there fundamental need reduce perioperative morbidity mortality provide safe anesthesia. Thus, will remain significant source emissions in foreseeable future. It is, therefore, necessary develop implement strategies minimize consumption ecological footprint We have integrated recent findings concerning climate change, characteristics...
During the inhalation of anaesthesia use low fresh gas flow (0.35-1 L/min) has some important advantages. There are three areas benefit: pulmonary - with improves dynamics inhaled gas, increases mucociliary clearance, maintains body temperature and reduces water loss. Economic reduction consumption resulting in significant savings > 75% Ecological nitrous oxide consumption, which is an ozone-depleting heat-trapping greenhouse that emitted. Nevertheless, high flows 2-6 L/min still performed,...
The oculocardiac reflex (OCR) is induced by mechanical stimulation and therefore frequently encountered during strabismus surgery. This study was designed to determine how various anaesthetic regimes modulate the haemodynamic effects of OCR paediatric Thirty‐nine patients (4–14 years, ASA I) were randomized one four regimes: group P: propofol (12 mg·kg –1 ·h ) alfentanil (0.04 ); S: sevoflurane 1–1.2 MAC in 30% O 2 /70% N O; K: ketamine racemate (10–12 midazolam (0.3–0.6 ; H: halothane O....
During general anesthesia, physiologic conditioning of inspired gases is bypassed. Mechanical ventilation with dry and cold gas from the central supply may lead to dehydration mucus membranes, cilia dysfunction, retention secretions, atelectasis. The use metabolic fresh flow improves inspiratory but increases water vapour condensation within breathing system. We sought investigate effects circuit insulation on vapour. In this in vitro study, we used a mechanical nonheated, nonhumidified lung...
Despite an intriguing cell biology and the suggestion of a role in pathophysiological responses, mechanism action such lipid phosphoric acid mediators as lysophosphatidic (LPA) remains obscure, part because underdeveloped medicinal chemistry. We report now agonist activity synthetic phospholipid which glycerol backbone LPA is replaced by l-serine. Like LPA, l-serine-based mobilizes calcium inhibits activation adenylyl cyclase human breast cancer line MDA MB231. Treatment with desensitizes...
Background: Iron deficiency anemia (IDA) is common in critically ill patients treated the intensive care unit (ICU), and it can lead to severe consequences. Precise immediate diagnostics are not available, but they inevitably needed administer adequate therapy. Serological parameters such as serum ferritin transferrin saturation (TSAT) heavily influenced by simultaneous inflammation reactions, resulting need for more suitable parameters. Reticulocyte biomarkers reticulocyte hemoglobin...
Some local anesthetics (LA), in concentrations present blood during IV or epidural infusion, inhibit thrombus formation the postoperative period. Studies on thromboxane A2 (TXA2) signaling a recombinant model suggest that interference with TXA2-induced platelet aggregation may explain, part, antithrombotic actions of analgesia and LA infusion. In this study we investigated effects clinically used LAs (lidocaine, ropivacaine, bupivacaine) early (1–5 s) by using quenched-flow optical...
Prostaglandin E2 receptors, subtype EP1 (PGE2EP1) have been linked to several physiologic responses, such as fever, inflammation, and mechanical hyperalgesia. Local anesthetics modulate these which may be due direct interaction of local with PGE2EP1 receptor signaling. We sought characterize the anesthetic effects on signaling elucidate mechanisms action. In Xenopus laevis oocytes, recombinant expressed receptors were functional (half maximal effect concentration, 2.09 ± 0.98 × 10−6 M)....
Thromboxane A2 (TXA2) is a member of the prostaglandin family; activation its receptor induces several important effects, including platelet aggregation and smooth muscle contraction. Because volatile anesthetics interfere with contraction, authors investigated effects halothane, isoflurane, sevoflurane on TXA2 signaling in an isolated model.mRNA encoding receptors was prepared vitro expressed Xenopus oocytes. The Ca2+-activated Cl- currents induced by agonist U-46619 those intracellular...
We investigated the mechanism of benzocaine (permanently uncharged) and QX314 charged) inhibition lysophosphatidic acid (LPA) signaling. To determine their site action, we studied effects these drugs, alone in combination, on LPA-induced Ca2+-dependent Cl currents (I(Cl(Ca))) Xenopus oocytes. After 10 min exposure to benzocaine, (10(-6)-10(-2) M), or both, measured I(Cl(Ca)) induced by LPA (with without protein kinase [PKC] activation/inhibition) intracellular injection IP3 GTPgammaS....
Background and objective Minimal- low-flow anaesthesia (fresh gas flow below 1 L min−1) provide many advantages, including reduced cost, conservation of body heat airway humidity. An airtight seal is essential between the device patient. Therefore, we investigated whether created by a laryngeal mask allows controlled ventilation lungs when fresh to 0.5 min−1 compared this with an endotracheal tube.Methods In prospective clinical study, 207 patients were managed using or tube. After...
In Brief ThromboxaneA2 (TXA2)has been proposed as a mediator of perioperative myocardial ischemia, vasoconstriction, and thrombosis. As these adverse events are minimized with epidural anesthesia, rather than general we hypothesized that local anesthetics would inhibit TXA2-receptor signaling. We used fluorometric determination intracellular [Ca2+] in human K562 cells 2-electrode voltage clamp measurements Xenopus laevis oocytes expressing TXA2 receptors. After 10-min incubation, lidocaine...
Sudden visual loss after general anesthesia is a rare and serious complication. Unilateral can be caused by an increase in pressure the preretinal veins with subsequent rupture hematoma formation. Our patient most likely experienced venous as consequence of temporarily increased intrapulmonary pressures during sustained Valsalva maneuver shortly tracheal intubation. Although surgical correction available, almost all cases, no specific therapy required because problem completely regresses...
We investigated the mechanism of benzocaine (permanently uncharged) and QX314 charged) inhibition lysophosphatidic acid (LPA) signaling.To determine their site action, we studied effects these drugs, alone in combination, on LPA-induced Ca2 +-dependent Cl currents (ICl(Ca)) Xenopus oocytes. After 10 min exposure to benzocaine, (10-6-10-2 M), or both, measured ICl(Ca) induced by LPA (with without protein kinase [PKC] activation/inhibition) intracellular injection IP3 GTP gamma S. application...
Lumbar laminectomy is a common and usually routine operation, but it can occasionally result in sudden, life-threatening complications. Such events require rapid therapy, so essential that anesthesiologists be aware of these potential complications, as well their manifestations treatment. We report the occurrence aortic perforation, an uncommon potentially fatal complication lumbar laminectomy. Case Report A 42-yr-old, healthy woman (56 kg, 160 cm) was admitted for L5-S1 Her medical history...