A5023374930- Cytokine Signaling Pathways and Interactions
- MicroRNA in disease regulation
- Cancer-related molecular mechanisms research
- FOXO transcription factor regulation
- Animal testing and alternatives
- Human-Animal Interaction Studies
- Liver Disease Diagnosis and Treatment
- Liver Disease and Transplantation
- 3D Printing in Biomedical Research
- Cancer Cells and Metastasis
- Autophagy in Disease and Therapy
- Circular RNAs in diseases
- Liver physiology and pathology
- Animal and Plant Science Education
- Angiogenesis and VEGF in Cancer
- Bone fractures and treatments
- Kruppel-like factors research
- Cancer-related Molecular Pathways
- Biochemical effects in animals
- Tuberculosis Research and Epidemiology
- Medieval Iberian Studies
- Comparative Literary Analysis and Criticism
- Breast Cancer Treatment Studies
- Veterinary Practice and Education Studies
- Spaceflight effects on biology
Universitat de Barcelona
2012-2022
Hospital Universitari Germans Trias i Pujol
2019
Consorci Institut D'Investigacions Biomediques August Pi I Sunyer
2014-2018
Centro de Investigación Biomédica en Red
2015-2018
Institut d'Investigació Biomédica de Bellvitge
2012-2017
Hospital Clínic de Barcelona
2015
Centro de Investigación Biomédica en Red de Enfermedades Hepáticas y Digestivas
2014
Indiana University – Purdue University Indianapolis
2014
Boston Scientific (Netherlands)
2014
Guerbet (United States)
2014
Abstract Paracrine signaling through receptor activator of NF-κB (RANK) pathway mediates the expansion mammary epithelia that occurs during pregnancy, and activation RANK promotes tumorigenesis in mice. In this study we extend these previous data to human cells show development stem breast cancer. Overexpression (FL-RANK) a panel tumoral normal induces expression cancer basal/stem cell markers. High levels untransformed MCF10A induce changes associated with both stemness transformation,...
Abstract The socioeconomic and medical improvements of the last decades have led to a relevant increase in median age worldwide population. Although numerous studies described impact aging different organs systemic vasculature, relatively little is known about liver function hepatic microcirculatory status elderly. In this study, we aimed at characterizing phenotype aged rat model healthy aging, particularly focusing on molecular each cell type sinusoid. Moreover, major findings study were...
Highlights•PDX models mimic the clinical response to docetaxel in breast cancer patients•Sensitivity can be regained metastatic resistant TNBC•A tumor-initiating CD49f chemoresistant population is present TNBC•Docetaxel resistance associates with expansion of a CD49f+ TNBCSummaryTaxanes are mainstay treatment for cancer, but often develops followed by disease and mortality. Aiming reveal mechanisms underlying taxane resistance, we used patient-derived orthoxenografts (PDX). Mimicking...
Hepatic stellate cells (HSC) play a key role in the development of chronic liver disease (CLD). Liraglutide, well-established type 2 diabetes, showed anti-inflammatory and anti-oxidant properties. We evaluated effects liraglutide on HSC phenotype hepatic microvascular function using diverse pre-clinical models CLD. Human rat were vitro treated with liraglutide, or vehicle, their phenotype, viability proliferation evaluated. In addition, vehicle was administered to rats Liver function,...
The immunological characterization of different cell markers has opened the possibility considering them as immune tools for tuberculosis (TB) management, they could correlate with TB latency/disease status and outcome. CD4+ T-cells producing IFN-+ a low expression CD27 have been described an active marker. In addition, there are unknown homing receptors related to TB, such CCR4, which might be useful understanding pathogenesis. aim our study is focused on assessment several T-cell subsets...
We describe a unique, versatile bioreactor consisting of two plates and modified commercial porous membrane suitable for in vitro analysis the liver sinusoid. The modular allows i) excellent control cell seeding process; ii) culture under controlled shear stress stimulus, and; iii) individual each type upon completion experiment. advantages detailed here are derived from modification with an elastomeric wall specifically moulded order to define area, act as gasket that will fit into...
Many workers contribute to the success of animal welfare and study outcomes in biomedical research. However, professional quality life (ProQoL) those who work with laboratory animals has not been explored Spain. To this end, we adapted ProQoL scale Spanish population working animals. Participants were contacted by email asked complete an anonymous on-line questionnaire. The comprised a total 498 participants, 12.4% officers/veterinarians, 19.5% caretaker/technicians, 13.9% principal...
Abstract Background The use of animals in biomedical science remains controversial. An individual’s level concern is generally influenced by their culture, previous or current experience with animals, and the specific animal species question. In this study we aimed to explore what people Spain who had never no longer worked laboratory thought mice, pigs, dogs monkeys for research purposes. We also determine whether not currently involved aforementioned felt work was justified. Results...
Abstract Background Replacement, reduction and refinement, the 3R principles, provide a framework to minimize use suffering of animals in science. In this context, we aimed determine actual perception that individuals working with laboratory rodents biomedical research have on animal welfare their interaction animals, as well how they perceive its impact social relations. To end, designed an anonymous on-line survey for people rodents, at three responsibility levels, Spain. Results Of 356...
Purpose: To evaluate retrospectively the safety, technical success and clinical efficacy of hepatic vein stenting in management clinically evident venous outflow obstruction complicating orthotopic liver transplantation.Material methods: From 2003 to 2013, 24 patients ( 8 female 16 male), including 23 adults one adolescent (17 years age) underwent stent placement for after transplant.Pre post deployment pressure gradients were measured.Results: Reduction gradient was achieved .Reduction...
<p>PDF file - 72K, RANK overexpression induces mammary stem markers</p>
<p>PDF file - 168K, RANK expression induces a CD44+CD24- phenotype in breast cancer cells with non functional BRCA1 and enhances the mesenchymal markers MDA-MB-436 cells.</p>
<p>PDF file - 113K, RANK expression induces EMT in MCF10A and HMECS immortalized with telomerase</p>
<p>PDF file - 89K, RANK/RANKL expression significantly associates with tumor subtype and lymph node metastasis</p>
<p>PDF file - 114K, FL-RANK cells grow in the absence of EGF and do not form tumors vivo.</p>
<p>PDF file - 167K</p>
<p>PDF file - 172K, RANK overexpression promotes growth, invasive changes and metastasis in cells with non-functional BRCA1</p>
<p>PDF file - 91K, RANK is expressed and active in MCF10A cells</p>
<p>PDF file - 91K, RANK is expressed and active in MCF10A cells</p>
<p>PDF file - 172K, RANK overexpression promotes growth, invasive changes and metastasis in cells with non-functional BRCA1</p>
<p>PDF file - 89K, RANK/RANKL expression significantly associates with tumor subtype and lymph node metastasis</p>
<p>PDF file - 167K</p>