Abstract The global rise in overweight and obesity has been exacerbated by sedentary lifestyles suboptimal dietary habits. Traditional weight loss methods often struggle with adherence due to restrictive diets metabolic adaptations. Intermittent meal replacement (IMR), incorporating formulated protein-enriched nutritional shakes, emerged as a potential strategy for management. However, its combined effects moderate-intensity continuous training (MICT) remain underexplored. This study aimed...

Alcoholic liver damage is caused by long-term or heavy drinking, and it may further progress into alcoholic diseases (ALD). Probiotic supplements have been suggested for the prevention improvement of damage. This study was designed to consider ameliorative effects Lactobacillus rhamnosus NKU FL1-8 isolated from infant feces against The mice were gavaged with a 50% ethanol solution treated 109 CFU L. suspension. factors function, oxidative stress, inflammation, gut microbiota composition,...

Food allergy (FA) has become a prominent problem in public health.

It has been widely accepted that resistant starch (RS) provides numerous health benefits for human<strong>. </strong>In this research, we aimed at evaluating the performance of novel starch-lipid complexes, RS5, in comparison with RS2 on physical features, glucolipids metabolism, inflammation, and gut microbiota profiles Type 2 diabetes mellitus (T2DM) rats. The T2DM model was established by streptozotocin injection to high-fat-sugar fed According a serial biochemical analyses, found RS5...

The widespread dissemination of carbapenem-resistant Klebsiella pneumoniae (CRKP) and its drug resistance transfer poses a global public health threat. While previous studies outlined CRKP’s mechanism, there is limited research on strategies inhibiting CRKP spread. This study investigates the potential Bifidobacterium longum (B. longum) FB1-1, probiotic, in curbing spread among by evaluating cell-free supernatant (CFS) for antibacterial activity. Evaluating inhibitory effect FB1-1 CFS...

Foxtail millet has been traditionally considered to possess gastroprotective effects, but studies evaluating its use as a treatment for gastric ulcers are lacking. Here, we assessed the antiulcer effects of foxtail protein hydrolysate (FPH) and explored mechanism by using blocking agents. In mouse model ethanol-induced ulcers, pretreatment with FPH reduced ulcerative lesion index, downregulated expression inflammatory cytokines in tissue, increased activity antioxidant enzymes, improved...

// Jianyong Qi 1, 2, * , Wenjun Pan Yafang Tan Jiaru Luo Dancai Fan 2 Juan Yu 3 Jiashin Wu 4 and Minzhou Zhang 1 AMI Key Laboratory of Chinese Medicine in Guangzhou, The Second Affiliated Hospital Guangzhou University Medicine, Guangdong Province 510006, China Intensive Care Research Team Traditional Animal Center, Department Pharmaceutical Sciences, College Pharmacy, Northeast Ohio Medical University, Rootstown, 44272, USA These authors have contributed equally to this work share the first...

The Chinese formula Pien Tze Huang (PZH) has been used to treat hepatocellular carcinoma (HCC) and showed positive clinical effects. However, the antitumor mechanism of PZH in HCC remains unclear. In this study, xenograft Balb/c mice were treated with PZH; then, proteomics detection Ingenuity Pathway Analysis (IPA) analyze differentiated phosphorylated proteins tumor tissues. results indicated that could inhibit weight by 50.76%. Eighty-four upregulated 11 downregulated identified...

Abstract Objectives Constipation is a prevalent gastrointestinal issue, and the efficacy of probiotics in alleviating constipation has been well proved. This study aimed to investigate impact Bifidobacterium longum subsp. infantis NKU FB3-14 on loperamide- induced by focusing improving intestinal barrier function modulating gut microbiota composition Materials Methods The constipated model mice loperamide were treated with FB3-14, laxative effect was assessed based fecal water content, first...

The liver is essential for metabolic and immune functions has been linked to systemic inflammatory diseases. However, the role of still elusive during development rheumatoid arthritis (RA), although there have indeed some reports. We used label-free quantitative proteomics experimental verification in this study reveal hepatic lipid metabolism function collagen-induced (CIA) development. results revealed that differs different phases CIA rats. In terms specific performance, metabolism, which...

Wang-Bi Capsule (WB), a traditional Chinese medicine- (TCM-) based herbal formula, is currently used in clinic for the treatment of rheumatoid arthritis (RA) with positive clinical effects. However, its pharmacological mechanism action RA still obscure. Therefore, this study established collagen-induced (CIA) mice model to examine efficacy WB by using score, histological analysis, and micro-CT examination. Proinflammatory cytokines expression, osteoclast number, OPG/RANKL system, NF-κB...

Single nutrient likes polyphenol or dietary fiber have been exhaustively investigated to validate their positive intervention in health disease. Meanwhile, the common interaction of inner systems with complex has not well elucidated, which raises scientific issue modulatory effect on immunity. The representative prebiotics epigallocatechin-3-gallate (EGCG), ginseng extract, and polydextrose (PDX) were selected behalf classification polyphenol, flavone polysaccharides, generally cover daily...

poses a significant threat, particularly to neonates and infants. Despite its strong pathogenicity, understanding of

ABSTRACT Psoriasis is a chronic autoimmune disease with long course and frequent relapse characteristics. It now recognised to be associated epidermal environments of inflammatory cytokines. However, its pathogenesis still not completely clear. We found the haemorheology psoriatic patients abnormal, ageing deformed erythrocytes increased in blood. The abnormal were more likely induce psoriasis, which was confirmed mouse model induced by different blood components patients/healthy volunteers....

Background: 5-Fluorouracil (5-FU) is a common chemotherapeutic medication used to treat cancer. However, the intestinal tract may sustain oxidative damage as result. Objectives: The purpose of this study was clarify underlying molecular mechanisms and examine preventive benefits cereal-based fermented drinks (CFBs) against injury in mice caused by 5-FU. Methods: were injected intraperitoneally with 5-FU induce mucosal treated CFB. factors for barrier integrity, stress inflammation measured....

Abstract Background Psoriasis is a chronic autoimmune disease with long course and frequent relapse characteristics, however, its pathogenesis still not completely clear. Clinical study indicated that blood state abnormal in psoriasis seems related the severity of psoriasis. However, whether this true which constituents play key role mechanism behind Methods Effect on development was determined by comparing serum, red cells, leukocytes onset NOG mice, using samples healthy people as control....