A5010904801- Liver Disease Diagnosis and Treatment
- Liver Disease and Transplantation
- Regulation of Appetite and Obesity
- Adipose Tissue and Metabolism
- Biochemical Analysis and Sensing Techniques
- Metabolism and Genetic Disorders
- Eicosanoids and Hypertension Pharmacology
- Adipokines, Inflammation, and Metabolic Diseases
- Barrier Structure and Function Studies
- Clinical Nutrition and Gastroenterology
- Renal function and acid-base balance
- Diet and metabolism studies
- Nitric Oxide and Endothelin Effects
- Helicobacter pylori-related gastroenterology studies
- Gut microbiota and health
- Heart Rate Variability and Autonomic Control
- Biochemical effects in animals
- Nutrition and Health in Aging
- Diet, Metabolism, and Disease
- COVID-19 Clinical Research Studies
- Cardiovascular, Neuropeptides, and Oxidative Stress Research
- Ferroptosis and cancer prognosis
- Diabetes, Cardiovascular Risks, and Lipoproteins
- Drug-Induced Hepatotoxicity and Protection
- Cancer-related molecular mechanisms research
Jawaharlal Institute of Post Graduate Medical Education and Research
2016-2025
University of Florence
2024
ITPEnergised Group (India)
2023
Creative Research Enterprises (United States)
2017
University College London
2007-2017
Annamalai University
2003-2016
Hospital Clínic de Barcelona
2015
Consorci Institut D'Investigacions Biomediques August Pi I Sunyer
2015
Martin Luther University Halle-Wittenberg
2015
The Royal Free Hospital
2011-2015
Abstract Objective In liver failure, inflammation synergistically exacerbates the deleterious cerebral effects of ammonia. The aims were to test whether treatment with ammonia‐lowering agent ornithine phenylacetate ( OP ) and/or anti‐ TNF ‐α (infliximab) prevent brain consequences lipopolysaccharide LPS in cirrhotic rats. Design Rats 4 weeks following bile duct‐ligation BDL ), sham‐operation (sham) 7 days hyperammonemic feed HD randomized receive (1 mg/kg) or saline, and either 3...
Ammonia is central in the pathogenesis of hepatic encephalopathy, which associated with dysfunction nitric oxide (NO) signaling pathway. Ornithine phenylacetate (OP) reduces hyperammonemia and brain water cirrhotic animals. This study aimed to determine whether endothelial NO synthase activity altered animals, this changes endogenous inhibitor, asymmetric-dimethylarginine (ADMA) its regulating enzyme, dimethylarginine-dimethylaminohydrolase (DDAH-1), these abnormalities are restored by...
Hepatocellular carcinoma (HCC) is a frequent type of primary liver cancer, and its prevalence increasing worldwide. Indeed, the underlying molecular mechanism not well understood. Previous studies have shown evidence that tight junction (TJ) components were correlated with carcinogenesis tumor development. Our aims to determine serum levels protein Zonula Occludens (ZO)-1 an inflammatory marker such as high-sensitive C-reactive (hs-CRP) in HCC patients compared healthy volunteers also...
Insulin resistance (IR) is a collective clinical entity that exacerbates metabolic syndrome (MetS). As the gold-standard test to quantify IR involves intravenous insulin loading and repeated blood glucose monitoring, many indices have been developed for assessment convenience. This study tested ideal cut-off values utility of in identifying MetS.We recruited 150 subjects, 75 MetS patients healthy controls, then obtained written informed consent participate this study. We collected fasting...
Cirrhosis, a leading cause of global mortality, necessitates an accurate assessment disease severity and prognosis. While traditional scoring systems like Child-Turcotte-Pugh (CTP) model for end-stage liver (MELD) are used to assess the severity, specific biomarkers lacking. This study explores serum prolactin levels as potential biomarker evaluating cirrhosis predicting short-term mortality. A prospective observational was conducted from December 2021 2023. After thorough clinical...
Aim: Our previous study provided evidence that systemic zonula occludens (ZO) 1 levels are elevated in cirrhotic and hepatocellular carcinoma (HCC) patients. Here, we aimed to evaluate serum ZO-1 patients with decompensated alcoholic cirrhosis (DCAC) hepatorenal syndrome (HRS) compare its diagnostic potential the well-established HRS biomarker, cystatin C. Methods: A total of 36 DCAC 40 healthy volunteers were recruited. Serum ZO-1, C, clinical chemistry parameters analysed. Results:...
Background: The choice of fluid is important in neurosurgical patients, who may be dehydrated due to the administration diuretics order reduce cerebral edema. Normal saline, infused routinely used can cause hyperchloremic metabolic acidosis. A balanced crystalloid (BC) help maintain status more favorably these without adversely affecting brain relaxation.Methods: We conducted a prospective, randomized controlled trial on patients undergoing elective craniotomy for supratentorial tumor...
Abstract Excess body fat (BF) contributes to metabolic syndrome (MetS). The Clínica Universidad de Navarra—Body Adiposity Estimator (CUN‐BAE) is an equation‐derived estimator proposed assess BF. However, its efficiency compared the standard method unknown. We aimed compare efficacy of CUN‐BAE with in estimating BF southern Indians. included 351 subjects, 166 MetS patients and 185 non‐MetS subjects. was obtained from bioelectrical impedance analysis (BIA) measured by same that BIA via...
BACKGROUND Altered tight junction (TJ) proteins are correlated with carcinogenesis and tumor development. Nimbolide is a tetranotriterpenoid that has been shown to have antioxidant anti-proliferative properties; however, its anticancer effects molecular mechanism in hepatocellular carcinoma (HCC) remains obscure. AIM To investigate the effect of nimbolide on TJ proteins, cell cycle progression, hepatic inflammation mouse model HCC. METHODS HCC was induced male Swiss albino mice (CD-1 strain)...
Gut microbiota imbalance plays a key pathological role in hepatocellular carcinoma (HCC) progression; however, the mechanism is poorly understood. We previously showed nimbolide impede tumor development by improving hepatic tight junction (TJ) proteins expression and attenuating inflammation HCC mice. Here, we aimed to study of regulating gut bacterial translocation (BT) through modulating intestinal TJ an experimental hepatocarcinogenesis. Nimbolide (6 mg/kg) was administered orally for 4...