A5067075838- Liver Disease Diagnosis and Treatment
- Liver Disease and Transplantation
- COVID-19 Clinical Research Studies
- Long-Term Effects of COVID-19
- Intensive Care Unit Cognitive Disorders
- Metabolism, Diabetes, and Cancer
- Diabetes Treatment and Management
- Cardiovascular Function and Risk Factors
- Heart Rate Variability and Autonomic Control
- Innovations in Medical Education
- Sepsis Diagnosis and Treatment
- Simulation-Based Education in Healthcare
- Medical Education and Admissions
- Adrenal Hormones and Disorders
- Bone and Joint Diseases
- Influenza Virus Research Studies
- Vector-borne infectious diseases
- Diabetes, Cardiovascular Risks, and Lipoproteins
- Academic Writing and Publishing
- Fungal Plant Pathogen Control
- Cardiac electrophysiology and arrhythmias
- Pneumonia and Respiratory Infections
- Cardiovascular Disease and Adiposity
- scientometrics and bibliometrics research
- Renin-Angiotensin System Studies
Jawaharlal Institute of Post Graduate Medical Education and Research
2015-2025
All India Institute of Medical Sciences
2023
Christian Medical College
2023
Christian Medical College, Vellore
2023
The appropriate antibiotic treatment for severe scrub typhus, a neglected but widespread reemerging zoonotic infection, is unclear.
Objectives: Severe scrub typhus, a rickettsial disease with multi-organ failure, is highly fatal infectious disease. IV doxycycline, azithromycin, or their combination are commonly used in the treatment, but comparative efficacy needs to be better established. This study aims describe PK of these two drugs and PD as monotherapy and, combination, using GPDI, which could help optimize drug regimens. Methods: 744 patients over 15 years old severe typhus were recruited. Plasma concentrations...
Aim: Our previous study provided evidence that systemic zonula occludens (ZO) 1 levels are elevated in cirrhotic and hepatocellular carcinoma (HCC) patients. Here, we aimed to evaluate serum ZO-1 patients with decompensated alcoholic cirrhosis (DCAC) hepatorenal syndrome (HRS) compare its diagnostic potential the well-established HRS biomarker, cystatin C. Methods: A total of 36 DCAC 40 healthy volunteers were recruited. Serum ZO-1, C, clinical chemistry parameters analysed. Results:...
Brucella melitensis, a gram-negative coccobacillus, is the causative agent of zoonotic disease brucellosis. Brucellosis can present with variety signs and symptoms hence diagnosis becomes difficult. To ensure that patient receives appropriate treatment, laboratory testing necessary to confirm diagnosis. The advent automated systems has made identification brucellosis easier. This facilitates early initiation antibiotics, thereby improving clinical outcome.
Coronavirus disease 2019 (COVID-19) predominantly involves the lungs, albeit many other organ systems, including hypothalamic-pituitary-adrenal (HPA) axis, can be affected due to expression of angiotensin-converting enzyme 2 (ACE2) binding receptor. Few studies have reported involvement adrenal gland and HPA axis during acute phase COVID-19; however, data on long-term effect COVID-19 after infection is scarce.To assess compare changes in mild, moderate severe categories at ≥ 3 months...
Background This work aimed to evaluate the influence of single nucleotide polymorphisms (SNPs) in SLC47A1 (922-158G>A; rs2289669) and SLC47A2 (-130G>A; rs12943590) genes on relative change HbA1c type 2 diabetes mellitus (T2DM) patients South India who are taking metformin as monotherapy. It also aims study effects these SNPs dose requirement for glycemic control adverse metformin. Methods Diabetes monotherapy were recruited based eligibility criteria (n=105). DNA was extracted genotyping...
hospital, Puducherry, India, after obtaining the approval from Institute Research Council and Human Ethics Committee.A written informed consent was taken study subjects, prior to recruitment.Fortyone T2DM patients
Genetic polymorphisms of the angiotensin-renin pathway have been thought to influence development diabetic nephropathy. However, there are conflicting results regarding this association in previous studies on populations with varying ethnicity.Primary aim was compare frequency distribution angiotensin-converting enzyme (ACE) gene (insertion/deletion [I/D]) polymorphism Tamilian Indian type 2 individuals and without microalbuminuria. Secondary objective 3 genotypes patients urinary...
Renal failure occurring in the setting of cirrhosis increases mortality by more than threefold. Serum creatinine, conventional marker for renal dysfunction has inherent limitations identifying and categorizing patients with chronic liver disease (CLD). Neutrophil gelatinase associated lipocalin (NGAL) is a novel biomarker which gets upregulated as early 2-6 hours following insult to tubules. In this study, we aim check utility uNGAL identify different phenotypes CLD. We also intend assess...
Background On December 21, 2019, a pneumonia-like outbreak of an unknown cause or origin was found to be emerging in Wuhan, China. In India, the first case COVID-19 Kerala and then started spread all over India. Most infected people have recovered from disease, but some patients were symptoms at post-discharge follow-up. Although there are many studies on signs during hospital stays, is scarcity information regarding post-COVID-19 manifestations. The purpose this study analyze clinical...
While medical students are expected to learn procedural skills during their training, there is no consensus on level of learning. Further, the most essential across curricula which need be taught III-year clinical posting often not considered. The purpose this study was identify core needed undergraduate posting.
Severe acute respiratory syndrome coronavirus 2 disease (COVID-19) has caused more than 6 million deaths globally. Understanding predictors of mortality will help in prioritizing patient care and preventive approaches. This was a multicentric, unmatched, hospital-based case-control study conducted nine teaching hospitals India. Cases were microbiologically confirmed COVID-19 patients who died the hospital during period controls discharged from same after recovery. recruited sequentially...
Referral of sepsis patients at the level primary care is often delayed due to lack an assessment tool which effectively predicts sepsis. The quick Sepsis-related Organ Failure Assessment score (qSOFA) can be used in such scenarios improve patient outcomes.To assess prognostic accuracy qSOFA predicting adverse outcomes with suspected infections and compare it SIRS (Systemic Inflammatory Response Syndrome) SOFA (Sequential failure Score).This study included 180 participants admitted emergency...
Spontaneous bacterial peritonitis (SBP) is an acute infection of ascitic fluid without obvious source. The prevalence SBP in patients with cirrhosis the range 10%-30%. With increasing use antibiotics, there a gradual shift causative flora from Gram-negative bacteria to Gram-positive and, more importantly, drug-resistant bacteria. aim this retrospective study on 721 cases was identify various organisms causing along their drug sensitivity and resistance patterns. A 38.2% culture positivity...
BACKGROUND: The growing recognition of the importance simulation-based training has been a present focus medical education curriculum planners. This study aims to design, develop, implement, and evaluate educational outcomes modules for list essential skills that MBBS students in tertiary care teaching hospital South India need learn as part their competency-based curriculum. MATERIALS AND METHODS: sequential transformative mixed method will be implemented three phases: i) identification...
We report a case of 41-year-old lady, who developed severe hypotension and sinus bradycardia, following oral consumption 20 g phenytoin 500 mg glibenclamide. She required high dose inotropes temporary transvenous pacer for her hemodynamic instability. This life-threatening cardiotoxicity could have been due to its interaction with sulphonylurea. It is imperative be aware drug interactions, which, cardiovascular manifestations toxicity can occur.
Introduction: Drug transporters are key determinants of pharmacokinetic and pharmacodynamic profiles certain drugs. SLC47A1 (MATE1) SLC47A2 (MATE2) major efflux involved in the hepatic renal excretion many cationic drugs including metformin. Our study was proposed to determine normative frequencies single nucleotide polymorphisms (SNPs) rs2289669 rs12943590 genes, respectively, South Indian population also compare those with HapMap populations. Methods: One hundred two unrelated healthy...
Dapagliflozin, an SGLT2 inhibitor used in the management of Type 2 diabetes mellitus, has been recently approved for control worsening cardiovascular events, including deaths and hospitalizations, adults with heart failure reduced ejection fraction. Previously, canagliflozin had a label change regards to its additional usage reduction risk hospitalization patients both mellitus diabetic nephropathy albuminuria. On other hand, therapeutic application empagliflozin ertugliflozin is yet be...
Liver cirrhosis is associated with cardiac dysfunction in 40%-60% of the patients. Serum NT-ProBNP a potential additional marker cirrhotic cardiomyopathy.It was cross-sectional analytical study done tertiary care center South India on 100 patients liver. Diastolic function assessed from mitral inflow parameters as well tissue Doppler imaging left ventricle 95 levels measured once at time inclusion into study. Cirrhotic cardiomyopathy diagnosed those abnormal echocardiographic and its...
We aimed to study the factors including model for end stage liver disease (MELD) score in predicting mortality women with pregnancy-specific diseases (P-sLD). A total of 154 clinical jaundice were studied which 138 diagnosed P-sLD. The most common P-sLD was HELLP syndrome (51.9%) followed by acute fatty pregnancy (AFLP) (17.5%). mean age 26.3 ± 4.7 years and gestational 35.1 4.2 weeks. maternal death rate 26.8% cause coagulopathy sepsis. MELD among non survivors 25.98 8.17 compared 17.29...
Listeria monocytogenes, a gram-negative bacillus, can contaminate food, leading to listeriosis, foodborne illness that poses serious threat public health. It is known cause invasive diseases, such as bacteremia, meningitis, and encephalitis, in neonates, elderly immunocompromised patients. Thus, there needs be greater awareness about listeriosis. Early diagnosis appropriate antibiotic treatment are important the survival of monocytogenes bacteremia. Here we present case bacteremia caused by...
Abstract Peer review is the evaluation of scientific, academic, or professional work by experts in field. This process starts when editor a peer-reviewed journal sends an article manuscript to two more reviewers for review. They convey their suggestions editor. If reviews are positive, requests authors revise and resubmit manuscript. The corresponding author provides point-wise explanation various queries raised resubmits paper. may send paper re-review, following which makes final decision....
Leptospirosis is a serious public health concern worldwide. It highly endemic in the Andaman Islands and its prevalence increasing other Indian states. Clinical features are non-specific diagnosis relies on laboratory confirmation. The gold standard microscopic agglutination testing, but this not widely available. Real-time polymerase chain reaction testing of LipL32 antigen provides earliest detection pathogenic Leptospira body. We found it to be 100% specific, should used first 10 days...
Sepsis diagnosis and management is aided by the use of newer biomarkers like procalcitonin presepsin. For prognostication, presepsin may be better than procalcitonin.Ninety-two participants, suspected to suffering from sepsis varied etiologies were included in this study at time their presentation emergency health services. Presepsin estimated patient followed up till discharge or death. Receiver operating curve (ROC) curves, sensitivity, specificity, positive negative likelihood ratios...