After fourteen decades of medical and technological evolution, infective endocarditis continues to challenge physicians in its daily diagnosis management. Its increasing incidence, demographic shifts (affecting older patients), microbiology with higher rates Staphylococcus infection, still frequent serious complications substantial mortality make a very complex disease. Despite this, innovations the diagnosis, involving imaging, improvements intensive care cardiac surgical techniques,...

Abstract Introduction Cardiac resynchronization therapy (CRT) is recommended in patients with heart failure (HF), but 1/3 of are "non-responders". More recent algorithms promote electrical optimization by dynamically adjusting atrioventricular intervals, reducing QRS duration. However, their impact on left ventricular function parameters remains unclear. Objectives The following echocardiographic were evaluated and compared pre-CRT at 12 months follow-up: (LV) diastolic systolic volume;...

Journal Article Accepted manuscript A severe case of Q Fever Endocarditis Get access João Cravo, Cravo Department Cardiology, Centro Hospitalar Universitário Lisboa Norte, CAML@CCULRISE, Faculdade de Medicina Universidade Lisboa, Portugal Corresponding author Email:[email protected] https://orcid.org/0009-0004-6758-0772 Search for other works by this on: Oxford Academic PubMed Google Scholar Jéssica Vasconcelos, Vasconcelos Internal Medicine Department, Diana Palácios, Palácios Catarina...

Caffeine (1,3,7-trimethylxanthine) is a natural product commonly presented in food's composition, beverages and medicinal products. Generally, it thought to be safe under normal dosage, yet can fatal case of severe intoxication. We report healthy 32-year-old woman who went the local emergency department (ED) 30 min after ingesting, accidentally, 5000 mg anhydrous caffeine for preworkout supplement. At ED, she an episode presyncope followed by agitation. ECG showed polymorphic broad complex...

Abstract Background Nationwide hospital admissions data series have contributed to a reliable assessment of the changing epidemiology infective endocarditis, even though conclusions are not uniform. We sought use recent populational describe temporal trends on incidence its clinical characteristics and outcome results, in Portugal. Methods A nationwide retrospective trend study characterization patients hospitalized with between 2010 2018. Results 7574 were endocarditis from 2018 Portuguese...

Neurological abnormalities are common in patients with organic acidaemias and sometimes these distinctive. Lesions various parts of the brain increasingly being recognised methylmalonic acidaemia. We present cases two acidaemia who became acutely ill marked metabolic acidosis. CT scan showed bilateral areas low density involving globi pallidi. One patient developed dystonic posturing upper lower limbs rigidity bradykinesia following her recovery. Treatment benzhexol levodopa carbidopa had no...

The spectrum of hypertensive heart disease is wide, and can include left ventricular dysfunction. development echocardiographic parameters to improve patient stratification identify early adverse changes could be clinically useful. To subclinical dysfunction in subjects with preserved ejection fraction (>55%), identified by global myocardial strain on speckle tracking imaging. This was a comparative observational study two groups individuals: normotensive (n=20, age 59±7 years, 55% male)...

Early identification of patients with infective endocarditis (IE) at higher risk for in-hospital mortality is essential to guide management and improve prognosis.

Journal Article Carnitine and Weakness in Haemodialysis Patients Get access M. E. Rogerson, Rogerson 1Department of Nephrology, King's College Hospital School Medicine, The Dulwich HospitalLondon Correspondence offprint requests to: Dr Clinical Lecturer St Philips Hospital, Sheffield Street, London WC2A 2EX. Tel. 01-242 9831 Search for other works by this author on: Oxford Academic PubMed Google Scholar P. B. Rylance, Rylance R. Wilson, Wilson C. De Sousa, Sousa 2Section Perinatal Child...

O espectro da cardiopatia hipertensiva é diverso podendo ir até à disfunção ventricular esquerda. desenvolvimento de metodologias ecocardiográficas que permitam melhorar o estadiamento e identificar precocemente hipertensos em risco evolução desfavorável poderá ser clinicamente relevante. Identificar compromisso subclínico função esquerda indivíduos com fração ejeção preservada (> 55%), utilizando parâmetros globais deformação miocárdica (speckle tracking). Foram estudados dois grupos...

16S rRNA gene sequencing is widely used to characterize human and environmental microbiomes. Sequencing at scale facilitates better powered studies but limited by cost time. We identified two areas in our library preparation protocol where modifications could provide efficiency gains, including (1) pooling of multiple PCR amplifications per sample reduce drift (2) manual mastermix liquid handling. Using nasal samples from healthy participants a serially diluted mock microbial community, we...

1. Plasma and urine free total carnitine acylcarnitine levels were assayed in 12 control subjects 20 chronic alcoholics with fatty liver. Although the had a wider range of values than controls, there was no significant difference between two groups. 2. Hepatic long- short-chain acylcarnitines by radioenzymatic method samples from seven alcoholics. No differences any indices noted patient groups it concluded that deficiency did not contribute to alcoholic liver patients without cirrhosis. 3....

Conference Article| August 01 1986 Acylcarnitines in urine medium-chain acyl-CoA dehydrogenase deficiency measured by quantitative high-pressure liquid chromatography B. M. TRACEY; TRACEY 1Perinatal and Child Health, M.R.C. Clinical Research Centre, Watford Road, Harrow HA1 3UJ, U.K. Search for other works this author on: This Site PubMed Google Scholar R. A. CHALMERS; CHALMERS J. ROSANKIEWICZ; ROSANKIEWICZ C. DE SOUSA; SOUSA T. E. STACEY Biochem Soc Trans (1986) 14 (4): 700–701....

Brain natriuretic peptide (BNP) is a highly sensitive and specific biomarker for the extent of myocardial infarction that strongly related to short- long-term prognosis in patients with acute coronary syndromes.To assess prognostic value BNP levels Portuguese cohort ST-elevation (STEMI) patients.We performed retrospective analysis admitted STEMI included Registry Acute Coronary Syndromes (ProACS) between 2010 2019. Patients were divided into three groups according level (<100 pg/ml, 100-399...