A5040066452- Synthetic Organic Chemistry Methods
- Chemical Synthesis and Reactions
- Sulfur-Based Synthesis Techniques
- Multicomponent Synthesis of Heterocycles
- Synthesis and Catalytic Reactions
- Catalytic C–H Functionalization Methods
- Chemical Synthesis and Analysis
- Click Chemistry and Applications
- Supramolecular Self-Assembly in Materials
- Carbohydrate Chemistry and Synthesis
- Origins and Evolution of Life
- Microbial Natural Products and Biosynthesis
- Photosynthetic Processes and Mechanisms
- Synthesis and Characterization of Heterocyclic Compounds
- Chemical synthesis and alkaloids
- Synthesis of Indole Derivatives
- Asymmetric Synthesis and Catalysis
- Synthesis and Reactivity of Heterocycles
- Marine Sponges and Natural Products
- RNA Interference and Gene Delivery
- Asymmetric Hydrogenation and Catalysis
- Synthesis and biological activity
- Catalytic Cross-Coupling Reactions
- Photoreceptor and optogenetics research
- Protein Kinase Regulation and GTPase Signaling
Scripps Research Institute
2016-2021
Weatherford College
2021
Icahn School of Medicine at Mount Sinai
2020
Old Dominion University
2014-2015
Jawaharlal Nehru Technological University, Hyderabad
2014-2015
Indian Institute of Chemical Technology
1997-2014
University of Pittsburgh
1970
The development of metabolic approaches towards understanding the origins life, which have focused mainly on citric acid (TCA) cycle, languished-primarily due to a lack experimentally demonstrable and sustainable cycle(s) reactions. We show here existence protometabolic analog TCA involving two linked cycles, convert glyoxylate into CO2 produce aspartic in presence ammonia. reactions proceed from either pyruvate, oxaloacetate or malonate as carbon source hydrogen peroxide oxidant under...
The direct sulfenylation of indoles with aromatic thiols has been accomplished in the presence 20 mol% FeCl3 refluxing acetonitrile to produce 3-arylthioindoles relatively good excellent yields and high selectivity. This method works even 2-unsubstituted indoles.
A novel method has been devised for anti-1,3-aminoalcohols through reductive elimination of iodomethyltetrahydropyrans which are in turn derived from a Prins/Ritter reaction sequence. The synthetic versatility this explored the total synthesis piperidine alkaloids and β-amino acids.
Abstract SelectfluorTM is found to catalyze efficiently the electrophilic thiocyanation of indoles and pyrrole with ammonium thiocyanate under mild neutral conditions produce corresponding 3-indolyl 2-pyrrolyl thiocyanates, respectively, in excellent yields high selectivity. This method effective even azaindole carbazole while many reported procedures failed thiocyanates from azaindole.
Eighteen new glycolipids were synthesized and characterized. All eighteen are effective molecular gelators for at least one solvent eleven hydrogelators concentrations of 0.15–1.0 wt%. The hydrogels suitable carriers sustained release chloramphenicol.
Abstract A highly stereoselective total synthesis of attenols and B is described. The salient features this are the utilization a reductive radical cyclization strategy for methyl center creation, Prins cyclization/reductive opening cascade anti ‐1,3‐diol motif generation, double alkylation tosylmethyl isocyanide (TosMIC) to construct spiro acetal segment.
Abstract A stereoselective total synthesis of the 2-(2-hydroxyalkyl)piperidine alkaloids has been accomplished by a Prins–Ritter amidation sequence. Other steps involved in this are Jacobsen's hydrolytic kinetic resolution (HRK) and ring-closing metathesis (RCM).
Abstract Nitrile/cyanide hydrolysis is of importance from the perspective organic chemistry, especially, prebiotic chemistry. Herein we report that cyanohydrins, generated by reaction cyanide with β‐keto acids and γ‐keto‐alcohols, spontaneously hydrolyze under ambient conditions (aqueous medium, RT, a range pH). The spontaneous affected an intramolecular proton transfer 5‐ exo ‐dig attack, but twist. In case acids, mediated neighboring carboxylic acid group only at pH values less than 7,...
A highly efficient and environmentally benign protocol has been developed for the first time to produce a wide range of biologically active 5-hydroxyindole derivatives using montmorillonite KSF clay as reusable solid acid catalyst. The use recyclable makes this procedure quite simple, more convenient cost-effective.
The nucleophilicity of the α-carbon malonate, coupled with its potential for subsequent decarboxylation, makes it an intriguing building block in prebiotic chemical scenarios. In this work, a variety citric acid cycle (TCA) intermediates is shown to unexpectedly generate malonate oxidizing environment. reactions are facile aqueous solution containing hydrogen peroxide, prevalent abiotic oxidant. modern metabolism, carbon source acetyl-CoA. Additionally, thioester substrate biosynthesis both...
Eco-friendly, one-pot three-component syntheses of 2-(3H-imidazo[4,5-b]pyridine-2-yl)-N-arylbenzamides have been developed by combining phthalic anhydride with anilines and pyridine-2,3-diamine in water without any catalyst. These reactions involves easy workup, provide good yields use as solvent which were the merits this preparation. Keywords: 3-diamine, anilines, anhydride, pyridine-2, water.
One-pot, four component syntheses for the preparation of 1-H Pyrazolo[1,2-b]phthalazine-5,10-diones (5a-5h) and 2H-indazolo[2,1-b]phthalazine-1,6,11(13-H)-triones (7a-7f) have been described from phthaloyl dichloride (1) , hydrazine hydrate (2), benzaldehydes (3) malononitrile (4a), ethyl cynoacetate (4b) or dimedone (6) in refluxing water 1-1.5 h by in-situ generation HCl as a catalyst. These reactions an easy workup, provide excellent yields, use solvent. Keywords: Water, dichloride,...