Abstract: Eucalyptol, also known as 1,8-cineole, is a monoterpene traditionally used to treat respiratory disorders due its secretolytic properties. In addition myorelaxant effects, it has anti-inflammatory actions in vitro. this study, we aimed evaluate the efficacy of acute treatment with 1,8-cineole on reducing airway inflammatory parameters. Ovalbumin (OVA)-sensitized guinea pigs were submitted antigenic challenge (OVA) or without pre-treatment single dose administered by inhalation....

1-Nitro-2-phenylethane is the first organic NO2-containing molecule isolated from plants. It possesses interesting hypotensive, bradycardic, and vasodilator properties, but mode by which it induces vasorelaxation still unknown. The underlying mechanism involved in effect of 1-nitro-2-phenylethane was investigated rat aorta. vasorelaxant effects did not depend on endothelial layer integrity, were refractory to L-NG-nitroarginine methyl ester (L-NAME)-induced nitric oxide synthase inhibition....

Ischemia/reperfusion (I/R) injury and metabolic acidosis (MA) are two critical conditions that may simultaneously occur in clinical practice. The result of this combination can be harmful to the kidneys, but issue has not been thoroughly investigated. present study evaluated influence low systemic pH on various parameters kidney function rats were subjected an experimental model renal I/R injury. Metabolic was induced male Wistar by ingesting ammonium chloride (NH4Cl) tap water, beginning 2...

Summary 1,8‐Cineole is a terpenoid constituent of essential oils with anti‐inflammatory properties. It reduces the neural excitability, functions as an antinociceptive agent and has myorelaxant actions in guinea‐pig airways. The aim present study was to investigate mechanism underlying effects 1,8‐cineole isolated trachea from either naïve guinea‐pigs or ovalbumin (OVA)‐sensitized animals subjected antigenic challenge. Isometric recordings were made tone tracheal rings. Rings intact...

The present study deals with the pharmacological effects of sesquiterpene alcohol (-)-α-bisabolol on various smooth-muscle preparations from rats. Under resting tonus, (30-300 µmol/L) relaxed duodenal strips, whereas it showed biphasic in other preparations, contracting endothelium-intact aortic rings and urinary bladder relaxing these tissues at higher concentrations (600-1000 µmol/L). In precontracted either electromechanically (by 60 mmol/L K(+)) or pharmacomechanically phenylephrine...

Introdução: Plantas medicinais e fitoterápicos são tradicionalmente utilizados na cicatrização de diversos tipos feridas. Muitas plantas contêm compostos bioativos com propriedades anti-inflamatórias, antimicrobianas cicatrizantes. Objetivo: Reunir evidências clínicas do uso feridas cutâneas. Metodologia: Trata-se uma revisão integrativa da literatura. Os estudos foram coletados das bases dados MEDLINE/PubMed LILACS, utilizando como estratégia busca os termos ((Wound Healing) ou...

The effects of the essential oil Eucalyptus tereticornis (EOET), especially its constituents α- and β-pinene, were studied on rat trachea in vitro. In tracheal rings, EOET, or β-pinene potentiated contractions induced by acetylcholine (ACh). Contractions K+ (60 mM) also but reduced EOET. Our findings show that EOET has myorelaxant airways, potentiates ACh-induced contractions. Monoterpenes are involved potentiating actions, not responsible for effects. A putative inhibition...

Justicia pectoralis is a plant useful for the treatment of respiratory diseases. Here, we studied antiasthmatic properties standardized extract J. (Jp).Ovalbumin (OVA)-sensitized rats were actively challenged with saline or OVA to study airway hyper-responsiveness after oral Jp. The ability Jp inhibit hyper-reactivity was evaluated in isolated trachea mounted organ bath chamber.Using KCl carbachol as contractile agents, tracheal rings OVA-challenged contracted higher magnitude than saline....

In the present study, a practical activity is proposed to adopt an experimental approach demonstrate relationship between equilibrium potential for K(+) and transmembrane electrical without glass micropipettes. A conventional setup recording contractile of isolated smooth muscle preparations was used based on events elegantly described by Somlyo in 1960s. They showed that, response given stimulus, cells may contract, recruiting electromechanical or pharmacomechanical coupling mechanisms that...

Apis mellifera stings are a problem for public health worldwide, particularly in Latin America due to the aggressiveness of its Africanized honeybees. Massive poisoning by A. venom (AmV) affects mainly cardiovascular system, and several works have described actions on heart muscle. Nevertheless, no work pharmacological action mechanisms AmV isolated aorta has been reported. Thus, present aimed investigate main fractions, phospholipase A2 (PLA2) melittin, rings probable mechanism. complex...

Apesar do uso de plantas medicinais para tratamento problemas saúde ser tradicionalmente aceito, esta prática da medicina popular ainda encontra resistência por profissionais saúde, sobretudo sob a alegação falta comprovação seus efeitos. Durante o surto Covid-19, houve aumento significativo estresse, sintomas ansiosos e insônia fitoterápicos surge como uma alternativa terapêutica. O objetivo deste estudo foi realizar revisão literatura sobre eficácia terapia e/ou complementar transtornos...

Inhibition of type-5 phosphodiesterase by sildenafil decreases capacitative Ca2+ entry mediated transient receptor potential proteins (TRPs) in the pulmonary artery. These families channels, especially canonical TRP (TRPC) subfamily, may be involved development bronchial hyperresponsiveness, a hallmark asthma. In present study, we evaluated i) effects on tracheal rings rats subjected to antigen challenge, ii) whether extent TRPC gene expression modified and iii) inhibition (PDE5) alter after...

Inhibition of type-5 phosphodiesterase by sildenafil decreases capacitative Ca2+ entry mediated transient receptor potential proteins (TRPs) in the pulmonary artery. These families channels, especially canonical TRP (TRPC) subfamily, may be involved development bronchial hyperresponsiveness, a hallmark asthma. In present study, we evaluated i) effects on tracheal rings rats subjected to antigen challenge, ii) whether extent TRPC gene expression modified and iii) inhibition (PDE5) alter after...

Summary The aim of the present study was to investigate vascular effects E ‐isomer methyl cinnamate (E‐ MC ) in rat isolated aortic rings and putative mechanisms underlying these effects. At 1–3000 μ mol/L, E‐ concentration‐dependently relaxed endothelium‐intact preparations that had been precontracted with phenylephrine ( PHE ; 1 mol/L), an IC 50 value (geometric mean) 877.6 mol/L (95% confidence interval CI 784.1–982.2 mol/L). These vasorelaxant remained unchanged after removal endothelium...

Introdução: As Práticas Integrativas e Complementares em Saúde (PICS) integram práticas saberes milenares aos conhecimentos biomédicos ocidentais atuais. Dentro do SUS, especificamente na Atenção Primária à (APS), o principal local de atuação das PICS é nas Unidades Básicas (UBS). Objetivo: Avaliar uso no âmbito da APS município Mossoró/RN conhecimento dos gerentes UBS sobre as PICS. Metodologia: Realizou-se um estudo descritivo transversal com abordagem quantitativa qualitativa Mossoró....

2-Nitro-1-phenyl-1-propanol (NPP) is a nitro alcohol with vasodilator activity in the rat aorta. The present study investigated properties of NPP small vessels mesenteric bed, which, contrary to aorta, contains resistance vessels. Using myography, isometric contractions were recorded rings second- and third-order branches from artery. relaxed ring preparations that contracted phenylephrine, U-46619, KCl (40mM), resulting significantly different EC50 values (0.41μM [0.31-0.55μM], 0.16μM...

β-Phenylethylamine (β-PEA) is a trace amine with chemical proximity to biogenic amines and amphetamines. It an endogenous agonist of amine-associated receptors (TAARs) that acts as neuromodulator classic neurotransmitters in the central nervous system. At high concentrations, β-PEA contracts smooth muscle, role for TAARs these responses has been postulated. The dietary intake associated such symptoms hypertension migraine, especially after foods containing compounds. In gastrointestinal...

This study describes an undergraduate student laboratory activity using isolated preparations from rat gastrointestinal tissues that possess contractile profiles typically exhibited by striated and smooth muscle cells. While students are introduced to ex vivo methodology, they can compare differences in trace experiments, twitch aspects, phasic tonic properties, force-frequency relationships, pharmacological responsiveness of esophageal (striated) fundic (smooth muscle) segments. Muscle...

O objetivo deste trabalho foi analisar o uso de plantas medicinais por usuários da Atenção Primária à Saúde em Mossoró, RN, Brasil. Foi feito um levantamento através entrevistas com questionário semiestruturado a 100 participantes, dos quais 84% afirmaram utilizar medicinais, principalmente para afecções do sistema digestivo, respiratório e transtornos mentais comportamentais. Foram mencionadas 54 espécies vegetais, destacando-se boldo (Plectranthus barbatus Peumus boldus), hortelã (Mentha...

2-Nitro-1-phenyl-1-propanol (NPP) is a nitro alcohol that known as an intermediate in the synthesis of sympathomimetic agents, such norephedrine. The present study investigated vasoactive effects NPP on rat aorta. In endothelium-intact aortic rings, fully relaxed contractions were induced by phenylephrine, KCl, and U-46619. relaxant phenylephrine-elicited remained unaffected NG-nitro-l-arginine methyl ester (l-NAME), indomethacin, propranolol, tetraethylammonium, 4-aminopyridine,...