A5063277538- Venomous Animal Envenomation and Studies
- Healthcare and Venom Research
- Health, Nursing, Elderly Care
- Rabies epidemiology and control
- Ion channel regulation and function
- Health Education and Validation
- Insect and Pesticide Research
- Phytochemistry Medicinal Plant Applications
- Natural Antidiabetic Agents Studies
- Diabetes, Cardiovascular Risks, and Lipoproteins
- Diet, Metabolism, and Disease
- Marine Invertebrate Physiology and Ecology
- Child Nutrition and Water Access
- Advanced Glycation End Products research
- Antimicrobial Peptides and Activities
- Reproductive System and Pregnancy
- Inflammasome and immune disorders
- Phytochemicals and Antioxidant Activities
- Cytomegalovirus and herpesvirus research
- Blood Pressure and Hypertension Studies
- Cardiovascular and exercise physiology
- Drug-Induced Hepatotoxicity and Protection
- Healthcare Regulation
- Adipokines, Inflammation, and Metabolic Diseases
- Hormonal and reproductive studies
Universidade Federal do Ceará
2015-2024
Universidade Federal do Rio de Janeiro
2024
Universidade do Estado do Rio de Janeiro
2023
Center for Effective Philanthropy
2021
Universidade Federal Fluminense
2012-2020
National Council for Scientific and Technological Development
2019
Centro Universitário Católica de Quixadá
2018
Universidade Federal do Pará
2015
Centro de Estudos em Psicologia da Saúde
2015
University of Coimbra
2010
Endothelial dysfunction (ED) is an early feature of cardiovascular risk and diabetes. Hyperglycemia hyperlipidemia are causative factors. Excessive endothelial mitochondrial superoxide (ROS) production with hyperglycemia a key mechanism. Inositol components insulin inositol glycan mediator, d -chiro-inositol (DCI) 3- O -methyl DCI (pinitol), decrease hyperlipidemia. We tested whether these, myoinositol dibutyryl (db-DCI), would prevent or reverse ED in diabetic rats rabbits. Oral inositols...
The antidiabetic activity of aqueous, ethanolic and hexanic extracts Bauhinia forficata was investigated in a model alloxan-induced diabetes rats. biochemical parameters studied were: plasma glucose, serum triglycerides, cholesterol, high density lipoprotein (HDL), low (LDL). Extracts were administered daily for 7 d at doses 200 400 mg/kg, p.o., 48 h after alloxan injection (60 i.v.). alloxan-diabetic rats showed significant reductions total cholesterol HDL-cholesterol treatment with the...
Ischemia/reperfusion (I/R) in kidney is commonly related to acute injury (AKI), essentially through oxidative stress. (-)-α-Bisabolol a sesquiterpene isolated from the essential oil of variety plants, including chamomile, which has important antioxidant activity.This study intends evaluate nephroprotective activity (-)-α-bisabolol (Bis) both vivo and vitro models I/R.Male Wistar rats were submitted right nephrectomy, followed by ischemia clamping renal artery left for 60min. 48h reperfusion....
The clinical manifestations of Bothrops atrox envenoming involve local and systemic changes, among which edema requires substantial attention due to its ability progress compartmental syndromes sometimes cause tissue loss amputations. However, the impact on poisoned body's system has not been explored. Thus, present study aimed explore pathological inflammatory events that are altered by intraplantar injection B. venom in a mouse model through hematologic, lipidic, shotgun proteomics...
Sea anemones contain a variety of biologically active substances. Bunodosoma caissarum is sea anemone from the Cnidaria phylum, found only in Brazilian coastal waters. The aim present work was to study biological effects PLA(2) isolated B. on perfused kidney, arteriolar mesenteric bed and insulin secretion. Specimens were collected São Vicente Channel southern coast State Paulo, Brazil. Reverse phase HPLC analysis crude extract detected three proteins (named BcPLA(2)1, BcPLA(2)2 BcPLA(2)3)...
Bredemeyera floribunda roots are popularly used to treat snakebites in the semiarid region of Northeast Brazil, and previous studies indicate anti-ophidian actions triterpenoid saponins found its roots. To assess B. root extract (BFRE) activity against effects Bothrops jararacussu venom (BjuV), antiphospholipasic, antiproteolytic, antihemorrhagic, antinecrotic, anti-edematogenic activities were investigated mice. Phytochemical analysis revealed presence saponins, flavonoids, sugars, with...
HIGHLIGHTS Creatinine had negative correlation with HDLc and Apolipoprotein A-I; Insulin resistance was associated lower A-I albuminuria; has better predictive potential of kidney disease than HDLc.
Mammalian natriuretic peptides (NPs) have been extensively investigated for use as therapeutic agents in the treatment of cardiovascular diseases. Here, we describe isolation, sequencing and tridimensional homology modeling first C-type peptide isolated from scorpion venom. In addition, its effects on renal function rats mRNA expression receptors kidneys are delineated. Fractionation Tityus serrulatus venom using chromatographic techniques yielded a with molecular mass 2190.64 Da, which...
Resumo O objetivo deste artigo é comparar a avaliação das usuárias que participaram do PMAQ-AB acerca da saúde infantil entre os estados macrorregião Nordeste Brasil. Estudo transversal, realizado com dados secundários, partir de entrevista 5.116 4.190 Equipes Saúde Família atuam nos nove nordeste. Quatorze perguntas acompanhamento criança 0 2 anos idade foram avaliadas. Foram calculados proporções e intervalos confiança 95% segundo Unidade Federação região Os indicadores maiores teste...
Abstract Alginates isolated from Sargassum vulgare , present a strong antitumor activity, associated with kidney reversible damage, as analysed by histopathology of treated animals. In the study, renal alteration mechanisms S. alginates were investigated using perfused rat and mesenteric blood vessel methods. The results showed that effects low viscosity (SVLV) alginate more potent than those high (SVHV) in kidney. SVLV caused considerable changes physiology, shown an increase parameters...
Abstract Background Harpalycin 2 (HP-2) is an isoflavone isolated from the leaves of Harpalyce brasiliana Benth., a snakeroot found in northeast region Brazil and used folk medicine to treat snakebite. Its are said be anti-inflammatory. Secretory phospholipases A important toxins snake venom structurally related those inflammatory conditions mammals, as arthritis atherosclerosis, for this reason can valuable tools searching new anti-phospholipase drugs. Methods HP-2 piratoxin-III (PrTX-III)...
Apis mellifera stings are a problem for public health worldwide, particularly in Latin America due to the aggressiveness of its Africanized honeybees. Massive poisoning by A. venom (AmV) affects mainly cardiovascular system, and several works have described actions on heart muscle. Nevertheless, no work pharmacological action mechanisms AmV isolated aorta has been reported. Thus, present aimed investigate main fractions, phospholipase A2 (PLA2) melittin, rings probable mechanism. complex...
The present study investigated the effects of exercise on cardiac nuclear factor (erythroid-derived 2) 2 (NRF2)/Kelch-like ECH-associated protein 1 (KEAP1) pathway in an experimental model chronic fructose consumption. Male C57BL/6 mice were assigned to Control, Fructose (20% drinking water), Exercise (treadmill at moderate intensity), and + groups (n = 10). After 12 wk, energy intake body weight similar. Maximum testing, resting expenditure, oxygen consumption, carbon dioxide production...
Bothrops erythromelas is responsible for a large number of snakebite incidents in Northeastern Brazil. Previously, we showed the effects whole B. venom an isolated kidney model. To continue study with venom, present work aims to this on MDCK tubular epithelial cells and assess gene expression involved injury, aiming at elucidating mechanisms renal toxicity. Cytotoxicity IC50 93 μg/mL predominant apoptotic involvement demonstrated by flow cytometry assays caspase-3 caspase-8. In conclusion,...
The present study investigated the effects of murici and tapereba on improving hepatic inflammatory biomarkers in high-fat-diet rats. Female Wistar rats were divided into five groups (n = 10/group): control (CON), high-fat diet (HF), drink + (Mu-HF), (Tap-HF), blend (MT-HF). Drinks offered daily for 60 days, following which body liver weights, hepatosomatic indexes, serum parameters, profile, antioxidant activity (DPPH ORAC) analyzed. cell death cells was evaluated using flow cytometry. It...
Abstract Objectives Sertraline is often prescribed to patients suffering with end stage renal disease, but its action on kidney has not been investigated. We aimed investigate the pharmacological of sertraline rat emphasis underlying mechanisms involved in vascular actions drug. Methods The effects were evaluated isolated perfused kidneys and ring preparations mesenteric or segmental artery. Key findings In kidneys, prevented phenylephrine perfusion pressure, glomerular filtration rate,...
Abstract Low birth weight (LBW) seems to be a determining factor for many cardiovascular diseases in adult life. The objectives of this study were investigate the occurrence metabolic syndrome (MetS) and endothelial dysfunction adolescents with LBW compare them subjects normal weights (NBW). This retrospective cohort evaluated 172 (86 each group) aged 10–20 years, who born reference maternity hospital. following criteria adopted: International Diabetes Federation parameters diagnosis MetS...