A5102943742- SARS-CoV-2 and COVID-19 Research
- Drilling and Well Engineering
- HIV/AIDS Research and Interventions
- Vaccine Coverage and Hesitancy
- Antibiotic Use and Resistance
- Viral gastroenteritis research and epidemiology
- COVID-19 Clinical Research Studies
- Respiratory viral infections research
- Bacterial Identification and Susceptibility Testing
- SARS-CoV-2 detection and testing
- Clostridium difficile and Clostridium perfringens research
- HIV, Drug Use, Sexual Risk
- Pneumonia and Respiratory Infections
- Malaria Research and Control
- LGBTQ Health, Identity, and Policy
- Infection Control and Ventilation
- Pesticide Residue Analysis and Safety
- COVID-19 epidemiological studies
- Oil and Gas Production Techniques
- Hepatitis B Virus Studies
- Mosquito-borne diseases and control
- Indigenous Health, Education, and Rights
- Infective Endocarditis Diagnosis and Management
- Smoking Behavior and Cessation
- Nosocomial Infections in ICU
Nine Circles Community Health Centre
2019-2025
Case Western Reserve University
2005-2025
Providence Health Care
2016-2025
St. Paul's Hospital
2018-2025
University of British Columbia
2016-2025
London Health Sciences Centre
2020-2023
Impact
2019-2023
University School
2021-2023
Center for Global Health
2023
Western University
2020-2023
After BNT162b2 messenger RNA vaccination, antibody levels to spike, receptor-binding domain, and virus neutralization were examined in 149 nursing home residents 110 healthcare worker controls. Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2)-naive residents' median post-second vaccine dose titers are one-quarter that of SARS-CoV-2-naive workers.
Nursing home (NH) residents have borne a disproportionate share of SARS-CoV-2 morbidity and mortality. Vaccines limited hospitalisation death from earlier variants in this vulnerable population. With the rise Omicron future variants, it is vital to sustain broaden vaccine-induced protection. We examined effect boosting with BNT162b2 mRNA vaccine on humoral immunity Omicron-specific neutralising activity among NH healthcare workers (HCWs). longitudinally enrolled 85 (median age 77) 48 HCWs...
Pharmacotherapies for tobacco cessation are efficacious and recommended during quit attempts. Racial/ethnic minorities in the United States less likely to use medication-based aids cessation, despite greater difficulty achieving long-term abstinence. The reasons this include, among others, provider- patient-level considerations. Primary care clinicians play an important role encouraging racial/ethnic minority users pharmacotherapy. To better understand pharmacotherapy use, we conducted a...
Article1 July 1960HOMOLOGOUS SERUM HEPATITIS IN YOUTHFUL HEROIN USERSROBERT A. LEVINE, M.D., MARY ANN PAYNE, M.D.ROBERT M.D.Search for more papers by this author, authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-53-1-164 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptThe high incidence of homologous serum hepatitis among youthful drug addicts has been reported other...
Antibody decline occurred from 2 weeks to 6 months post-BNT162b2 mRNA vaccination in nursing home (NH) residents and healthcare workers. Antispike, receptor-binding domain, neutralization levels dropped >81% irrespective of prior infection. Notably, 69% infection-naive NH had neutralizing antibodies at or below the assay's limit detection.
Latent cytomegalovirus (CMV) infection is immunomodulatory and could affect mRNA vaccine responsiveness. We sought to determine the association of CMV serostatus prior severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) with antibody (Ab) titers after primary booster BNT162b2 vaccinations in healthcare workers (HCWs) nursing home (NH) residents. Nursing residents (N = 143) HCWs 107) were vaccinated serological responses monitored by serum neutralization activity against Wuhan...
Background: The COVID-19 pandemic has greatly affected nursing home residents (NHRs), a vulnerable group with high rates of illness and death. While vaccination is essential for reducing infections severe outcomes in the short term, it important to understand how long antibody levels neutralizing activity last. This understanding will help us create effective public health strategies term. According current CDC guidelines, individuals over age 65 should receive booster dose six months after...
Abstract Background The Canadian province of Manitoba has reported a 52% increase in HIV diagnoses during the past 5 years. Females are disproportionately affected by and multiple intersecting health social challenges, including houselessness, injection drug use, sexually transmitted blood borne infections, mental conditions. Program service development often ignore people’s complex lived experiences. Our aim was to describe recommendations made people living with (PLHIV) inform...
To improve time to identification of pathogens and detection resistance genes, we evaluated the BioFire FilmArray Blood Culture Identification Panel (BCID) as compared to: (1) direct MALDI-TOF MS (DM) (2) standardized culture-based (ID) with antibiotic susceptibility testing (AST). BCID gave an accurate in 102/112 (91 %) cases (102/103 for on-panel organisms). DM 91/112 (81 cases, 13/91 (14 requiring repeat from residual pellet. The mean result was 2.4 2.9 h DM, respectively. Standardized ID...
Abstract Background The BNT162b2 SARS-CoV-2 mRNA vaccination has mitigated the burden of COVID-19 among residents long-term care facilities considerably, despite being excluded from vaccine trials. Data on reactogenicity (vaccine side effects) in this population are limited. Aims To assess nursing home (NH) residents. provide a plausible proxy for predicting response population. Methods We enrolled and sampled NH community-dwelling healthcare workers who received vaccine, to local or...
The SARS-CoV-2 pandemic impact on nursing home (NH) residents prompted their prioritization for early vaccination. To fill the data gap vaccine immunogenicity in NH residents, we examined antibody levels after BNT162b2 mRNA to spike, receptor binding domain (RBD) and virus neutralization 149 111 health care worker controls. SARS-CoV-2-naive mount responses with nearly 4-fold lower median titers half anti-spike level compared healthcare workers. By contrast, SARS-CoV-2-recovered vaccinated...
Abstract High COVID-19 mortality among nursing home (NH) residents led to their prioritization for SARS-CoV-2 vaccination; most NH received BNT162b2 mRNA vaccination under the Emergency Use Authorization due first market and its availability. With residents’ poor initial vaccine response, rise of breakthrough infections outbreaks, characterization durability immunity inform public health policy on need boosting is needed. We report humoral from 2 weeks 6-months post-vaccination in 120 92...
African Americans suffer disproportionately from tobacco-related illness and have more difficulty quitting smoking than other racial/ethnic groups. Previous research indicates that American treatment-seekers are high utilizers of tobacco quitlines, yet cessation rates via quitlines lower relative to whites. The goal the present study is test effectiveness adding a culturally specific, video-based, adjunct standard quitline care. It hypothesized integration an evidence-based intervention...
Marginalized groups in Manitoba, Canada, especially females and people who inject drugs, are overrepresented new HIV diagnoses disproportionately affected by structural disadvantages. Informed syndemic theory, our aim was to understand living with HIV's (PLHIV) gendered intersecting barriers facilitators across the cascade of care before during COVID-19 pandemic. This study co-designed co-led alongside lived experience a research advisory committee. We employed semi-structured interviews...
The escape and growth of Microcoleus vaginatus from alginate pellets onto soil crusts under controlled laboratory conditions were examined. Soil crust samples collected placed in petri dishes. Selected sterilized, three treatmerits established: 75 g m−2 added to sterilized soil, blank unsterilized with no additions. Chlorophyll a readings significantly higher soils. biovolumes highest inoculated soils than untreated filament density was Microcoleus‐inoculated the other two treatments....
Background The COVID-19 pandemic (March 2020-May 2023) had a profound effect around the world with vulnerable people being particularly affected, including worsening existing health inequalities. This article explores impact of on services for First Nations living HIV (FN-PWLE) in Manitoba, Canada. study investigated perceptions both care providers and FN-PWLE through qualitative interviews occurring between July 2020 February 2022 to understand their experience identify lessons learned that...
Reproductive health has been deleteriously affected by poor quality medicines. Emergency contraceptive pills (ECPs) are an important birth control method that women can use after unprotected coitus for reducing the risk of pregnancy. In response to detection ECPs commercially available in Peruvian market we developed a tiered multi-platform analytical strategy. survey assess ECP medicine Peru, 7 out 25 different batches showed inadequate release levonorgestrel dissolution testing or improper...
Nursing home (NH) residents have experienced significant morbidity and mortality to SARS-CoV-2 throughout the pandemic. Vaccines initially curbed NH resident mortality, but antibody levels protection declined with time since vaccination, prompting introduction of booster vaccination. This study assesses humoral immune response vaccination in 85 44 health care workers (HCW) that we followed longitudinally initial BNT162b2 mRNA The findings reveal significantly increased anti-spike,...
Introduction In Manitoba, Canada, there has been an increase in the number of people newly diagnosed with HIV and those not returning for regular care. The COVID-19 pandemic resulted increased sex gender disparities disease risk mortalities, decreased harm reduction services reduced access to healthcare. These health crises intersect drug use poisoning deaths, houselessness other structural social factors most acutely among historically underserved groups. We aim explore barriers...
Abstract Objectives To outline the development and validation of a universal method for quantifying deltamethrin, permethrin alpha‐cypermethrin levels in variety long‐lasting insecticidal mosquito nets. Methods Using HPLC conditions found CIPAC deltamethrin quantification, is based on simple extraction technique sample preparation (heating isooctane at approximately 100 °C 15 min). The was validated linearity, specificity, accuracy, precision, insecticide stability to required time removal....