A5015232451- Bladder and Urothelial Cancer Treatments
- Prostate Cancer Treatment and Research
- Vitamin C and Antioxidants Research
- Estrogen and related hormone effects
- Epigenetics and DNA Methylation
- Sexual Differentiation and Disorders
- Cancer Research and Treatments
- Reproductive System and Pregnancy
- Genomics and Chromatin Dynamics
- Glutathione Transferases and Polymorphisms
- RNA modifications and cancer
- Cancer Genomics and Diagnostics
- Cancer, Hypoxia, and Metabolism
- Neuroendocrine Tumor Research Advances
- Lung Cancer Research Studies
- Hormonal and reproductive studies
- Genomics, phytochemicals, and oxidative stress
- 3D IC and TSV technologies
- Intraperitoneal and Appendiceal Malignancies
- Vitamin D Research Studies
- Nanofabrication and Lithography Techniques
- Histone Deacetylase Inhibitors Research
- Blood properties and coagulation
- Ovarian function and disorders
- Advancements in Photolithography Techniques
Cleveland Clinic
2019-2025
Spelman College
2025
Cleveland Clinic Lerner College of Medicine
2020-2024
Cerner (United States)
2023
Translational Research in Oncology
2023
Case Comprehensive Cancer Center
2022
University of Calcutta
2014-2018
Phages BillyTP (Cluster AY) and MAnor CT) were isolated from soil using Arthrobacter globiformis B-2979 Gordonia rubripertincta NRRL B-16540, respectively, as hosts. The genome of is 53,003 base pairs (bp) contains 96 putative genes, while the 48,333 bp encoding 73 genes. are assigned to actinobacteriophage clusters AY CT, based on gene content similarity (GCS) at least 35%.
Endocrine-driven malignancies, including breast and prostate cancer, are among the most common human cancers. The relationship between sex steroid hormones (eg, androgen, estrogen, progesterone), their cognate receptors, genomic stability lie at center of endocrine-driven cancer development, progression, therapeutic resistance. A variety direct indirect mechanisms have been described that link hormone signaling to loss integrity drives early carcinogenesis. These effects often enriched...
Cigarette smoke (CS) is the strongest risk factor for emphysema. However, mechanism of disease not clear. One reason that each puff CS a complex mixture approximately 4,000 chemicals, and it yet to be known which these chemical(s) are directly involved in pathogenesis lung injury The purpose this study was demonstrate p-benzoquinone (p-BQ) produced lungs CS-exposed guinea pigs causative destruction alveolar cells resulting emphysema prevented by vitamin C. Vitamin C-restricted were subjected...
Urothelial cancer of the renal pelvis (CRP) is predominantly associated with cigarette smoking. However, molecular pathogenesis initiation and progression smoke (CS)-induced CRP unknown. Majority high grade stage at presentation has a recurrence rate even after surgery. Earlier we reported that prolonged treatment (24 weeks) guinea pig model p-benzoquinone (p-BQ), product CS in vivo, produced carcinoma situ pelvis, noninvasive cancer. Since known to induce invasive cancer, investigated...
Glutamyl-prolyl-tRNA synthetase (EPRS1) is a bifunctional aminoacyl-tRNA-synthetase (aaRS) essential for decoding the genetic code. EPRS1 resides, with seven other aaRSs and three noncatalytic proteins, in cytoplasmic multi-tRNA complex (MSC). Multiple MSC-resident aaRSs, including EPRS1, exhibit stimulus-dependent release from MSC to perform noncanonical activities distinct their primary function protein synthesis. Here, we show present both cytoplasm nucleus of breast cancer cells...
The fetal-to-adult hemoglobin switching at about the time of birth involves a shift in expression from γ-globin to β-globin erythroid cells. Effective re-expression fetal can ameliorate sickle cell anemia and β-thalassemia. Despite physiological clinical relevance this switch, its posttranscriptional regulation is poorly understood. Here, we identify Pumilo 1 (PUM1), an RNA-binding protein with no previously reported functions erythropoiesis, as direct regulator switching. PUM1, whose...
Half of all men with advanced prostate cancer (PCa) inherit at least 1 copy an adrenal-permissive HSD3B1 (1245C) allele, which increases levels 3β-hydroxysteroid dehydrogenase (3βHSD1) and promotes intracellular androgen biosynthesis. Germline inheritance the adrenally permissive allele confers worse outcomes in PCa. We investigated whether drives resistance to combined deprivation radiotherapy. Adrenally 3βHSD1 enhanced radiotherapy PCa cell lines xenograft models engineered mimic human...
According to WHO classification system, non-invasive urothelial carcinoma represents in situ (CIS) and dysplasia. Dysplastic urothelium often progresses CIS that further advances (UC). The strongest risk factor for UC is cigarette smoking. However, the pathogenesis of smoke (CS)-induced poorly understood. Earlier we had shown p-benzoquinone (p-BQ), a major toxic quinone derived from p-benzosemiquinone CS vivo, causative various CS-induced diseases. Here, using guinea pig model showed...
You have accessJournal of UrologyBladder Cancer: Basic Research & Pathophysiology II (PD14)1 May 2024PD14-01 ORTHOTOPIC MURINE MODEL OF NEUROENDOCRINE BLADDER CANCER ELUCIDATES POTENTIAL MOLECULAR DRIVERS SMALL CELL (SCBC) Ross Liao, Jarrell Imamura, Hui Ting Ruan Li, Andrew Muskara, Shinjini Ganguly, Chris McFarland, Aysegul Balyimez, Moshe Ornstein, Shilpa Gupta, Jesse McKenney, Eric Klein, Christopher Weight, Nima Almassi, and Omar Mian LiaoRoss Liao , ImamuraJarrell Imamura LiHui Li...
4528 Background: cfDNA can be detected in healthy individuals but higher concentrations are present pts with cancer. MDSC immature immunosuppressive cells that mobilized from bone marrow by tumor-related factors. Higher blood levels have been associated worse outcomes solid tumors including BC. We assessed correlations between and MIBC met Methods: Peripheral BC was collected Streck BCT tubes processed to obtain cf nucleic acid extracts. Total determined fluorimetry. Cell-free DNA fragment...
571 Background: SCBC is an aggressive subtype of bladder cancer with high metastatic potential and few effective treatment options. We developed orthotopic mouse model to understand the development this rare variant identify epigenetic drivers neuroendocrine differentiation. Methods: Lentiviral particles carrying Cre recombinase were produced using Lenti-sgNeo#2/Cre. The bladders Rb1 fl/fl Trp53 Myc LSL/LSL (RPM) mice was transduced expressing lentivirus via transurethral catheterization....
e17084 Background: Around 50% of men with advanced prostate cancer (PCa) have at least one germline copy the adrenal-permissive (1245C) HSD3B1 allele. This allele leads to higher levels steroid biosynthesis enzyme, 3β-hydroxysteroid dehydrogenase (3βHSD1). Inheriting this is linked worse outcomes in PCa. To determine if could be causing early resistance combined androgen deprivation and radiotherapy localized PCa, we studied its role modulating radioresistance. Methods: PCa cell lines were...
e16622 Background: Radiation is an essential part of organ preservation therapy for muscle-invasive BLCA patients. There increasing interest in use immunotherapy this setting and defining biomarkers RS immunity will be crucial to guide patient selection. We investigated whether predicted patients can differentiate TME profiles based on RNA-seq. Methods: Twenty genomically-verified cell lines were profiled with log(TPM+1) normalized RNA-seq counts. Colony forming assays (CFA) each line done...
Metastatic urothelial carcinoma (UC) confers 5-year survivals <20%, encouraging investigation of carcinogenic-mechanisms towards new treatments. UCs only partially activate terminal differentiation programs, e.g., for umbrella cells that line bladder lumen, despite high expression lineage-defining master transcription factors like FOXA1. We interrogated this point-of-failure in UC cells, the endogenous FOXA1 hub, using proteomics and genomics. observed key coactivators, ARID1A, engages to...
4523 Background: Occult MI and met BC may be under-staged. Circulating cfDNA a dynamic, low-cost minimally invasive biomarker. We evaluated correlations between total circulating presence of MIBC BC. hypothesized that the relative abundance low molecular weight would correlate with stage. Methods: Peripheral blood from pts was collected in Streck BCT tubes processed to obtain cf nucleic acid extracts. Total quantity (ng/ml) assessed by fluorimetry. fragment size measured Bioanalyzer DNA...