A5040003780- Asthma and respiratory diseases
- Tracheal and airway disorders
- Inhalation and Respiratory Drug Delivery
- Respiratory Support and Mechanisms
- Cell Adhesion Molecules Research
- Obstructive Sleep Apnea Research
- Ion Channels and Receptors
- Occupational exposure and asthma
- Hematological disorders and diagnostics
- Tissue Engineering and Regenerative Medicine
- Cellular Mechanics and Interactions
- Metal Forming Simulation Techniques
- Allergic Rhinitis and Sensitization
- Neurobiology and Insect Physiology Research
- Powder Metallurgy Techniques and Materials
- Ion channel regulation and function
- Connexins and lens biology
- Fatigue and fracture mechanics
- Collagen: Extraction and Characterization
- Connective tissue disorders research
- Immune cells in cancer
- Chronic Obstructive Pulmonary Disease (COPD) Research
- Airway Management and Intubation Techniques
- 3D Printing in Biomedical Research
- Cholinesterase and Neurodegenerative Diseases
Northeastern University
2019-2023
Boston University
2017
University of Glasgow
1985
Abstract For an airway or a blood vessel to narrow, there must be connected path that links the smooth muscle (SM) cells with each other, and transmits forces around organ, causing it constrict. Currently, we know very little about mechanisms regulate force transmission pathways in multicellular SM ensemble. Here, used extracellular matrix (ECM) micropatterning study two-cell ensemble of cells. Using two-SM cell ensemble, demonstrate (a) ECM stiffness acts as switch regulates whether is...
Targeting inflammation is the central dogma on which current asthma therapy based. Here, we show that a healthy airway can be made to constrict excessively and at faster rate in response same stimulus by increasing stiffness of extracellular matrix, without use inflammatory agents. Our results provide an independent mechanism remodeling sustain hyperreactivity even absence signals.
Inflammation plays a significant role in the development of obesity-related complications, but molecular events that initiate and propagate such inflammation remain unclear. Here, we report mice fed high-fat diet (HFD) for as little 1-3 days show increased differentiation myeloid progenitors into neutrophils monocytes reduced B lymphocyte production bone marrow. Levels neutrophil elastase (NE) nuclear factors CCAAT/enhancer-binding protein α (C/EBPα) growth factor-independent 1 (GFI-1) are...
Extracellular matrix rigidity regulates how smooth muscle cells perceive contractile agonist concentration.
Abstract The current therapeutic approach to asthma focuses exclusively on targeting inflammation and reducing airway smooth muscle force in an effort prevent the recurrence of symptoms. However, treatment is not a cure has little beneficial effect progression asthma. This suggests that there are mechanisms at play likely triggered by eventually become self-sustaining so even when brought back under control, these alternative continue drive hyperreactivity asthmatics. In this study, we...
Abstract We report the existence of a unique mode communication among human smooth muscle cells (SMCs) where they use force to frequency modulate long-range calcium waves. An important consequence this mechanical signaling is that changes in stiffness underlying extracellular matrix can interfere with modulation Ca 2+ waves causing healthy SMCs falsely perceive much higher agonist dose than actually received. This distorted sensing contractile on stiffer matrices absent isolated SMCs, even...
Rationale: Asthma is an inflammatory disease of the airways brought about by persistent inflammation.Even when inflammation under control, asthmatic can still hyperconstrict to a low dose inhaled agonists.This suggests that there are mechanisms at play likely triggered and eventually become self-sustaining so even back these alternative continue drive airway hyperreactivity in asthmatics.One such mechanism has garnered considerable attention irreversible change collagen fibers within wall...
Rationale: Excessive deposition of fibrillar collagen is a pathological feature asthma, and there evidence that suggests accumulation in the airway extracellular matrix (ECM) contributes to disease progression.In healthy lungs, turnover tightly regulated existed replaced by newly synthesized protein approximately 27 days.For be degraded, subset metalloprotease (MMP) enzymes known as collagenases must cleave fibrils into fragments before it can removed from ECM macrophages.However, asthma...