A5068352981- Inflammasome and immune disorders
- Immune Cell Function and Interaction
- IL-33, ST2, and ILC Pathways
- T-cell and B-cell Immunology
- Endoplasmic Reticulum Stress and Disease
- Autophagy in Disease and Therapy
- CAR-T cell therapy research
- Cell death mechanisms and regulation
- Diet, Metabolism, and Disease
- Immune Response and Inflammation
- Helicobacter pylori-related gastroenterology studies
- Immunotherapy and Immune Responses
University of California, Berkeley
2017-2021
University of Washington
2016
The NAIP/NLRC4 inflammasome is a cytosolic sensor of bacteria that activates caspase-1 and initiates potent immune responses. Structural, biochemical, genetic data demonstrate NAIP proteins are receptors for bacterial ligands, while NLRC4 downstream adaptor multimerizes with NAIPs to form an inflammasome. has also been proposed suppress tumor growth, though the underlying mechanism unknown. Further, phosphorylated on serine 533, which was suggested be critical its function. In absence S533...
The innate immune system detects pathogens and initiates adaptive responses. Inflammasomes are central components of the system, but whether inflammasomes provide sufficient signals to activate immunity is unclear. In intestinal epithelial cells (IECs), a lytic form cell death called pyroptosis, leading expulsion release cytokines. Here, we employed genetic show that simultaneous antigen expression inflammasome activation specifically in IECs CD8 + T cells. By elimination direct priming by...
Significance The diverse T-cell receptor (TCR) repertoire is generated by selection of T cells that have undergone TCR-gene recombination during intrathymic development. This process precisely regulated to prevent DNA damage and minimize the escape self-reactive cells. Peripheral with TCRs can be neutralized undergoing further rearrangements, through a known as TCR revision. Although potentially useful source new specificities, revision incurs risk off-target damage. Our work demonstrates...
Abstract The youngest peripheral T cells (recent thymic emigrants [RTEs]) are functionally distinct from naive that have completed postthymic maturation. We assessed the RTE memory response and found RTEs produced less granzyme B than their mature counterparts during infection but proliferated more and, therefore, generated equivalent target killing in vivo. Postinfection, numbers contracted dramatically those of cells, were delayed transition to central memory, displaying impaired...
Abstract The innate immune system detects pathogens and initiates adaptive responses. Inflammasomes are central components of the system, but whether inflammasomes provide sufficient signals to activate immunity is unclear. In intestinal epithelial cells (IECs), a lytic form cell death called pyroptosis, leading expulsion release cytokines. Here we employed genetic show that simultaneous antigen expression inflammasome activation specifically in IECs CD8 + T cells. By elimination direct...
ABSTRACT The NAIP/NLRC4 inflammasome is a cytosolic sensor of bacteria that activates Caspase-1 and initiates potent downstream immune responses. Structural, biochemical, genetic data all demonstrate the NAIP proteins act as receptors for specific bacterial ligands, while NLRC4 adaptor protein multimerizes with NAIPs to form macromolecular structure called an inflammasome. However, several aspects biology remain unresolved. For example, in addition its clear function responding bacteria, has...