The use of tumor necrosis factor antagonists (anti-TNF) has become a usual practice to treat various inflammatory diseases. Although indicated for the treatment psoriasis, anti-TNF may paradoxically trigger psoriasiform condition. We present case female patient who, during infliximab rheumatoid arthritis, developed psoriasis. In an attempt switch class, we observed cumulative worsening lesions requiring suspension immunobiological agent and introduction other drugs clinical control....

Childhood linear immunoglobulin A dermatosis is a rare autoimmune vesiculobullous disease. It results in deposition of autoantibodies (immunoglobulin A) against antigens the basal membrane zone, leading to subepidermal cleavage. Additional depositions G and complement-3 might occur. still debated whether concomitant findings immunoglobulins should be considered subtype this or new entity. Further studies are needed recognize clinical variant.

Linear IgA dermatosis has been increasingly associated with inflammatory bowel diseases, particularly ulcerative colitis. A 13-year-old male patient an 11-month history of colitis developed vesicles, pustules and erosions on the skin face, trunk buttocks in oral mucosa. The work-up revealed a neutrophil-rich sub-epidermal bullous disease linear deposition along dermoepidermal junction, establishing diagnosis dermatosis. experienced unsatisfactory partial control intestinal symptoms despite...

Woolly hair nevus is a rare condition characterized by structural anomaly of the hair, restricted to certain areas scalp. The becomes coiled and slightly hypopigmented. term woolly refers changes that affect all scalp has hereditary character. We present case nevus, developed at age 2 years, associated with dental diastema verrucous epidermal nevus.

The authors report a case of ectopic cutaneous schistosomiasis in 35 year-old female who presented clustered reddish macules and papules on the left buttock. diagnosis was not suspected during clinical evaluation required visualization Schistosoma mansoni eggs sections tissue.

The classification of cutaneous lymphomas is multidisciplinary and requires the correlation between clinical, histopathological, immunohistochemical, molecular diagnostic elements. In this article, we present four different cases CD30-positive T-cell lymphoma with manifestations. We compare definitive diagnosis papulosis lymphomatoid type C, primary anaplastic large lymphoma, systemic secondary skin involvement, mycosis fungoides cell transformation, highlighting importance...

matrix metalloproteinase-9 and -12 derived from tumor cells, fibroblasts, macrophages may be relevant to the partial elimination of tumor, by degradation collagen elastic fibers. 4 When superficially located, pilomatricoma is accelerated virtue epidermal catharsis mechanisms.

We report the case of an 11-year-old male patient with a histopathological and immunohistochemical diagnosis dermatofibroma atypical clinical presentation on right forearm. Although is considered benign skin tumor, some its differential diagnoses, such as dermatofibrosarcoma protuberans malignant fibrous histiocytoma, are truly aggressive. Lesions aspects topology associated specific variants criteria for complete tumor excision.

O carcinoma de células escamosas pigmentado é variedade rara escamosas, havendo apenas 13 casos localização na pele relatados literatura inglesa, cinco latino-americana e nenhum caso brasileira. Neste trabalho, os autores relatam um da pele, destacando aspectos clínicos, histopatológicos imuno-histoquímicos.

Frontal fibrosing alopecia (FFA) is a progressive frontotemporal hairline recession with eyebrow loss. Facial papules are present in up to 14% of FFA cases and can start facial flushes. Nevertheless, these flushes commonly associated rosacea, much more prevalent disease. In this case, woman had, at first, clinical histopathological findings rosacea was treated ivermectin 1% cream no improvement. She returned reporting new the frontal region, reaching hairline. Trichoscopy scalp showed mild...