Yongchun Li

ORCID: 0000-0003-1761-3447
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About
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Research Areas
  • Liver Disease Diagnosis and Treatment
  • Diet and metabolism studies
  • Gut microbiota and health
  • Chronic Obstructive Pulmonary Disease (COPD) Research
  • Diet, Metabolism, and Disease
  • S100 Proteins and Annexins
  • Immune Response and Inflammation
  • Inflammation biomarkers and pathways
  • Respiratory Support and Mechanisms
  • Protease and Inhibitor Mechanisms
  • Atherosclerosis and Cardiovascular Diseases
  • Neonatal Respiratory Health Research
  • Antibiotic Use and Resistance
  • Peptidase Inhibition and Analysis
  • Pneumonia and Respiratory Infections
  • Antibiotic Resistance in Bacteria
  • Antimicrobial Peptides and Activities
  • Antimicrobial agents and applications
  • Adipokines, Inflammation, and Metabolic Diseases
  • Protein Hydrolysis and Bioactive Peptides
  • Psoriasis: Treatment and Pathogenesis
  • Pharmacological Effects of Natural Compounds

Qingdao University
2022-2024

Qingdao Municipal Hospital
2022-2024

Southern Medical University
2013-2022

University of California, Davis
2020-2022

South China University of Technology
2022

Zhujiang Hospital
2020-2022

University of California Davis Medical Center
2020

Zhengzhou University
2020

Jinzhou Medical University
2008

Hanzhong People's Hospital
2005

Probiotic VSL#3 is used to treat ulcerative colitis. This study examines the effect of in non-alcoholic steatohepatitis (NASH) that has liver carcinogenic potential.Western diet (WD)-fed wild-type (WT) mice do not have hepatic inflammation with lymphocyte infiltration and potential were for baseline comparison. Age-, sex-, diet-matched bile acid (BA) receptor farnesoid X (FXR) knockout (KO) mice, which developed severe NASH had cancer development, supplemented without 7 months. All...

10.21037/hbsn.2019.09.07 article EN HepatoBiliary Surgery and Nutrition 2020-03-23

Abstract Background Chronic consumption of high sugar and fat diet associated with liver inflammation cognitive decline. This paper tests a hypothesis that the development resolution diet-induced nonalcoholic fatty disease (NAFLD) has an impact on neuroplasticity cognition. Methods C57BL/6 wild-type mice were fed either healthy control (CD) or fructose, palmitate, cholesterol (FPC)-enriched since weaning. When 3-months old, FPC diet-fed randomly assigned to receive FPC-enriched without 6%...

10.1186/s40364-020-00239-8 article EN cc-by Biomarker Research 2020-11-06

Antibiotic-resistant bacteria are becoming a serious threat to public health worldwide. To address this problem, we have developed multifunctional peptide (MFP)-coated silver nanoparticles (MFP@AgNPs) for antibacterial studies. MFPs, which can physically adsorb AgNPs

10.1039/d0ra05640e article EN cc-by-nc RSC Advances 2020-01-01

Reversion-inducing cysteine-rich protein with Kazal motifs (RECK), a recently discovered inhibitor of matrix metalloproteinase (MMP). There is large number chronic obstructive pulmonary disease (COPD) patients worldwide; however, the role RECK on COPD has not been studied. This study explored expression in and its effect neutrophil function to provide new scientific basis for prevention treatment COPD.

10.1159/000536021 article EN International Archives of Allergy and Immunology 2024-01-01

Obesity and malnutrition both cause dysbiosis dampen retinoic acid (RA) signaling pathways, which play pivotal roles in biological processes. The current study evaluates a hypothesis that colitis-associated also has systemic negative impacts on RA signaling. Thus, we studied the effects of inflammation, under vitamin A-sufficient condition, using mouse colitis models induced by dextran sulfate sodium. That data showed intestinal inflammation resulted reduced liver, brain, gut, adipose...

10.3390/nu14142788 article EN Nutrients 2022-07-06

Objective To investigate the characteristics of distribution and antimicrobial resistance Klebsiella pneumoniae in our hospital 2012.Methods Disk diffusion antibiotic sensitivity testing was used to determine susceptibility,and results were judged according American CLSI2012 standard.The WHONET5.4 software SPSS13.0 analyze data.Results Of all clinical isolates,Klebsiella strains accounted for 9.6%,12.4%,12.4%,and 12.8%; rate ESBLs 38.2%,24.7%,36.3%,and 36.9% four quarters,respectively.The...

10.3760/cma.j.issn.1007-1245.2013.09.005 article EN Guoji yiyao weisheng daobao 2013-05-01

Matrix metalloproteinase(MMP) is a kind of highly conservative interior-contacted enzyme that depends on calcium and zinc ion which can degrade nearly all the extracellular matrix protein. MMP-9 participates in destruction, remould matrix, as well chemotaxis lung organization plays influential roles aspect formation, development, inflammation continuance chronic obstructive pulmonary disease(COPD). Seeking for inhibitors posses smaller or less poisonous side effects specificity to improve...

10.3760/cma.j.issn.1673-436x.2008.17.012 article EN Chinese Journal of Asthma 2008-09-05

Abstract Background: Chronic consumption of high sugar and fat diet associated with liver inflammation cognitive decline. This paper tests a hypothesis that the development resolution diet-induced nonalcoholic fatty disease (NAFLD) has an impact on neuroplasticity cognition. Methods: C57BL/6 wild-type mice were fed either healthy control (CD) or fructose, palmitate, cholesterol (FPC)-enriched since weaning. When 3-months old, FPC diet-fed randomly assigned to receive FPC-enriched without 6%...

10.21203/rs.3.rs-59456/v1 preprint EN cc-by Research Square (Research Square) 2020-08-27

Abstract Background: Chronic consumption of high sugar and fat diet associated with liver inflammation cognitive decline. This paper tests a hypothesis that the development resolution diet-induced nonalcoholic fatty disease (NAFLD) has an impact on neuroplasticity cognition. Methods: C57BL/6 wild-type mice were fed either healthy control (CD) or fructose, palmitate, cholesterol (FPC)-enriched since weaning. When 3-months old, FPC diet-fed randomly assigned to receive FPC-enriched without 6%...

10.21203/rs.3.rs-59456/v2 preprint EN cc-by Research Square (Research Square) 2020-10-29

Abstract Objective Reversion-inducing cysteine-rich protein with Kazal motifs (RECK), a new inhibitor of matrix metalloproteinase (MMP), plays vital role in tumor invasion. Patients chronic obstructive pulmonary disease (COPD) are at higher risk developing lung cancer, however, the RECK on COPD has not been studied. This study explored expression patients and its effect neutrophil function to provide scientific basis for prevention treatment COPD. Method Fifty acute exacerbation fifty...

10.21203/rs.3.rs-2126801/v1 preprint EN cc-by Research Square (Research Square) 2022-10-10
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