A5077801823- Ion Transport and Channel Regulation
- Ion channel regulation and function
- Sirtuins and Resveratrol in Medicine
- Diet and metabolism studies
- Adipose Tissue and Metabolism
- Biochemical effects in animals
- Cardiac electrophysiology and arrhythmias
- Autophagy in Disease and Therapy
- Hormonal Regulation and Hypertension
- Metabolism and Genetic Disorders
- Drug Transport and Resistance Mechanisms
- Amino Acid Enzymes and Metabolism
- Nitric Oxide and Endothelin Effects
- Hormonal and reproductive studies
- Renin-Angiotensin System Studies
- Receptor Mechanisms and Signaling
- Electrolyte and hormonal disorders
- Neuroscience and Neuropharmacology Research
- Liver Disease Diagnosis and Treatment
- Sexual function and dysfunction studies
- Diet, Metabolism, and Disease
- Calcium signaling and nucleotide metabolism
- Phytochemicals and Antioxidant Activities
- Neurotransmitter Receptor Influence on Behavior
- Magnesium in Health and Disease
Universidade do Porto
2013-2024
University of Coimbra
2012-2024
AC Camargo Hospital
2024
Centro Universitário Maurício de Nassau
2024
University of Minho
2007-2022
Centre for Health Technology and Services Research
2019-2021
Rede de Química e Tecnologia
2020
i3S - Instituto de Investigação e Inovação em Saúde, Universidade do Porto
2015
Instituto Português de Oncologia Francisco Gentil
2001-2011
Institute of Pharmacology
2002-2009
Insulin resistance is a major predictor of the development metabolic disorders. Sirtuins (SIRTs) have emerged as potential targets that can be manipulated to counteract age-related diseases, including type 2 diabetes. SIRT2 has been recently shown exert important effects, but whether regulates insulin sensitivity in hepatocytes currently unknown. The aim this study investigate possibility and elucidate underlying molecular mechanisms. Here, we show downregulated insulin-resistant livers, was...
Type 1 diabetes mellitus is responsible for metabolic dysfunction, accompanied by chronic inflammation, oxidative stress, and endothelium often associated with impaired wound healing. Phenol-rich food improves vascular function, contributing to prevention. This study has evaluated the effect of phenol-rich beverage consumption in diabetic rats on healing, through angiogenesis, stress modulation. A wound-healing assay was performed streptozotocin-induced Wistar drinking water, 5% ethanol,...
Blueberries, red fruits enriched in polyphenols and fibers, are envisaged as a promising nutraceutical intervention plethora of metabolic diseases. Prediabetes, an intermediate state between normal glucose tolerance type 2 diabetes, fuels the development complications, including hepatic steatosis. In previous work, we have demonstrated that blueberry juice (BJ) supplementation benefits glycemic control lipid profile, which was accompanied by amelioration mitochondrial bioenergetics. The...
The aim of this study was to investigate whether the effects aging on oxidative stress markers and expression major oxidant antioxidant enzymes associate with impairment renal function increases in blood pressure. To explore this, we determined age-associated changes lipid peroxidation (urinary malondialdehyde), plasma urinary hydrogen peroxide (H(2)O(2)) levels, as well H(2)O(2) production, young (13 weeks) old (52 male Wistar Kyoto (WKY) rats. Urinary levels production by cortex medulla...
Autophagy-related gene 3 (ATG3) is an enzyme mainly known for its actions in the LC3 lipidation process, which essential autophagy. Whether ATG3 plays a role lipid metabolism or contributes to non-alcoholic fatty liver disease (NAFLD) remains unknown.By performing proteomic analysis on livers from mice with genetic manipulation of hepatic p63, regulator acid metabolism, we identified as new target downstream p63. was evaluated samples patients NAFLD. Further, performed human hepatocyte cell...
A valva aórtica possui três válvulas (ou cúspides). Essas são chamadas de semilunares devido à sua forma, e cada uma delas ajuda a regular o fluxo sangue do ventrículo esquerdo coração para aorta, prevenindo refluxo após contração ventricular, assim, colaborando que circulação sistêmica sanguínea mantenha seu direcionamento sentido único pressão adequada funcionamento. Dentre as diversas patologias comumente acometem essa estrutura, destaca-se estenose valvar (EAo) consiste no estreitamento...
We studied the molecular events set into motion by stimulation of D 1 -like receptors downstream Na + -K -ATPase, while measuring apical-to-basal ouabain-sensitive, amphotericin B-induced increases in short-circuit current opossum kidney (OK) cells. The receptor agonist SKF-38393 decreased -ATPase activity (IC 50 , 130 nM). This effect was prevented antagonist SKF-83566, overnight cholera toxin treatment, protein kinase A (PKA) H-89, or PKC chelerythrine, but not mitogen-activated PK...
Erectile dysfunction (ED) is a prevalent complication of diabetes, and oxidative stress an important feature diabetic ED. Oxidative stress-induced damage plays pivotal role in the development tissue alterations. However, deleterious effects corpus cavernosum with progression diabetes remain unclear. The aim this study was to evaluate systemic penile status early late stages diabetes.Male Wistar streptozotocin-diabetic rats (and age-matched controls) were examined 2 (early) 8 weeks (late)...
Nonalcoholic fatty liver disease (NAFLD), a condition strongly associated with obesity and insulin resistance, is characterized by hepatic lipid accumulation activation of the endoplasmic reticulum (ER) stress response. The sirtuin 2 (SIRT2) protein deacetylase emerging as new player in metabolic homeostasis, but its role development steatosis link ER remains unknown. SIRT2-knockout (SIRT2-KO) wild-type mice were fed either control or high-fat diet (HFD) for 4 weeks. Genetic manipulation...
This study evaluated the transduction pathway associated with type 3 Na + /H exchanger (NHE3) activity-induced inhibition during dopamine D receptor activation in immortalized renal proximal tubular epithelial cells from spontaneously hypertensive rat. The agonist 7-OH-DPAT decreased NHE3 activity, which was prevented by 2 -like antagonist S-sulpiride, pertussis toxin (PTX; overnight treatment), and PKC inhibitor chelerythrine, but not cholera (overnight MAPK PD-098059, or p38 SB-203580. PKA...