A5046533838- Dialysis and Renal Disease Management
- Nutrition and Health in Aging
- Muscle metabolism and nutrition
- Parathyroid Disorders and Treatments
- Iron Metabolism and Disorders
- Hormonal and reproductive studies
- Diet and metabolism studies
- Metabolism and Genetic Disorders
- Potassium and Related Disorders
- Metabolomics and Mass Spectrometry Studies
- Body Composition Measurement Techniques
- Health Policy Implementation Science
- Bipolar Disorder and Treatment
- Adipose Tissue and Metabolism
- Obesity and Health Practices
- Restless Legs Syndrome Research
- Folate and B Vitamins Research
- Ethics in Clinical Research
- Electrolyte and hormonal disorders
- Muscle Physiology and Disorders
- Pharmacological Effects and Assays
- Pharmacology and Obesity Treatment
- Pharmacological Effects and Toxicity Studies
- Biomedical and Engineering Education
- Hypothalamic control of reproductive hormones
Harbor–UCLA Medical Center
2014-2024
UCLA Medical Center
2013-2024
UCLA Clinical and Translational Science Institute
2021
The Lundquist Institute
2008-2018
University of California, Los Angeles
2001-2018
Biomed Research Institute
2012-2018
Healthy African American Families II
2018
Charles R. Drew University of Medicine and Science
1998-2018
Southern California Clinical and Translational Science Institute
2016
Los Angeles Medical Center
2001-2014
Testosterone increases muscle mass and strength regulates other physiological processes, but we do not know whether testosterone effects are dose dependent requirements for maintaining various androgen-dependent processes similar. To determine the of graded doses on body composition, size, strength, power, sexual cognitive functions, prostate-specific antigen (PSA), plasma lipids, hemoglobin, insulin-like growth factor I (IGF-I) levels, 61 eugonadal men, 18–35 yr, were randomized to one five...
Maintenance hemodialysis (MHD) patients with larger body or fat mass have greater survival than normal to low mass. We hypothesized that mid-arm muscle circumference (MAMC), a conveniently measured surrogate of lean (LBM), has stronger association clinical outcomes triceps skinfold (TSF), mass.The associations TSF, MAMC, and serum creatinine, another LBM surrogate, baseline short form 36 quality-of-life scores 5-year were examined in 792 MHD patients. In randomly selected subsample 118...
The effects of T supplementation on insulin sensitivity, inflammation-sensitive markers, and apolipoproteins remain poorly understood. We do not know whether T's plasma lipids, apolipoproteins, sensitivity are dose dependent, or significant anabolic can be achieved at doses that adversely affect these cardiovascular risk factors. To determine the different T, 61 eugonadal men, 18–35 yr age, were randomly assigned to 1 5 groups receive monthly injections long-acting GnRH agonist suppress...
Epidemiologic studies show an association between higher predialysis serum phosphorus and increased death risk in maintenance hemodialysis (MHD) patients. The hypothesis that dietary intake content per gram of protein are each associated with mortality MHD patients was examined.
Maintenance hemodialysis (MHD) patients often have protein-energy wasting, poor health-related quality of life (QoL), and high premature death rates, whereas African-American MHD greater survival than non-African-American patients. We hypothesized that QoL scores their nutritional correlates a bearing on racial disparities
Abstract Background This study used Community Partnered Participatory Research (CPPR) to address low participation of racial and ethnic minorities in medical research the lack trust between underrepresented communities researchers. Methods Using a community academic partnership July 2012, residents South Los Angeles neighborhood were exposed recruitment strategies: referral by word‐of‐mouth, agencies, direct marketing, extant participants. Results Among 258 members strategies, 79.8%...
Maintenance hemodialysis (MHD) patients reportedly display reduced daily physical activity (DPA) and performance. Low decreased performance are each associated with worse outcomes in chronic kidney disease patients. Although might be expected to related, few studies have examined such relationships MHD patients, methods for examining often utilized questionnaires rather than monitors. We hypothesized that correlated other even relatively healthier patients.Daily activity, 6-min walk distance...
Maintenance hemodialysis (MHD) patients often have impaired quality of life (QOL), anxiety, depression, and reduced daily physical activity (DPA) performance. The contributions these latter factors to QOL in MHD are poorly understood. We examined the association with DPA, performance.Seventy-two relatively healthy adult patients, vintage ≥6 months, 39 normals similar age range gender distribution were studied. was assessed using Kidney Disease Quality Life-Short Form (KDQOL-SF). Anxiety...
Serum transferrin, estimated by total iron-binding capacity (TIBC), may be a marker of protein-energy wasting (PEW) in maintenance hemodialysis (MHD) patients. We hypothesized that low TIBC or its fall over time is associated with poor clinical outcomes. In 807 MHD patients prospective 5-year cohort, associations and changes outcomes were examined after adjustment for case-mix markers iron stores malnutrition-inflammation including serum interleukin-6, ferritin. Patients ≥250 mg/dl had...
<i>Background:</i> Racial/ethnic disparities prevail among hemodialysis patients. We hypothesized that significant differences exist between Black and non-Hispanic Hispanic White patients in nutritional status, dietary intake inflammation, they account for racial survival disparities. <i>Methods:</i> In a 6-year (2001–2007) cohort of 799 patients, we compared diet surrogates nutritional-inflammatory status their mortality-predictabilities 279 Blacks 520 Whites using...
Low serum albumin is common and associated with protein-energy wasting, inflammation, poor outcomes in maintenance hemodialysis (MHD) patients. We hypothesized that in-center (in dialysis clinic) provision of high-protein oral nutrition supplements (ONS) tailored for MHD patients combined anti-oxidants anti-inflammatory ingredients or without an appetite stimulator (pentoxifylline, PTX) well tolerated can improve concentration.Between January 2008 June 2010, 84 adult hypoalbuminemic (albumin...
Background: Inadequate protein intake and hypoalbuminemia, indicators of protein-energy wasting, are among the strongest mortality predictors in hemodialysis patients. Hemodialysis patients frequently counseled on dietary phosphorus restriction, which may inadvertently lead to decreased intake. We hypothesized that, hypoalbuminemic patients, provision high-protein meals during combined with a potent binder increases serum albumin without raising levels. Methods: conducted randomized...