A5086790952- Genomics and Chromatin Dynamics
- Chromosomal and Genetic Variations
- Cancer-related gene regulation
- Genomics and Phylogenetic Studies
- Protein Degradation and Inhibitors
- Cancer Genomics and Diagnostics
- Prenatal Screening and Diagnostics
- Single-cell and spatial transcriptomics
- Chromatin Remodeling and Cancer
- Genetic factors in colorectal cancer
- Molecular Biology Techniques and Applications
- Cancer Cells and Metastasis
- Genomic variations and chromosomal abnormalities
Weatherford College
2023
Washington University in St. Louis
2022
National University Cancer Institute, Singapore
2022
National University of Singapore
2022
Rutgers, The State University of New Jersey
2020
Topologically associating domains, or TADs, are functional units that organize chromosomes into 3D structures of interacting chromatin. TADs play an important role in regulating gene expression by constraining enhancer-promoter contacts and there is evidence deletion TAD boundaries leads to aberrant neighboring genes. While the mechanisms formation have been well-studied, current knowledge on patterns evolution across species limited. Due integral regulation, their structure organization...
Abstract Mutations in the DNA mismatch repair gene MSH2 are causative of microsatellite instability (MSI) multiple cancers. Here, we discovered that besides its well-established role repair, exerts a novel epigenomic function gastric cancer. Unbiased CRISPR-based mass spectrometry combined with genome-wide CRISPR functional screening revealed early-stage cancer genomic binding is not randomly distributed but rather associated specifically tumor-associated super-enhancers controlling...
Abstract Circulating tumor DNA (ctDNA) in peripheral blood has been used to predict prognosis and therapeutic response for triple-negative breast cancer (TNBC) patients. However, previous approaches typically use large comprehensive panels of genes commonly mutated across all cancers. Given the reduction sequencing costs decreased turnaround times associated with panel generation, objective this study was assess custom micro-panels tracking disease predicting clinical outcomes patients TNBC....
Abstract Topologically associating domains, or TADs, are functional units that organize chromosomes into 3D structures of interacting chromatin. TADs play an important role in regulating gene expression by constraining enhancer-promoter contacts; there is evidence deletion TAD boundaries leads to aberrant neighboring genes. While the mechanisms formation have been well-studied, current knowledge on extent conservation across species inconclusive. Due integral regulation, their structure and...