A5024233976- Cerebrospinal fluid and hydrocephalus
- Traumatic Brain Injury and Neurovascular Disturbances
- Fetal and Pediatric Neurological Disorders
- Advanced Neuroimaging Techniques and Applications
- NMR spectroscopy and applications
- Neurosurgical Procedures and Complications
- Genetic and Kidney Cyst Diseases
- Intracerebral and Subarachnoid Hemorrhage Research
- Head and Neck Surgical Oncology
- Advanced MRI Techniques and Applications
- Spinal Dysraphism and Malformations
- Atomic and Subatomic Physics Research
- Neurological disorders and treatments
- Hydraulic Fracturing and Reservoir Analysis
- Seismic Imaging and Inversion Techniques
- Lattice Boltzmann Simulation Studies
University of California, San Diego
2020-2024
University of California System
2023
The monitoring of intracranial pressure (ICP) fluctuations, which is needed in the context a number neurological diseases, requires insertion sensors, an invasive procedure with considerable risk factors. Intracranial fluctuations drive wave-like pulsatile motion cerebrospinal fluid (CSF) along compliant spinal canal. Systematically derived simplified models relating ICP resulting CSF flow rate can be useful enabling indirect evaluations former from non-invasive magnetic resonance imaging...
Forced respirations reportedly have an effect on CSF movement in the spinal canal. We studied respiratory-related motion during normal respiration.Six healthy subjects breathed at their rate with a visual guide to ensure unchanging rhythm. Respiratory-gated phase-contrast MR flow images were acquired 5 selected axial planes along spine. At each level, we computed voxelwise canal, together associated stroke volume. From these data, periodic volume changes of segments. A phantom was used...
<h3>BACKGROUND AND PURPOSE:</h3> Recent flow dynamics studies have shown that the eccentricity of spinal cord affects magnitude and characteristics slow bulk motion CSF in subarachnoid space, which is an important variable solute transport along canal. The goal this study was to investigate how anatomic differences among subjects affect flow. <h3>MATERIALS METHODS:</h3> T2-weighted images were obtained 4 repeated 1 subject after repositioning. velocity calculated from phase-contrast MR for 7...
This in vitro study aims at clarifying the relation between oscillatory flow of cerebrospinal fluid (CSF) cerebral aqueduct, a narrow conduit connecting third and fourth ventricles, corresponding interventricular pressure difference. Dimensional analysis is used designing an anatomically correct scaled model aqueduct flow, with physical similarity maintained by adjusting frequency properties working fluid. The time-varying difference across to given rate measured parametric ranges covering...
This paper addresses the pulsating motion of cerebrospinal fluid in aqueduct Sylvius, a slender canal connecting third and fourth ventricles brain. Specific attention is given to relation between instantaneous values flow rate interventricular pressure difference, needed clinical applications enable indirect evaluations latter from direct magnetic-resonance measurements former. An order-of-magnitude analysis accounting for slenderness used simplifying description. The boundary-layer...
<h3>BACKGROUND AND PURPOSE:</h3> Measuring transmantle pressure, the instantaneous pressure difference between lateral ventricles and cranial subarachnoid space, by intracranial sensors has limitations. The aim of this study was to compute noninvasively with a novel nondimensional fluid mechanics model in volunteers identify differences related age aqueductal dimensions. <h3>MATERIALS METHODS:</h3> Brain MR images including cardiac-gated 2D phase-contrast imaging fast-spoiled gradient...
Abstract Background: The cerebrospinal fluid filling the ventricles of brain moves with a cyclic velocity driven by transmantle pressure, or instantaneous pressure difference between lateral and cerebral subarachnoid space. This dynamic phenomenon is particular interest for understanding ventriculomegaly in cases normal hydrocephalus (NPH). magnitude small, on order few Pascals, thereby hindering direct vivo measurements. To complement previous computational efforts, we perform here, first...
This in vitro study aims at clarifying the relation between oscillatory flow of cerebrospinal fluid (CSF) cerebral aqueduct and interventricular pressure difference over range conditions commonly encountered healthy subjects. Dimensional analysis is used designing a scaled model flow, with physical similarity maintained by adjusting frequency properties working fluid. The experiments include an anatomically correct shape determined from high-resolution magnetic resonance imaging (MRI). A...