A5004318042- Hepatitis C virus research
- Liver Disease Diagnosis and Treatment
- Hepatitis B Virus Studies
- Liver Disease and Transplantation
- HIV/AIDS drug development and treatment
- Blood groups and transfusion
- Animal Virus Infections Studies
- Cytomegalovirus and herpesvirus research
- Viral Infections and Immunology Research
- Systemic Lupus Erythematosus Research
- Immune Cell Function and Interaction
- Cancer Mechanisms and Therapy
- Transplantation: Methods and Outcomes
- Organ Transplantation Techniques and Outcomes
- Biosimilars and Bioanalytical Methods
- T-cell and B-cell Immunology
- interferon and immune responses
Erasmus MC
2016-2019
University Health Network
2018-2019
University of Toronto
2018-2019
Toronto General Hospital
2018-2019
Objective Mucosal-associated invariant T (MAIT) cells comprise a subpopulation of that can be activated by bacterial products and cytokines to produce IFN-γ. Since little is known on MAIT during HCV infection, we compared their phenotype function in comparison HIV HCV/HIV co-infected patients, determined the effect IFN-α-based direct-acting antiviral therapy patients. Methods Blood samples from patients with chronic (CHCV), virologically suppressed HIV, acute co-infection (AHCV/HIV) healthy...
In order to expand hepatitis C virus (HCV) screening, a change in the diagnostic paradigm is warranted improve accessibility and decrease costs, such as utilizing dried blood spot (DBS) collection. our study, from 68 patients with chronic HCV infection was spotted onto DBS cards stored at following temperatures for one week: -80 °C, 4 21 37 alternating °C °C; assess whether temperature during transportation would affect sensitivity. Sample eluted tested antibodies (HCV-Ab) core antigen...
Summary Background In the era of highly effective direct‐acting antivirals (DAAs) for treatment patients with chronic hepatitis C virus (HCV) infection, ribavirin (RBV) is still considered beneficial in certain patients. Aim To assess association between RBV steady‐state plasma levels and sustained virological response (SVR). Methods Consecutive HCV‐infected treated DAAs plus from four Dutch academic medical centres were enrolled. prospectively measured at week 8 using validated assays....
Introduction: Detection of vascular complications in the first post-operative week after liver transplantation are very important. In particular an early diagnosis hepatic artery thrombosis is essential decision-making to go for re-intervention or re-liver transplantation. Therefore abdominal sonography performed several times week, look patency artery, portal vein and veins. Hand-held devices might be expected facilitate bedside sonography. this study we compared with regular machines,...
Background: Non-invasive evaluation of liver fibrosis is important in determining prognosis patients with chronic hepatitis B (HBV) and C (HCV) virus infection. Transient elastography (TE) (FibroScan; Echosens, Paris, France) a well-established method for assessment stiffness (LS). Point shear wave (pSWE) (ElastPQ, Philips) new technique that measures the speed to determine LS. This could result more accurate due real time imaging. Our aim was if pSWE comparable TE
Potent direct-acting antivirals (DAAs) for treatment of chronic hepatitis C virus (HCV) infection have reduced the need on-treatment monitoring. Currently, response and outcome are determined by HCV RNA testing. A less expensive alternative to verify viral replication is core antigen (HCV Ag). The aim this study was determine if Ag can be used initial confirmation viremia, monitoring determination SVR in patients with receiving DAA treatment. To evaluate role confirming SVR, treated DAAs...