Мақалада:қазақтың ақбас ірі қара мал тұқымының бұқашықтары және «Москалевское» ЖШС, «АФ Диевское» 497 бас әулиекөл туралы айтылған. Ірі малының ет өнімділігінің генетикалық негізін анықтау шаруашылығы үшін маңызды. Бұл мақаланың мақсаты – қазақтың тұқым өнімділігі негізінде жатқан құрылымға жан-жақты шолу жасау, гендер арасындағы күрделі өзара әрекеттесуді түсіндіру. Алдыңғы зерттеулерді талдай қорытындылай келе, кемшіліктер анықталып, болашақ зерттеулерге бағыттар ұсынылды. Мақалада...

The purpose of the research is to study association polymorphic variants Toll-Like Receptor 9 (TLR9), Mannose-Binding Lectin 1 (MBL1), and Lactoferrin (LTF) genes with incidence chlamydia, brucellosis mastitis in Holstein cows. Samples cows established diagnoses brucellosis, were characterized by nature correspondence observed frequencies genotypes theoretically expected Hardy Weinberg law, percentage comparison control group healthy animals, as well distribution relative alleles studied...

Мақалада сандық белгілерінің локусымен ассоцияцияланған бір нуклеотидті полиморфизмнің аллельдерін арттыратын қазақ ақбас және әулиекөл ірі қара малдарының ет өнімділігін болжау мүмкіндіктерін бағалау нәтижелері келтірілген. Тұқымдардың әрқайсысы үшін 4 полиморфты аймақ таңдалынды. Мақсатты таңдауда альтернативті аллельдің кездесу жиілігі жоғары (кем дегенде 15%), геном мен гендердің әртүрлі функционалды аймақтарында орналасуы, хромосомалар бойынша таралуы, сондай-ақ белгілі локусына...

Bacterial and viral infections affect the welfare of animals lead to large economic losses in dairy cattle breeding due decreased productive indicators increased culling rates. In modern farming, farmers are looking for effective solutions prevent minimize infectious disease risks. To this end, most relevant study field is search gene sites that impact production health. This aimed determine nature distribution relative frequencies alleles genotypes polymorphic prolactin (PRL) nitric oxide...

The study aimed to determine the effectiveness of use genetic markers in cattle Kazakh white-headed breed identified using a genome-wide association study. object was livestock 790 bulls bred breeding farms Republic Kazakhstan. adheres rigorous ethical standards, with all procedures approved by national scientific council center for state and technical expertise science committee ministry higher education Kazakhstan, ensuring welfare treatment animals involved. Genotypes were determined gene...

The work aims to analyze the associations of polymorphic variants PRL and BLG genes with resistance susceptibility mastitis in Holstein cows. experimental study consisted selection biomaterial samples from 250 heads cows aged 3 years divided into two groups (healthy a confirmed diagnosis mastitis). determination animal genotypes was carried out using polymerase chain reaction restriction fragment length polymorphism. nature association gene resistance/increased risk established significant...

The growth hormone (GH) gene is a promising candidate for marker-assisted selection in livestock breeding, but its polymorphic variants exhibit inconsistent phenotypic effects across different breeds and populations. investigation of the rs41923484 SNP GH, which leads to Val Leu substitution at position 157 (Val157Leu), revealed structural functional differences protein. 157Leu isoform more compact, potentially reducing accessibility sites receptor interactions, affecting efficiency...

Background and Aim: The market demand for the quality of milk dairy products, in particular terms such indicators as fat content, amount composition protein, etc., is growing. Thus, need selection herds using genetic markers associated with qualitative traits productivity becoming urgent. This study aimed to determine preferred undesirable genotypes AluI polymorphism growth hormone gene SnaBI insulin-like factor-1 black-and-white breed. animals were determined by polymerase chain...

Runs of homozygosity (ROH) are contiguous stretches homozygous genotypes that passed from parents to their offspring. ROHs suitable for determining population history, inbreeding rates, and the genetic relationships between individuals in populations, as well detect candidate genes responsible economic traits farm animals. In this study, we observed Kazakh white-headed (KWh) cattle breed (ROH n = 55,976) had a higher number ROH compared Auliekol (AK) 13,137). When calculating mean length...

Technologies for genetic labeling of economically useful traits using polymorphic variants genes that control the rate growth and development animals make it possible to assess potential an animal immediately after birth, which significantly reduces time financial costs. This study aimed identify paired combinations hormone, hormone receptor, insulin-like factor-1 associated with meat productivity in related breeds cattle direction: Hereford, Kazakh white-headed, Aberdeen Angus, Auliekol....

This article provides an overview of modern genetic technologies for improving production traits and predicting breeding value in beef cattle. In particular, marker-assisted selection the most promising is selectionby desirable genotypes genes myostatin (MSTN), calpain (CAPN), calpastatin (CAST), growth hormone (GH), leptin (LEP), thyroglobulin (TG), fatty acid binding protein (FABP), retinoic C-receptor (RORC), diacyl-glycerol acyltransferase (DGATI), sterol-Co desaturase (SCD). A much more...

The purpose of the study is to identify paired combinations associated with meat productivity in Aberdeen-Angus cattle for genes somatotropin cascade (growth hormone bGH, growth receptor bGHR, insulin-like factor-1 bIGF-1). determination animal genotypes was carried out by PCR-RFLP. Results statistical processing using software capabilities "Microsoft Excel 2010" and "Statistica 6.0". Paired bGHR bIGF-1 revealed marking diplotype polymorphic signs allowing a comprehensive assessment genetic...

Kazakh white-headed and Auliekol breeds are mostly spread through Kazakhstan animals with dual purpose productivity directions including meat milk. native cattle still largely unexplored based on the genetic markers of great interest in country. In this study, we for first time applied high-density SNP genotyping two indigenous to study diversity, population structure relationships different foreign breeds. Using GGP Bovine 150K array principal component analysis (PCA), populations estimates...

The defeat of the central nervous system in influenza reflects properties both pathogen itself and complex pathogenetic mechanisms infectious process. Existing modern theories do not fully explain pathological conditions system, which is still accompanied by ambiguous clinical arguments about direct cytopathic effect virus on neural tissue with development encephalitis. Another rare complication flu acute disseminated encephalomyelitis. autoimmune mechanism this disease universally...

Modern cattle breeding is characterised by the need to select specific animals with extraordinary meat performance, as well an ability adapt natural environment in order develop new, improved breeds. As Auliekol and Kazakh white-head races are especially interesting farmers Kazakhstan, we chose study three polymorphs of somatotropic cascade genes: bPit-1, bGH bGHR whole blood such animals, which known have impact on meatiness good health. The following polymorphic variations were revealed:...

As a result of GWAS performed using single-locus linear model on the basis data obtained GeneSeek GGP Bovine 150 K chip for 790 bulls Kazakh White-headed breed. 81 SNPs associated with average daily gain were established, which 66 are located within 29 protein-coding genes. The biological pathways through candidate genes included in control development sign young stock breed have been characterized. HERC3 gene, 12 identified, is considered and discussed more detail.

Equine 80k HTS («Illumina Inc.», АҚШ) микрочиптерін пайдалану негізінде бір нуклеотидті полиморфизмдердің (SNP) отандық жылқылардың өнімділік қасиеттерімен байланысын толық геномды іздеу және генетикалық әртүрлілігін зерттеу нәтижелері келтірілген. Жылқылардың келесі тұқымдары мен типтері нысаны болып табылды: жабы (n = 631), адай 303) найман 158) типтері, мұғалжар 584), көшім 226) қостанай 116) тұқымдары. SNP-генотиптеудің сапасын бақылау PLINK1.9 бағдарламалық жасақтамасын қолдану арқылы...

Purpose: to analyze and establish distribution patterns of QTL associated SNP across common breedspecific sections the genome Kazakh white-headed Auliekol breeds. Materials methods: breeds were studied. The material for study is samples hair follicles 712 bulls 452 Data on animal genotypes obtained using DNA chip GeneSeek GGP Bovine 150K. Genome-wide association (GWAS): calculating linear regression dependence determination coefficient was performed Plink. GWAS analysis four growth...

The article presents the results of assessing possibilities predicting meat productivity Kazakh white-headed and Auliekol cattle by increasing alleles QTL associated SNP. 4 polymorphic sites were selected for each breeds. Priority in selection targets given to those with a higher frequency occurrence an alternative allele (at least 15%), location different functional regions genome genes, distribution chromosomes, as well belonging known QTL. Analysis genotypes sample showed that...

The article presents the results of a genome-wide search for QTL associated SNP with phenotypic effects in Kazakh white-headed and Auliekol cattle. There were determined 6 genomic regions common two breeds (with total length 192.8 mB bp), 7 breed-specific (total 19.52 12 breed 15, 10 bp). Of 479 breed-wide (161 birth weight, 224 weaning body weight at months, 84 average daily gain), only 44 are genome most similar 1 area breed. A significant part that we established was also described by...