A5033852881- Bone Tissue Engineering Materials
- Nicotinic Acetylcholine Receptors Study
- biodegradable polymer synthesis and properties
- Collagen: Extraction and Characterization
- Ion channel regulation and function
- Receptor Mechanisms and Signaling
- Marine Biology and Environmental Chemistry
- Electrospun Nanofibers in Biomedical Applications
Ludwig-Maximilians-Universität München
2021-2023
SRM Institute of Science and Technology
2017-2019
SRM University
2017
Unlike most neuronal nicotinic acetylcholine receptor (nAChR) subunits, α7, α9, and α10 subunits are able to form functional homo- or heteromeric receptors without any β subunits. While the α7 subtype is widely distributed in mammalian brain several peripheral tissues, α9 α9α10 nAChRs mainly found cochlea immune cells. α-Conotoxins that specifically block showed anti-nociceptive anti-hyperalgesic effects animal models. Hence, this considered a drug target for analgesics. In contrast...
Understanding the determinants of α-conotoxin (α-CTX) selectivity for different nicotinic acetylcholine receptor (nAChR) subtypes is a prerequisite design tool compounds to study nAChRs. However, optimization these small, disulfide-rich peptides difficult not only because an absence α-CTX/nAChR co-structures but also it challenging predict how mutation α-CTX will alter its potency and selectivity. As prototypical system investigate selectivity, we employed LvIA that 25-fold selective α3β2...