A5002332035- Pharmaceutical studies and practices
- Pharmacogenetics and Drug Metabolism
- Antibiotics Pharmacokinetics and Efficacy
- Drug Transport and Resistance Mechanisms
- Diet and metabolism studies
- HIV/AIDS Research and Interventions
- HIV/AIDS drug development and treatment
- Statistical Methods in Clinical Trials
- Computational Drug Discovery Methods
- Dental Anxiety and Anesthesia Techniques
- Pregnancy and Medication Impact
- Metabolism and Genetic Disorders
- Dental Erosion and Treatment
- Pharmacological Effects and Toxicity Studies
- Oral microbiology and periodontitis research
- Pharmaceutical Practices and Patient Outcomes
- Coffee research and impacts
- Climate Change, Adaptation, Migration
- Reproductive tract infections research
- Health Systems, Economic Evaluations, Quality of Life
- Advancements in Transdermal Drug Delivery
- Celiac Disease Research and Management
- Neonatal Health and Biochemistry
- HIV-related health complications and treatments
- Respiratory and Cough-Related Research
Age UK
2023-2025
Simcyp (United Kingdom)
2013-2024
GlaxoSmithKline (United Kingdom)
2022-2024
University of Manchester
2011-2016
Astellas Pharma (Japan)
2016
American Pharmacists Association
2009
The magnitude of any metabolic drug–drug interactions (DDIs) depends on fractional importance inhibited pathway which may not necessarily be the same in young children when compared to adults. ontogeny pattern cytochrome P450 (CYP) enzymes (CYPs 1A2, 2B6, 2C8, 2C9, 2C18/19, 2D6, 2E1, 3A4) and renal function were analyzed systematically. Bootstrap methodology was used account for variability, define age range over statistical differences existed between each pair specific pathways. A number...
The aim of this work was to develop a physiologically based pharmacokinetic (PBPK) model for conversion phosphate prodrugs active drug via intestinal alkaline phosphatase (IAP) implementing generalized modeling strategy. Fostemsavir and fostamatinib were chosen as drugs since there is extensive clinical data following administration oral formulations. LUA scripting used an "in vitro" vivo" extrapolation the rate derived from Caco2 cell lines using absolute IAP abundance approach. Simcyp v23...
Glomerular filtration rate (GFR) is an important measure of renal function. Various models for its maturation have recently been compared; however, these used markers, which are subject to different elimination processes. Inulin clearance data (a purer probe GFR) collected from the literature were determine age-related changes in GFR aspects drug excretion pediatrics. An ontogeny model was derived using a best-fit with various combinations covariates such as postnatal age, gestational age at...
Abstract It is critical to understand the impact of significant physiological changes during pregnancy on extent maternal and fetal drug exposure. Fostemsavir (FTR) a prodrug temsavir (TMR) approved in combination with other antiretrovirals for multi‐drug‐resistant human immunodeficiency virus (HIV) infections. This physiologically based pharmacokinetic model (PBPK) study was used estimate TMR PK pregnant populations each trimester inform FTR dosing. A PBPK developed validated using data...
Many drug–drug interactions (DDIs) in the pediatric population are managed based on data generated adults. However, due to developmental changes elimination pathways from birth adolesence, and variable weight‐adjusted dose of interacting drugs, assumption DDIs being similar adults pediatrics might not be correct. This study compares magnitude reported adult populations. A systematic literature review was undertaken identify reports subjects. total 145 were identified over age range 20 years....
Abstract In celiac disease (CeD), gastrointestinal CYP3A4 abundance and morphology is affected by the severity of disease. Therefore, exposure to substrates extent drug interactions altered. A physiologically‐based pharmacokinetic (PBPK) population for different severities CeD was developed. Gastrointestinal physiology parameters, such as luminal pH, transit times, morphology, P‐gp, expression were included in development population. Data on physiological difference between healthy subjects...
Aims The current work describes the development of mechanistic vaginal absorption and metabolism model within Simcyp Simulator to predict systemic concentrations following application ring gel formulations. Methods Vaginal cervix physiology parameters were incorporated in development. study highlights assumptions including simulation results comparing 5 different compounds, namely, dapivirine, tenofovir, lidocaine, ethinylestradiol etonogestrel, administered as or gel. Due lack data,...
Background: Physiologically based pharmacokinetic (PBPK) modeling and simulating may be a powerful tool in predicting drug behaviors specific populations. It is mathematical model that relates the (PK) profile of compound with human anatomical characteristics, physiological biochemical parameters. Predictions using PBPK models offer promising way to guide development can used optimize clinical dosing regimens. However, PK data new drugs pediatric population are too limited therapy, which...
Abstract A new approach for calculation of sample size in pediatric clinical pharmacokinetic studies was suggested based on desired precision a parameter interest. The estimate variability calculations could be obtained from different sources. It is not known whether these sources constantly show higher/lower across compounds and age groups. We estimates clearance, volume distribution area under the plasma concentration‐time curve 5 drugs adult/pediatric classic studies, physiologically...
The research investigates the impact of climate change on migration population in Erbil province, Ashti district as a model, to prove this researchers relied elicitation and analytic method show elements its phenomena, represented by rain temperature, then analyze percentage clear study area at urban rural levels highlighted factors that led region, such lack water resources decrease agricultural production livestock challenging development because change, divides into three sections,...
In vivo derived ontogeny profiles for CYP1A2 and CYP3A4, show improved clearance (CL) predictions within a paediatric physiologically based pharmacokinetic (p-PBPK) model1. The aim of this study is to derive functions (OF) CYP2C9 CYP2C19 on age related CL data ibuprofen pantoprazole & lansoprazole, respectively. A literature review was undertaken collect these probes, the values were deconvoluted back intrinsic (per mg liver microsomal protein) as described previously. 'best-fit'...