A5041317291- Immunotherapy and Immune Responses
- Nuclear physics research studies
- T-cell and B-cell Immunology
- Nuclear Physics and Applications
- Atomic and Molecular Physics
- Immune Cell Function and Interaction
- Integrated Circuits and Semiconductor Failure Analysis
- Astronomical and nuclear sciences
- Semiconductor materials and devices
- VLSI and Analog Circuit Testing
- Neurobiology and Insect Physiology Research
- Superconducting Materials and Applications
- CAR-T cell therapy research
- Dermatology and Skin Diseases
- Advanced Chemical Physics Studies
- Insect Pheromone Research and Control
- Neural dynamics and brain function
- EEG and Brain-Computer Interfaces
- Advanced NMR Techniques and Applications
- Glycosylation and Glycoproteins Research
- RNA Interference and Gene Delivery
- Electronic and Structural Properties of Oxides
- Advanced Memory and Neural Computing
- Invertebrate Immune Response Mechanisms
- Skin Protection and Aging
Kyushu University
2013-2024
Osaka University
2010-2013
Tokyo Institute of Technology
2010
Kyushu Institute of Technology
2008-2010
The University of Texas Southwestern Medical Center
1988-2008
Toshiba (Japan)
2004
Southwestern Medical Center
1996
Johannes Gutenberg University Mainz
1995
Kyoto University
1991-1993
The β-decay half-lives of 38 neutron-rich isotopes from (36)Kr to (43)Tc have been measured; the (100)Kr, (103-105)Sr, (106-108)Y, (108-110)Zr, (111,112)Nb, (112-115)Mo, and (116,117)Tc are reported here. results when compared with previous standard models indicate an overestimation in predicted by a factor 2 or more A≈110 region. A revised model based on second generation gross theory β decay better predicts measured suggests rapid flow neutron-capture process (r-matter flow) through this...
Abstract Dendritic cells are specialized APCs that exhibit an extraordinary capacity to activate naive T cells. Langerhans (LC), as epithelial tissue-specific members of this family, play key roles in the induction cell-mediated immunity against environmental, infectious, and tumor-associated Ags skin. A major limitation studying biology dendritic or LC has been absence stable, long-term cell lines. To overcome limitation, we have established a series APC lines (XS series) from newborn...
Dendritic epidermal T cells (DETC) are CD3+, CD45+, CD4-, CD8-, TCR-V gamma 3/V delta 1+ lymphocytes that reside in symbiosis with keratinocytes mouse epidermis. To address mechanisms by which these survive and proliferate within the environment, we have tested hypothesis cytokines secreted neighboring play relevant roles. The present study was conducted to determine whether produce biologically amounts of IL-7, and, if so, its effects on DETC. long term cultured DETC line, 7-17, freshly...
Ultraviolet B (UVB) radiation is a potent modulator of skin-related immune responses, particularly those involving the synthesis and secretion cytokines. The discovery new T cell mitogen, IL-15, prompted use to investigate its expression in skin examine effects UVB on such expression. RNA from unirradiated UVB-irradiated epidermal dermal sheets derived human foreskin as well populations were assayed for IL-15 by semiquantitative RT-PCR. Constitutive levels mRNA detected sheets, but not...
Working with the murine epidermal-derived dendritic cell (DC) line XS52, we have observed previously that antigen-specific interaction T cells stimulates their "terminal maturation" into fully professional DC. In this study examined impact of dexamethasone (DEX) on cell-induced event. When added to cocultures XS52 DC and KLH-specific Th1 clone HDK-1 in presence antigen, DEX at relatively low concentrations (10(-9)-10(-7) M) prevented substantially or completely each changes typify terminal...
The folate receptor mediates the uptake of 5-methyltetrahydrofolate in certain cultured cells by a process called potocytosis. When these are grown physiological concentrations folate, increases efficiency vitamin 30-fold. We now show that PAM 212 cells, mouse keratinocyte cell line, unable to grow 1 nM unless they express functional receptor. These results suggest under conditions, tissue body may depend on obtain enough for growth.
The low-lying states in ¹⁰⁶Zr and ¹⁰⁸Zr have been investigated by means of β-γ isomer spectroscopy at the radioactive isotope beam factory (RIBF), respectively. A new with a half-life 620 ± 150 ns has identified ¹⁰⁸Zr. For sequence even-even Zr isotopes, excitation energies first 2⁺ reach minimum N = 64 gradually increase as neutron number increases up to 68, suggesting deformed subshell closure 64. ground state indicates that spherical gap predicted 70 is not large enough change shape....
Abstract Langerhans cells (LC) are skin-specific members of the dendritic cell (DC) family. DC unique among APC for their capacity to activate immunologically naive T cells, but little is known about chemotactic recruitment cells. We now report that LC produce macrophage inflammatory protein-1 gamma (MIP-1 gamma), a newly identified CC chemokine. MIP-1 mRNA was detected in epidermal freshly procured from BALB/c mice, and depletion I-A+ (i.e., LC) abrogated expression. XS52 LC-like line as...
The effects of the nitrogen in HfSiON gate dielectric on electrical and thermal properties were investigated. It is clearly demonstrated that enhances constant silicates. High constants are maintained boron penetration substantially suppressed during high temperature annealing. These ascribed to homogeneity bond structure film containing through
Abstract Dendritic cells (DC) are a specific subset of APC characterized by the potent ability to activate immunologically naive T cells. We have observed previously that murine epidermis-derived DC line XS52 undergoes set profound changes upon Ag-specific interaction with cells, including IL-1 beta secretion acquired expression CD86, and lost CD115 (CSF-1 receptor) proliferative responsiveness CSF-1. These changes, which appear reflect critical transition during Ag presentation, been termed...
Abstract IL-7 plays a central role in regulating the growth and differentiation of T cells. We have reported previously that epidermal keratinocytes produce biologically relevant amounts IL-7, thereby supporting gamma delta In this report, we report gene expression is regulated by IFN-gamma. Treatment Pam 212 with IFN-gamma induced preferential 2.6- 1.5-kb mRNAs, addition to 2.9- 1.7-kb mRNAs are expressed constitutively. The produced through use alternative transcription initiation sites;...
We have established recently from mouse epidermis long-term dendritic cell lines (XS series) that resemble epidermal Langerhans cells (LC) by their surface phenotype, Ag-presenting profile and cytokine mRNA profile. The growth of XS was promoted maximally granulocyte-macrophage-CSF or a factor secreted NS lines, which are fibroblastic dispase-separated specimens epidermis. purpose this study to determine the identity cells. report following: 1) express constitutively for CSF-1; 2) CSF-1R at...
Capture-safety, defined as the avoidance of any timing error due to unduly high launch switching activity in capture mode during at-speed scan testing, is critical for avoiding test- induced yield loss. Although point techniques are available reducing IR-drop, there a lack complete capture-safe test generation flows. The paper addresses this problem by proposing novel and practical scheme, featuring (1) reliable capture-safety checking (2) effective improvement combining X-bit identification...
Ultraviolet B irradiation of skin leads to immunologic tolerance, rather than immunity against newly introduced Ag, by altering the function Langerhans cells, skin-specific members dendritic cell (DC) family. Using murine epidermal-derived DC line, XS52, which retains important features resident we have tested hypothesis that UV radiation delivers a signal leading apoptosis. XS52 when exposed modest fluences (25-100 J/m2) radiation, underwent apoptosis during subsequent 6-h incubation with...
IL-1 beta has been reported to play an essential role in the induction of T cell-mediated immune responses skin, and Langerhans cells are considered be primary source epidermis. We have established recently a long-term dendritic cell line (XS52) from mouse This resembles resident epidermal many respects, including potent capacity present protein Ag (KLH) CD4+ Th1 clone (HDK-1) expression mRNA. sought determine whether XS52 secrete upon Ag-dependent interaction with and, if so, elucidate...
The population of the high-spin isomers in ${}^{139}$Nd and ${}^{140}$Nd was investigated using ${}^{96}$Zr(${}^{48}$Ca,$xn$) reaction JUROGAM + RITU GREAT setup employing recoil decay tagging technique. Three transitions feeding 23/2${}^{+}$ isomer two 20${}^{+}$ were identified. newly observed allowed excitation energy to be established assign configurations states bands deexcited by both nuclei.
Telomeres shorten with successive cell divisions in normal somatic cells, while telomerase plays an important role maintaining their lengths. Although activity was originally described as being expressed exclusively by immortal cells and germline a recently developed PCR-based technique (telomeric repeat amplification protocol (TRAP)) has revealed that peripheral blood leukocytes also exhibit this following mitogenic stimulation. In study, we examined mechanisms which stimuli up-regulated T...
Murine epidermis contains two leukocyte populations: Langerhans cells (LC), which are APC of dendritic cell (DC) lineage, and epidermal T (DETC), members the tissue-type gamma delta family. Despite close physical approximation in vivo, extent to LC DETC affect each other's function has remained unknown. We addressed this question using long term DC line XS52 7-17, both were established from mouse epidermis, retain important features resident populations they derived. proliferated maximally...
As the first step of systematic studies on neutron-rich Mg isotopes, structure ${}^{28}$Mg has been investigated by $\ensuremath{\beta}$-decay spectroscopy spin-polarized ${}^{28}$Na at TRIUMF. Spin-parity assignments have successfully performed for levels in taking advantage anisotropic $\ensuremath{\beta}$ decay. Previous three were reconfirmed. New four including a newly found 2${}^{+}$ level 7.461 MeV. The experimental results compared, level-by-level basis, with shell-model calculation...
We have reported previously that XS52 cells, a long-term dendritic cell (DC) line established from mouse epidermis, proliferate maximally in response to CSF-1, and cells expanded this manner induce brisk proliferation of HDK-1 T (KLH-specific Th1 clone) 5S8 (DNBS-specific Th0 the presence Ag. Our purpose was determine whether CSF-1-dependent mitotic potential might be affected upon Ag-dependent interaction with these clones. Both surface CSF-1R expression responsiveness CSF-1 became...