A5103138290- Genetics and Neurodevelopmental Disorders
- CRISPR and Genetic Engineering
- Genomic variations and chromosomal abnormalities
DKFZ-ZMBH Alliance
2023
German Cancer Research Center
2023
Heidelberg University
2023
Abstract MYT1L is an autism spectrum disorder (ASD)-associated transcription factor that expressed in virtually all neurons throughout life. How mutations cause neurological phenotypes and whether they can be targeted remains enigmatic. Here, we examine the effects of deficiency human mice. Mutant mice exhibit neurodevelopmental delays with thinner cortices, behavioural phenotypes, gene expression changes resemble those ASD patients. target genes, including WNT NOTCH , are activated upon...