A5102810474- Data Management and Algorithms
- Caching and Content Delivery
- Mobile Ad Hoc Networks
- Opportunistic and Delay-Tolerant Networks
- Energy Efficient Wireless Sensor Networks
- Peer-to-Peer Network Technologies
- Context-Aware Activity Recognition Systems
- Advanced Database Systems and Queries
- Privacy-Preserving Technologies in Data
- Mitochondrial Function and Pathology
- Optimization and Search Problems
- Genetic and Kidney Cyst Diseases
- Mobile Agent-Based Network Management
- RNA and protein synthesis mechanisms
- Vehicular Ad Hoc Networks (VANETs)
- Distributed systems and fault tolerance
- Cryptography and Data Security
- Mycobacterium research and diagnosis
- Advanced Breast Cancer Therapies
- Indoor and Outdoor Localization Technologies
- Microtubule and mitosis dynamics
- Algorithms and Data Compression
- ATP Synthase and ATPases Research
- Tuberculosis Research and Epidemiology
- Epigenetics and DNA Methylation
Terry Fox Research Institute
2021-2024
Simon Fraser University
2016-2021
Wonkwang University
2010-2021
University of British Columbia
2021
Seoul National University
2012-2015
Korea University
2004-2012
Pusan National University
2010
CJ CheilJedang (South Korea)
2010
Convergence
2007
Sungkyunkwan University
2007
Cilia have a unique diffusion barrier (“gate”) within their proximal region, termed transition zone (TZ), that compartmentalises signalling proteins the organelle. The TZ is known to harbour two functional modules/complexes (Meckel syndrome [MKS] and Nephronophthisis [NPHP]) defined by genetic interaction, interdependent protein localisation (hierarchy), proteomic studies. However, composition molecular organisation of these modules links human ciliary disease are not completely understood....
Various kinases, including a cyclin-dependent kinase (CDK) family member, regulate the growth and functions of primary cilia, which perform essential roles in signaling development. Neurological disorders linked to CDK-Like (CDKL) proteins suggest that these underexplored kinases may have similar functions. Here, we present crystal structures human CDKL1, CDKL2, CDKL3, CDKL5, revealing their evolutionary divergence from CDK mitogen-activated protein (MAPKs), an unusual ?J helix important for...
Wi-Fi received signal strength (RSS) fingerprint-based indoor positioning has been widely used because of its low cost and universality advantages. However, the RSS is greatly affected by multipath interference in environments, which can cause significant errors observations. Many methods have proposed to overcome this issue, including average method error handling method, but these existing do not consider ever-changing dynamics environments. In addition, traditional RSS-based clustering...
The DosS (DevS) and DosT histidine kinases form a two-component system together with the DosR (DevR) response regulator in Mycobacterium tuberculosis. DosT, which have high sequence similarity to each other over length of their amino acid sequences, contain two GAF domains (GAF-A GAF-B) N-terminal sensory domains. Complementation tests conjunction phylogenetic analysis showed that DevS smegmatis is more closely related than DosS. We also demonstrated vivo M. tuberculosis play differential...
Resistance to sodium carbonate extraction is regarded as a canonical way distinguish integral membrane proteins (MPs) from other membrane-associated proteins. However, it has been observed that releases some mitochondrial MPs. Here, by analyzing both artificially designed and native inner MPs containing transmembrane domains (TMDs) of different hydrophobicities, we show treatment can release moderately hydrophobic TMDs the membrane. These results suggest resistance sensitivity may be...
Abstract The development of large‐scale wireless sensor networks engenders many challenging problems. Examples such problems include how to dynamically organize the nodes into clusters and compress route sensing information a remote base station. Sensed data in systems reflect spatial temporal correlations physical attributes existing intrinsically environment. Noteworthy efficient clustering schemes compressing techniques proposed recently leverage spatiotemporal correlation. These...
Mitochondrial inner membrane proteins that carry an N-terminal presequence are sorted by one of two pathways: stop transfer or conservative sorting. However, the sorting pathway is known for only a small number proteins, in part due to lack robust experimental tools with which study. Here we present approach facilitates determination protein pathways vivo fusing mitochondrial C-terminal Mgm1p containing rhomboid cleavage region. We validated Mgm1 fusion using set known, and determined mode...
Abstract Hepatocyte nuclear factor 4A (HNF4A/NR2a1), a transcriptional regulator of hepatocyte identity, controls genes that are crucial for liver functions, primarily through binding to enhancers. In mammalian cells, active and primed enhancers marked by monomethylation histone 3 (H3) at lysine 4 (K4) (H3K4me1) in cell type-specific manner. How this modification is established maintained connection with transcription factors (TFs) remains unknown. Using analysis genome-wide modifications,...
To protect users’ private locations in location-based services, various location anonymization techniques have been proposed. The most commonly used technique is spatial cloaking, which organizes exact into cloaked regions (CRs). This satisfies the K-anonymity requirement; that is, querier not distinguishable among K users within CR. However, practicality of cloaking limited due to lack privacy-preserving query processing capacity, for example, providing answers user's queries based on...
Sensor nodes transmit the sensed information to sink through wireless sensor networks (WSNs). They have limited power, computational capacities and memory. Portable devices are increasing in popularity. Mechanisms that allow be efficiently obtained mobile WSNs of significant interest. However, a introduces many challenges data dissemination large WSNs. For example, it is important identify locations sinks disseminate from multi-source multi-mobile sinks. In particular, stationary path may no...
A fundamental problem for peer-to-peer (P2P) applications in mobile-pervasive computing environment is to efficiently identify the node that stores particular data items and download them while preserving battery power. In this paper, we propose a P2P Minimum Boundary Rectangle (PMBR, short) which new spatial index specifically designed mobile environments. contains desirable item (s) can be easily identified by reading PMBR index. Then, selective tuning algorithm, called Distributed...
Indexing provides for selective tuning but suffers from the drawback that, in order to conserve battery power, client has wait and tune index segment. In location-aware mobile services (LAMSs), it is important reduce query response time since a late may contain out-of-date information. this paper, we present broadcast-based spatial processing scheme designed support nearest neighbor (NN) processing. With proposed schemes, broadcast data items are sorted sequentially based on their locations...
Neurons throughout the mammalian brain possess non-motile cilia, organelles with varied functions in sensory physiology and cellular signaling. Yet, roles of cilia these neurons are poorly understood. To shed light into their functions, we studied EFHC1, an evolutionarily conserved protein required for motile function linked to a common form inherited epilepsy humans, juvenile myoclonic (JME). We demonstrate that C. elegans EFHC-1 within specialized mechanosensory where it regulates neuronal...
<mml:math xmlns:mml="http://www.w3.org/1998/Math/MathML" id="M1"><mml:mrow><mml:mi>K</mml:mi></mml:mrow></mml:math>-anonymization generated a cloaked region (CR) that was id="M2"><mml:mrow><mml:mi>K</mml:mi></mml:mrow></mml:math>-anonymous; is, the query issuer indistinguishable from id="M3"><mml:mi>K</mml:mi><mml:mo>-</mml:mo><mml:mn fontstyle="italic">1</mml:mn></mml:math> other users (nearest neighbors) within CR. This reduced probability of issuer’s location being exposed to untrusted...
The sorting of an individual transmembrane (TM) segment multi‐spanning membrane proteins by the TIM23 complex in mitochondrial inner is poorly understood. Using Mgm1 fusion approach, we attempted to assess insertion TM segments Mdl1p and Mdl2p, ABC transporters. Although these transporters share high sequence similarity, our results show that their patterns differ specific residues domains strongly influence or translocation. These data imply TIM23‐mediated highly depends on domain context.
Summary To receive location‐based services (LBS), users must disclose their locations and queries to the LBS server, which can expose user's identity, location, other information. Recently, techniques for protecting user privacy using dummies have been researched. However, many factors, such as distance between obstacles dummies, be considered in order create dummies. Therefore, this study proposes an efficient dummy creation technique improve protection. Experimental results show that...
Various studies related to spatial indices are currently being conducted. Most of these focus on lowering the costs for indexed searches in on-demand environments during query processing. However, often have issues with service delays when there is a congestion server dealing information about complicated moving objects. Therefore, study that considers broadcast environment required. Studies transfer should consider characteristics one-dimensional sequential flow. thus far indexing methods...