A5031460072- Computational Drug Discovery Methods
- GABA and Rice Research
- Natural Antidiabetic Agents Studies
- Cannabis and Cannabinoid Research
- Medicinal Plants and Neuroprotection
- Cholinesterase and Neurodegenerative Diseases
- Gout, Hyperuricemia, Uric Acid
- Natural product bioactivities and synthesis
- Pharmacological Effects of Natural Compounds
Adekunle Ajasin University
2018-2019
Available antimalarial drugs have been associated with numerous side effects, which include skin rashes and myelo-suppression. Therefore, it is of interest to explore compounds from natural source having drug-like properties without effect. This study focuses on the screening
Introduction: Gout is a type of painful inflammation initiated by the interactions between monosodium urate crystals and connective tissue. Xanthine oxidase (XO) catalyzes oxidation hypoxanthine to xanthine, then uric acid. The primary treatments for gout include XO inhibitors. At present, allopurinol most used inhibitor treatment gout. However, it can cause adverse effects commonly known as hypersensitivity syndrome, thereby limiting its usage. Consequently, necessary develop potent less...
Abstract The ionotropic activation of N-methyl-D-aspartic acid (NMDA) plays a significant role in different type neurodegenerative disease, as it is tetramer with two Glycine binding subunit and glutamate subunits. NMDA receptor can be inhibited by either blocking the glycine site or site. Previously reported inhibitors focus on inhibition subunit, which was to associated side effects such ataxia, memory deficits, neurotoxicity. Therefore, compounds antagonistic effect are been explored...