A5025841942- biodegradable polymer synthesis and properties
- Carbon dioxide utilization in catalysis
- Polyoxometalates: Synthesis and Applications
- Organometallic Complex Synthesis and Catalysis
- Blood Pressure and Hypertension Studies
- Copper-based nanomaterials and applications
- Transition Metal Oxide Nanomaterials
- Pharmaceutical Practices and Patient Outcomes
- Advanced battery technologies research
- Analytical Methods in Pharmaceuticals
Tianshui Normal University
2025
State Key Laboratory of Applied Organic Chemistry
2018-2021
Lanzhou University
2018-2021
Lanzhou City University
2019
China Nonferrous Metal Mining (China)
2019
Fu Wai Hospital
2011
Chinese Academy of Medical Sciences & Peking Union Medical College
2011
Synthesizing different types of sequence-controlled copolyesters can enrich the diversity and modify their properties more precisely, but it is still a challenge to synthesize complicated copolyester using hydroxy acids in living polymerization manner. In this work, highly regioselective stereoselective catalytic system was developed biorenewable biodegradable mandelic acid lactic with isotactic-alternating, heterotactic-alternating, ABAA-type precise sequences. Because regular incorporation...
A novel two-dimensional (2D) amorphous VOPO4/graphene (A-VOP/G) heterostructure, which features rapid ion diffusion pathways, numerous active sites, high conductivity, and superior stability, serves as a high-voltage cathode for zinc-ion batteries (ZIBs). The A-VOP/G achieves platform (1.50 V) is stable over 2000 cycles at 5 g-1.
Three potassium crown ether complexes supported with bulky amidinate ligands were synthesized for the ring-opening polymerization (ROP) of rac-lactide. The side reaction initiated directly by ligand anion was suppressed well in presence alcohol as our design, and synthesis linear polylactide a molecular weight high 117.7 kg/mol successful together an isoselectivity value Pm = 0.88 at −70 °C. In this system, lactide can be deprotonated to give enolate, which initiate ROP absence alcohol;...
Ring-opening polymerization (ROP) of rac-O-carboxyanhydride mandelic acid (rac-manOCA) is a promising method to synthesize isotactic biodegradable polyester poly(mandelic acid), which has high glass-transition temperature (Tg) and melting (Tm) due the formation stereocomplex. However, it still big challenge poly(rac-manOCA) so far because easy epimerization manOCA in progress. In this work, highly isoselective ROP rac-manOCA system as first stereoselective example reported using weak Lewis...
A series of mononuclear salen–sodium anions, as the first examples, were synthesized with tetra-alkyl ammonium a counterpart cation. These complexes are efficient catalysts for isoselective ring-opening polymerization rac-lactide; molecular weights polymers under control and weight distributions narrow when five equivalents BnOH is used an initiator. The best isoselectivity value Pm = 0.82 was achieved at −70 °C. experimental results together density functional theory calculation show that...
To control the monomer sequence in copolymers of different hydroxyl acids remains a big challenge so far, which is valuable for tuning properties copolyesters. In this work, perfectly alternating sequence-controlled copolymer mandelic acid and glycolic acid, as first example, was synthesized via highly regioselective ring-opening polymerization (ROP) cyclic diester (3-phenyl-1, 4-dioxane 2, 5-diketone, PDD). The high molecular weight poly(mandelate-alt-glycolate) (66.8 kg/mol) achieved too,...
The stereoselective ring-opening polymerization (ROP) of O-carboxyanhydrides (OCAs) remains a major challenge due to the easy epimerization monomers. In this work, using zinc alkoxide initiator, highly efficient ROP enantiopure 5-methyl-1,3-dioxolane-2,4-dione (LacOCA), 5-benzyl-1,3-dioxolane-2,4-dione (PheOCA), and 5-(4-(benzyloxy)benzyl)-1,3-dioxolane-2,4-dione (Try(Bn)OCA) was achieved without obvious epimerization. Moreover, isoselective rac-LacOCA, rac-PheOCA, rac-Try(Bn)OCA successful...
Monomer sequence controllable syntheses of copolymers, including copolyesters, remain a challenge in polymer science. Although alternating sequence-controlled copolymerization O-carboxyanhydrides (OCAs) can be achieved via using syndioselective initiators, the lactic acid-derived O-carboxyanhydride (LacOCA) with other monomers still suffers from lack highly initiators. In this work, system for ring-opening polymerization (ROP) LacOCA was bulky amine tris(phenolate) hafnium alkoxide initiator...
The synthesis of highly stereoregular poly(mandelic acid) (PMA) via controllable polymerization is a considerable challenge because the easy racemization monomers during polymerization; consequently, precise stereoblock copolymers PMA have not been reported so far. In this work, was synthesized through living ring-opening O-carboxyanhydrides (OCAs) mandelic acid using active OOO-tridentate bis(phenolate)/zinc catalysts. system, side reaction suppressed very well decreasing basicity ligands...
To compare the pharmacokinetic (PK) profiles and evaluate PK interaction of hydrochlorothiazide (HCTZ) used alone in combination with benazepril (BENA) or valsartan (VAL) healthy Chinese volunteers.Data from two Phase I clinical trials (Study A Study B) were combined analyzed. was an open, randomized, three-period crossover study. Eligible male volunteers randomly assigned to receive a single dose HCTZ (25 mg), BENA (20 mg) HCTZ/BENA (25/20 mg). B open two-period study VAL/HCTZ (160/12.5...