A5072572636- Single-cell and spatial transcriptomics
- Protist diversity and phylogeny
- Coral and Marine Ecosystems Studies
- Marine Invertebrate Physiology and Ecology
- Marine Biology and Environmental Chemistry
- Reproductive biology and impacts on aquatic species
- Retinal Development and Disorders
- Barrier Structure and Function Studies
- Neurobiology and Insect Physiology Research
- Cephalopods and Marine Biology
- 3D Printing in Biomedical Research
- Zebrafish Biomedical Research Applications
- Photoreceptor and optogenetics research
Sorbonne Université
2021-2024
Centre National de la Recherche Scientifique
2021-2024
Laboratoire de Biologie du Développement de Villefranche-sur-Mer
2021-2024
Stazione Zoologica Anton Dohrn
2021
Whole-organism perturbations reveal single-cell responses across the Clytia medusa.
Abstract We present an organism-wide, transcriptomic cell atlas of the hydrozoan medusa Clytia hemisphaerica , and determine how its component types respond to starvation. Utilizing multiplexed scRNA-seq, in which individual animals were indexed pooled from control perturbation conditions into a single sequencing run, we avoid artifacts batch effects are able discern shifts state response organismal perturbations. This work serves as foundation for future studies development, function,...
Photoreceptor cells (PRC) are neurons highly specialized for sensing light stimuli and have considerably diversified during evolution. The genetic mechanisms that underlie photoreceptor differentiation accompanied the progressive increase in complexity diversification of this sensory cell type a matter great interest field. A role homeodomain transcription factor Onecut (Oc) formation is proposed throughout multicellular organisms. However, knowledge identity Oc downstream-acting factors...
Abstract Planktonic larvae of many marine invertebrates settle on a suitable substrate and metamorphose into bottom-dwelling adults. Larval settlement is considerable interest both for ecologists evolutionary biologists, who have proposed that anterior sensory systems selection provided the basis animal brains. Nevertheless cellular molecular regulation larval settlement, including in Cnidaria (corals, jellyfish, sea anemones, hydroids) not well understood. We generated compared (aboral)...