A5103054658- Synthesis and Biological Evaluation
- Catalytic C–H Functionalization Methods
- Eicosanoids and Hypertension Pharmacology
- Synthesis and Catalytic Reactions
- Metabolomics and Mass Spectrometry Studies
- Biochemical effects in animals
- Cannabis and Cannabinoid Research
- Multicomponent Synthesis of Heterocycles
- Molecular Sensors and Ion Detection
- Cholesterol and Lipid Metabolism
- Synthesis of heterocyclic compounds
- Metabolism, Diabetes, and Cancer
- Chemical Synthesis and Analysis
- Pharmacological Receptor Mechanisms and Effects
- Diverse Scientific Research Studies
- Receptor Mechanisms and Signaling
- Protein Kinase Regulation and GTPase Signaling
- Pancreatic function and diabetes
- Lipoproteins and Cardiovascular Health
- Sulfur Compounds in Biology
- Sulfur-Based Synthesis Techniques
- Chemical synthesis and alkaloids
- Axial and Atropisomeric Chirality Synthesis
- Trypanosoma species research and implications
- Asymmetric Hydrogenation and Catalysis
Indian Institute of Chemical Biology
2014-2024
Commonwealth Scientific and Industrial Research Organisation
2024
National Institute on Alcohol Abuse and Alcoholism
2022-2023
National Institutes of Health
2022-2023
Weatherford College
2022
We have designed orally bioavailable, non-brain-penetrant antagonists of the cannabinoid-1 receptor (CB1R) with a built-in biguanide sensor to mimic 5′-adenosine monophosphate kinase (AMPK) activation for treating obesity-associated co-morbidities. A series 3,4-diarylpyrazolines bearing rational pharmacophoric pendants limit brain penetration were synthesized and evaluated in CB1R ligand binding assays recombinant AMPK assays. The compounds displayed high affinity potent antagonist...
SARS-CoV-2, a new coronavirus emerged in 2019, causing global healthcare epidemic. Although variety of drug targets have been identified as potential antiviral therapies, and effective candidate against SARS-CoV-2 remains elusive. One the most promising for combating COVID-19 is Main protease (Mpro, protein responsible viral replication. In this work, an in-house curated library was thoroughly evaluated druggability Mpro. We four ligands (FG, Q5, P5, PJ4) inhibitors based on docking scores,...
A series of heterocyclic C5-curcuminoids (bis(arylmethylidene)acetones) (PJ1-PJ6) having a large Stokes shift (Δλ = 104-173 nm) have been synthesized for the selective detection cysteine (Cys), homocysteine (Hcy) and glutathione (GSH) in living cells. The compounds were using new methodology via deacetylation under microwave conditions. photophysical properties these studied. Prominent colour changes from bright yellow to colourless presence thiols observed PJ1. Live cell imaging has...
A number of axially chiral 3-indolyl furanoids have been synthesized and the individual enantiomers are found to be configurationally stable isolable at room temperature.
A new synthetic strategy for the construction of C2‐quaternary indole formation Indolin‐3‐ones has been explored via indium(III) trifluoromethansulphonate catalyst at room temperature with TBHP as a green oxidant in water. This approach oxidative dearomatization process allows to produce natural product Halichrome and broad range C2‐arylated under milder condition very good yields. The self‐dimerization self‐trimerization various derivatives have also achieved same conditions.
We report the development of a one-pot Bunte's reaction-enabled expeditious platform under aqueous conditions for scalable conversion sulfonylureas to synthetically versatile thio-sulfonylureas. The reaction was further propagated in same pot yield diverse chiral and achiral isothiosulfonyl analogs. protocol enabled synthesis various drug-like molecules applied an enantiomeric cannabinoid receptor antagonist SLV326.
Abstract An enantioselective version of the presented functionalization 2‐methyl and 2‐ethyl quinolines as well 2‐methylpyridine with enediones eneamides is currently in progress.