A5091287858- RNA and protein synthesis mechanisms
- Protist diversity and phylogeny
- CRISPR and Genetic Engineering
- Chromosomal and Genetic Variations
- Photosynthetic Processes and Mechanisms
- Microbial Community Ecology and Physiology
- Genomics and Chromatin Dynamics
- Algal biology and biofuel production
- Herpesvirus Infections and Treatments
- Cancer-related molecular mechanisms research
- MicroRNA in disease regulation
- Diatoms and Algae Research
- Insect Resistance and Genetics
- Viral Infections and Immunology Research
- Genomics and Phylogenetic Studies
- Toxin Mechanisms and Immunotoxins
- Insect Pest Control Strategies
- Virus-based gene therapy research
- Circular RNAs in diseases
- Insect Utilization and Effects
University of Ostrava
2017-2022
Vejle Sygehus
2020
Aarhus University
2014-2016
Ohio University
1982
Northeast Ohio Medical University
1982
Abstract Circular RNAs (circRNAs) have recently gained substantial attention in the cancer research field where most, including putative oncogene ciRS-7 (CDR1as), been proposed to function as competitive endogenous (ceRNAs) by sponging specific microRNAs. Here, we report first spatially resolved cellular expression patterns of colon and show that is completely absent cells, but highly expressed stromal cells within tumor microenvironment. Additionally, our data suggest this generally apply...
Unlike amantadine (1-adamantanamine), tromantadine (N-1-adamantyl-N-[2-(dimethyl amino)ethoxy]acetamide hydrochloride) inhibits herpes simplex virus type 1 (KOS strain)-induced cytopathic effect and replication with limited toxicity to the cells. Vero HEp-2 cells tolerated up 2 mg of per X 10(6) for 24-, 48-, or 96-h incubation periods little change in cell morphology. Treatment 10 50 micrograms reduced virus-induced effect. 100 500 inhibited production. Complete inhibition production was...
Departures from the standard genetic code in eukaryotic nuclear genomes are known for only a handful of lineages and few variants seem to exist outside ciliates, most creative group this regard. Most frequent modifications entail reassignment UAG UAA codons, with evidence at least 13 independent cases coordinated change meaning both codons. However, no affecting each two codons separately has been documented, suggesting existence underlying evolutionary or mechanistic constraints. Here, we...
Abstract Background The plastid genomes of the green algal order Chlamydomonadales tend to expand their non-coding regions, but this phenomenon is poorly understood. Here we shed new light on organellar genome evolution in by studying a previously unknown non-photosynthetic lineage. We established cultures two Polytoma -like flagellates, defined basic characteristics and phylogenetic position, obtained complete sequences transcriptome assembly for one them. Results discovered novel deeply...
Insertional mutagenesis screens of retrovirus-induced mouse tumors have proven valuable in human cancer research and for understanding adverse effects retroviral-based gene therapies. In previous studies, the assignment genes to individual retroviral integration sites has been based on close proximity expression patterns annotated at target positions genome. We here employed next-generation RNA sequencing map retroviral-mouse chimeric junctions genome-wide, identify local transcription...
Evidence suggests that some human endogenous retroviruses and retrovirus-like repeats (here collectively ERVs) regulate the expression of neighboring genes in normal disease states; e.g. globin locus is regulated by an ERV9 coordinates long-range gene switching during hematopoiesis activates also intergenic transcripts. While complex transcription regulation associated with integration certain exogenous retroviruses, comparable sustained ERVs less understood.We analyzed ERV using consensus...
Abstract Background The plastid genomes of the green algal order Chlamydomonadales tend to expand their non-coding regions, but this phenomenon is poorly understood. Here we shed new light on organellar genome evolution in by studying a previously unknown non-photosynthetic lineage. We established cultures two Polytoma -like flagellates, defined basic characteristics and phylogenetic position, obtained complete sequences transcriptome assembly for one them. Results discovered novel deeply...