A5030248116- Telomeres, Telomerase, and Senescence
- Antibiotic Resistance in Bacteria
- Genomics and Chromatin Dynamics
- Protein Structure and Dynamics
- DNA Repair Mechanisms
- Alzheimer's disease research and treatments
- DNA and Nucleic Acid Chemistry
- Diverse Scientific Research Studies
- HIV/AIDS drug development and treatment
- Clostridium difficile and Clostridium perfringens research
- Plant nutrient uptake and metabolism
- ZnO doping and properties
- Facial Trauma and Fracture Management
- Chalcogenide Semiconductor Thin Films
- Photodynamic Therapy Research Studies
- CRISPR and Genetic Engineering
- HIV Research and Treatment
- IoT and Edge/Fog Computing
- Enzyme Structure and Function
- Cloud Data Security Solutions
- Dental Radiography and Imaging
- Emotional Intelligence and Performance
- Porphyrin and Phthalocyanine Chemistry
- Plant Stress Responses and Tolerance
- Nanoplatforms for cancer theranostics
MRC Laboratory of Molecular Biology
2021-2023
Nanyang Technological University
2016-2022
McMaster University
2013-2017
University of Engineering and Technology Taxila
2013-2014
National University of Sciences and Technology
2014
Abstract The delivery of therapeutic compounds to target tissues is a central challenge in treating disease. Externally controlled drug release systems hold potential selectively enhance localized delivery. Here we describe liposomes doped with porphyrin–phospholipid that are permeabilized directly by near-infrared light. Molecular dynamics simulations identified novel light-absorbing monomer esterified from clinically approved components predicted and experimentally demonstrated give rise...
HIV immature lattice stability affects capsid maturation by altering IP 6 packaging.
Transcriptional silencing through the Polycomb machinery utilizes a "read-write" mechanism involving histone tail modifications. However, nucleation of and long-term stable transmission silenced state also requires P-olycomb Repressive Complex 2 (PRC2) accessory proteins, whose molecular role is poorly understood. The Arabidopsis VEL proteins are that interact with PRC2 to nucleate propagate at FLOWERING LOCUS C (FLC) locus, enabling early flowering in spring. Here, we report contain domain...
Shelterin and nucleosomes are the key players that organize mammalian chromosome ends into protective telomere caps. However, how they interact with each other at telomeres remains unknown. We report cryo-electron microscopy structures of a human telomeric nucleosome both unbound bound to shelterin factor TRF1. Our reveal TRF1 binds unwrapped nucleosomal DNA by engaging histone octamer. Unexpectedly, binding shifts register 1 bp. discovered phosphorylation C terminus noncanomical surface on...
Acyldepsipeptides (ADEPs) antibiotics bind to Escherichia coli ClpP mimicking the interactions that IGL/F loops in ClpA or ClpX ATPases establish with hydrophobic pockets surrounding axial pore of tetradecamer protease forms. ADEP binding induces opening gates blocking channel and allowing protein substrates be translocated hydrolysed degradation chamber. To identify structural determinants stabilizing open conformation for efficient substrate translocation, we constructed variants amino...
Telomeres are protein-DNA complexes that protect the ends of linear eukaryotic chromosomes. Mammalian telomeric DNA consists 5′-(TTAGGG)n-3′ double-stranded repeats, followed by up to several hundred bases a 3′ single-stranded G-rich overhang. The overhang is bound shelterin component POT1 which interacts with TPP1, involved in telomerase recruitment. A previously published crystal structure N-terminal half high affinity ligand 5′-TTAGGGTTAG-3′ showed first six nucleotides, TTAGGG , OB1...
Telomeres, the ends of linear chromosomes, are composed repetitive DNA sequences, histones and a protein complex called shelterin. How is packaged at telomeres an outstanding question in field with significant implications for human health disease. Here, we studied architecture their spatial association other chromatin domains different cell types using correlative light electron microscopy. To this end, shelterin TRF1 or TRF2 was fused tandem to eGFP peroxidase APEX2, which provided...
Cadmium sulfide ( CdS ) and aluminum-doped zinc oxide Al : ZnO thin films are used as buffer layer front window layer, respectively, in film solar cells. were produced using chemical bath deposition (CBD) sol–gel technique, respectively. For CBD , the effect of composition temperature, dipping time annealing temperature on properties was investigated. The found to be polycrystalline with metastable cubic crystal structure, dense, crack-free surface morphology crystallite size either few...
Availability of internet on different devices like smart phones android based, IOs windows based and PDA etc. has brought into the evolution mobile cloud computing, which is a vast side research nowadays.Internet connectivity become very easy with Wi-Fi, everyone can access using wireless connectivity.A major issue in low level encryption security.This might be security risk for sensitive data available cloud.There are augmented reality systems we want to propose dynamic framework live update cloud.
In Project management, team's motivation is one of the most important factors in success a project.Project Managersmanage whole project by assuring that all members are performing duties they assigned.Emotional Intelligence ability to identify attitude team member towards project.In developing countrieslack emotional intelligence may cost people their jobs.In this paper conflict technical interest development and stress management problems discussed with reference countries an efficient...