A5029765381- Menopause: Health Impacts and Treatments
- Neuroscience and Neuropharmacology Research
- Tryptophan and brain disorders
- Meta-analysis and systematic reviews
- Alzheimer's disease research and treatments
- Estrogen and related hormone effects
- Traumatic Brain Injury Research
- Health Sciences Research and Education
- Memory and Neural Mechanisms
Karolinska Institutet
2020-2024
The brain-specific enzyme CYP46A1 controls cholesterol turnover by converting into 24 S -hydroxycholesterol (24OH). Dysregulation of brain and reduced levels are observed in Alzheimer’s disease (AD). In this study, we report that overexpression aged female mice leads to enhanced estrogen signaling the hippocampus improved cognitive functions. contrast, age-matched overexpressing males show anxiety-like behavior, worsened memory, elevated 5α-dihydrotestosterone hippocampus. We that, neurons,...
Abstract Background Alzheimer’s disease (AD) is characterized by early and progressive synaptic dysfunction loss that are closely related to cognitive impairment in AD patients. Neurogranin (Ng) has emerged as a potential marker of dysfunction, with cerebrospinal fluid (CSF) levels specifically increased AD. In order investigate the translational CSF Ng, present study investigated its alterations relationship AD‐related pathology (Aβ42, tau neurofilament light; NFL) both brain tissue novel...