A5047140822- Nicotinic Acetylcholine Receptors Study
- Memory and Neural Mechanisms
- Neuroscience and Neuropharmacology Research
- Neurotransmitter Receptor Influence on Behavior
- Receptor Mechanisms and Signaling
- Stress Responses and Cortisol
- Smoking Behavior and Cessation
- Neuroendocrine regulation and behavior
- Tryptophan and brain disorders
- Vestibular and auditory disorders
- Neuroscience of respiration and sleep
- Cholinesterase and Neurodegenerative Diseases
- Mitochondrial Function and Pathology
- Epigenetics and DNA Methylation
- Adipose Tissue and Metabolism
- Housing, Finance, and Neoliberalism
- Classical Philosophy and Thought
- Biochemical Analysis and Sensing Techniques
- Health, Environment, Cognitive Aging
- Olfactory and Sensory Function Studies
- Sleep and Wakefulness Research
- Genetics, Aging, and Longevity in Model Organisms
- Genetic Mapping and Diversity in Plants and Animals
- Synthetic Organic Chemistry Methods
- Poetry Analysis and Criticism
Pennsylvania State University
2012-2024
Johns Hopkins University
2022
Virginia Commonwealth University
2022
University of East Anglia
2022
Western Cape Department of Health
2021
King's College London
2018
University of Bristol
2018
Temple University
2008-2017
Cancer Institute (WIA)
2005-2012
Bayer (United States)
2008
The effects of acute nicotine administration (0.09 mg/kg nicotine), chronic (6.3 mg/kg/d for 14 d), and withdrawal from on fear conditioning in C57BL/6 mice were examined. Mice trained using two coterminating conditioned stimulus (30 s; 85 dB white noise)--unconditioned (2 0.57 mA foot shock) pairings tested 24 h later contextual cued conditioning. Acute enhanced conditioning, had no effect impaired Plasma concentrations similar after treatment within the range reported smokers. During...
Nicotine is known to enhance learning and memory in hippocampus-dependent tasks such as contextual fear conditioning. The present study was designed directly examine whether the hippocampus plays a role mediating this enhancement which nicotinic acetylcholine receptor (nAChR) subtypes localized are critical for enhanced learning. Contextual conditioning consisted of two white noise conditioned stimuli presentations, each coterminating with 2 s, 0.57 mA footshock separated by 120 s intertrial...
Growth arrest and DNA damage-inducible β ( Gadd45b ) has been shown to be involved in demethylation may important for cognitive processes. is abnormally expressed subjects with autism psychosis, two disorders associated deficits. Furthermore, several high-throughput screens have identified as a candidate plasticity-related gene. However, direct demonstration of link between memory not established. The current studies first determined whether expression the Gadd45 family genes was affected by...
Abstract One hallmark of adolescent risk‐taking is that it typically occurs when adolescents are with peers. It has been hypothesized the presence peers primes a reward‐sensitive motivational state overwhelms adolescents' immature capacity for inhibitory control. We examined this hypothesis using rodent model. A sample mice were raised in same‐sex triads and tested alcohol consumption either as juveniles or adults, half each age group alone their cagemates. The ‘peers’ increased among mice,...
Memories return to a labile state following their retrieval and must undergo process of reconsolidation be maintained. Thus, disruption cocaine reward memories by interference with may therapeutically beneficial in the treatment addiction.The objectives were elucidate signaling pathway involved memory test whether targeting this could disrupt cocaine-associated contextual memory.Using mouse model conditioned place preference, regulation activity glycogen synthase kinase-3 (GSK3), mammalian...
Histone acetylation is essential for hippocampal memory formation in young adult rodents. Although dysfunctional histone has been associated with age-related decline male rodents, little known about whether altered by aging female In mice, the ability of 17β-estradiol (E 2 ) to enhance object recognition consolidation requires H3 dorsal hippocampus. However, extent which regulated E middle-aged females unknown. The mnemonic benefits appear be greatest middle age, and so pinpointing molecular...