Umesh Kumar

ORCID: 0000-0003-1842-0225
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Research Areas
  • Essential Oils and Antimicrobial Activity
  • Computational Drug Discovery Methods
  • Genetics, Bioinformatics, and Biomedical Research
  • Nanoparticle-Based Drug Delivery
  • Pharmacological Effects of Natural Compounds
  • Nanoparticles: synthesis and applications
  • Proteins in Food Systems
  • Bee Products Chemical Analysis
  • Phytochemicals and Medicinal Plants
  • Microbial Natural Products and Biosynthesis
  • SARS-CoV-2 and COVID-19 Research
  • Insect Pest Control Strategies
  • Fungal Biology and Applications
  • Phytochemistry and Bioactivity Studies
  • Protein Interaction Studies and Fluorescence Analysis
  • Plant Pathogens and Fungal Diseases
  • Enzyme Production and Characterization
  • Gold and Silver Nanoparticles Synthesis and Applications
  • Healthcare and Environmental Waste Management
  • Seed and Plant Biochemistry
  • Food Waste Reduction and Sustainability
  • Natural product bioactivities and synthesis
  • Protein Structure and Dynamics
  • Advanced Drug Delivery Systems
  • Municipal Solid Waste Management

Indira Gandhi Agricultural University
2025

IMS Unison University
2025

Central University of Gujarat
2019-2024

Central University of Haryana
2023-2024

Glocal University
2024

National Botanical Research Institute
2024

Saveetha University
2023

Banaras Hindu University
2022-2023

Institute of Applied Ecology
2021

Indian Institute of Technology Gandhinagar
2019-2021

Modern forestry is gradually moving towards man-made forests on a large scale. Plantations with advanced system have been introduced the goal of sustainable development and to enhance social, ecological, economic benefits. Forest plantations native exotic species established in China worldwide shorter rotation cycles than natural forests. In this paper, we discuss role perspectives plantation Chinese forest development, evolution various programs, ecological effects plantations, measures...

10.3832/ifor3551-014 article EN cc-by-nc iForest - Biogeosciences and Forestry 2021-04-09

Schematic representation of synthesis process Folic Acid (FA) conjugated Bovine Serum Albumin (BSA) nanoparticles for the delivery Fisetin (FST) and its application cancer treatment.

10.1039/d3ra08434e article EN cc-by-nc RSC Advances 2024-01-01

External stimuli responsive dual drugs carrier was synthesized with Au nanorods (NRs) as the platform. On NRs, single stranded DNAs were assembled using 5′ thiol end. Following this, complementary DNA (cDNA) strands hybridized. This hybridized double facilitated doxorubicin (Dox) intercalation into duplexes. The cDNA designed amine functional group assisted to tether platinum [Pt(IV)] prodrugs by establishing amide bond acid at axial ligand. other in Pt(IV) conjugated folic (FA) target...

10.1021/am5000905 article EN ACS Applied Materials & Interfaces 2014-02-22

The use of nanoparticles for cellular therapeutic or sensing applications requires to bind, adhere, the cell surface. While nanoparticle parameters such as size, shape, charge, and composition are important factors in binding, itself must also be considered. All cells have an electrical potential across plasma membrane driven by ion gradient. Under standard conditions gradient will result a -10 -100 mV with net negative charge on cytosolic face. Using combination flow cytometry fluorescence...

10.1039/c3nr01667f article EN Nanoscale 2013-01-01

Nanoparticles used in biological applications encounter a complex mixture of extracellular proteins. Adsorption these proteins on the nanoparticle surface results formation "protein corona," which can dominate interaction with cellular environment. The goal this research was to determine how composition and modification affect binding protein-nanoparticle complexes. We examined collection commonly anionic nanoparticles: quantum dots, colloidal gold nanoparticles, low-density lipoprotein...

10.1039/c3bm60121h article EN Biomaterials Science 2013-01-01

Background Coronary bypass graft failure as a result of acute thrombosis and intimal hyperplasia has been the major challenge in surgical procedures involving small-diameter vascular prosthesis. Coating synthetic grafts with patients' own endothelial cells suggested to improve patency rate overall success surgeries. Methodology/Principal Findings We isolated progenitor (EPCs) from leftover pieces human saphenous vein/mammary artery. demonstrate that EPCs can be expanded generate millions...

10.1371/journal.pone.0007718 article EN cc-by PLoS ONE 2009-11-04

Co3O4, which crystallizes in the spinel phase at temperatures much higher than ambient temperatures, orders antiferromagnetically below its Neel temperature (∼40 K). However, nanosize, it shows ferromagnetic ordering due to surface canting, disorder, imperfect oxygen atom coordination, etc. Here, for first time, we report synthesis of single-crystalline, Co3O4 nanoparticles functionalized with proteins (size 5–7 nm) using cobalt acetate as precursor room aqueous medium by a metal-tolerant...

10.1021/cm702727x article EN Chemistry of Materials 2008-01-31

Cordycepin gets rapidly metabolized in the body into inactive form due to its structural similarity adenosine, thus inhibiting development as a medicinal agent. This study was aimed improve solubility and stability of cordycepin, potential drug with known antiproliferative activity, by encapsulating it bovine serum albumin: β-cyclodextrin nanoparticles. Cordycepin-loaded nanoparticles (CLNPs) were synthesized using antisolvent method characterized thoroughly various techniques. Our dynamic...

10.1021/acs.jafc.3c03608 article EN Journal of Agricultural and Food Chemistry 2023-08-01

A comprehensive understanding of crop responses to diverse environments is essential for designing efficient breeding programs. Currently, such insights are lacking large-seeded lentils under Indian climatic conditions. Given that, this study aimed assess the impacts conditions on phenological developments and yield lentils. This also determine genotype-by-environment interaction (GEI), identify mega-environments, ideal testing locations enhance efficiency national For this, sets lentil...

10.1016/j.heliyon.2025.e42184 article EN cc-by-nc-nd Heliyon 2025-01-23

The fate of bioactivity biomolecules such as enzymes, proteins, and even drug molecules is greatly affected by the conformational changes in proximity solid surfaces. This interaction key to potential their further applications biosensors, delivery, etc. With increasing interest biofunctionalization noble metal nanoparticles for various applications, it important precisely investigate functional groups responsible binding with nanoparticle surfaces probable structural structure both are...

10.1021/jp905806t article EN The Journal of Physical Chemistry C 2009-12-03

Our work investigates the interaction of synthesized graphene with SARS-CoV-2 virus using molecular docking and dynamics (MD) simulation method. The layer dependent inhibitory effect nanosheets on spike receptor-binding domain 6LZG, complexed host receptor i.e. angiotensin-converting enzyme 2 (ACE2) was investigated through computational study. Graphene sample mechanical exfoliation shear stress its mechanism inhibition towards explored by thermodynamics study for free binding energy...

10.1080/07391102.2020.1817788 article EN Journal of Biomolecular Structure and Dynamics 2020-09-11

We investigate the binding interactions of synthesized multi-walled carbon nanotubes (MWCNTs) with SARS-CoV-2 virus. Two essential components structure

10.1039/d0ra08888a article EN cc-by RSC Advances 2021-01-01

Fucoxanthin is a hydrophobic carotenoid with many beneficial biological activities. However, due to low aqueous solubility their clinical efficacy limited thus leading poor oral bioavailability. To address this issue, we encapsulated fucoxanthin in rhamnolipid fabricated bovine serum albumin (BSA) loaded nanoparticles (LNPs) for improving dependent bioavailability of fucoxanthin.These synthesized LNPs were characterized by dynamic light scattering (DLS), ultraviolet (UV)-visible...

10.1002/jsfa.11901 article EN Journal of the Science of Food and Agriculture 2022-03-31

Inspired by array of proteins present in nature, we choose lysozyme (hen egg protein) as a model system to synthesize nanoparticles noble metals understand the mechanism interaction well use them for potential applications such potent antibacterial agents. Lysozyme is very studied biomolecule containing aromatic amino acids like tryptophan and tyrosine. Tyrosine has phenoxy group which considered be responsible interacting with metal ions. can suitably modified treatment...

10.2174/1573413711208010130 article EN Current Nanoscience 2012-02-01

The study of elastic properties microbial and mammalian cells using atomic force microscopy, with force-sensitivity as high pico-Newtons spatial resolution a few nanometers, is proving to be great tool for the real-time observation effects drugs, biomolecules, metal ions, nanoparticles on cell physiology in their natural environment. It has been shown that Young's modulus surfaces extremely sensitive surrounding Recently, broad array microbes have used successfully synthesize nanocrystals...

10.1021/jp902698n article EN The Journal of Physical Chemistry B 2009-05-12
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