A5054716511- Hemoglobin structure and function
- Advanced Proteomics Techniques and Applications
- Traumatic Brain Injury and Neurovascular Disturbances
- Neurogenesis and neuroplasticity mechanisms
- Nerve injury and regeneration
- Neuroblastoma Research and Treatments
- Traumatic Brain Injury Research
- Axon Guidance and Neuronal Signaling
- Mitochondrial Function and Pathology
- S100 Proteins and Annexins
- Infective Endocarditis Diagnosis and Management
Arizona State University
2016-2022
The heterogeneous pathophysiology of traumatic brain injury (TBI) is a barrier to advancing diagnostics and therapeutics, including targeted drug delivery. We used unique discovery pipeline identify novel targeting motifs that recognize specific temporal phases TBI pathology. This combined in vivo biopanning with domain antibody (dAb) phage display, next-generation sequencing analysis, peptide synthesis. identified based on the complementarity-determining region 3 structure dAbs for acute (1...
The heterogeneous injury pathophysiology of traumatic brain (TBI) is a barrier to developing highly sensitive and specific diagnostic tools. Phage display, protein-protein screening technique routinely used in drug development, has the potential be powerful biomarker discovery tool for TBI. However, analysis these large diverse phage libraries bottleneck moving through pipeline timely efficient manner. This article describes unique involving domain antibody (dAb) vivo biopanning...
Abstract The heterogeneous injury pathophysiology of traumatic brain (TBI) is a barrier to developing highly sensitive and specific diagnostic tools. Embracing neural complexity critical for the development advancement diagnostics therapeutics. current study employs unique discovery pipeline identify targeting motifs that recognize phases TBI pathology. This entails in vivo biopanning with domain antibody (dAb) phage display library, next generation sequencing (NGS) analysis, peptide...