A5009520329- Alzheimer's disease research and treatments
- Congenital Heart Disease Studies
- Genetic Associations and Epidemiology
- Photochromic and Fluorescence Chemistry
- Congenital heart defects research
- Tissue Engineering and Regenerative Medicine
- Photodynamic Therapy Research Studies
- Porphyrin and Phthalocyanine Chemistry
- Genomic variations and chromosomal abnormalities
- Dementia and Cognitive Impairment Research
- Nonlinear Optical Materials Studies
- Bioinformatics and Genomic Networks
Maastricht University
2022-2025
Institute of Molecular Biology and Genetics
2018-2020
Background Late-onset Alzheimer's disease (LOAD) has been associated with alterations in the morphology of multiple brain structures, and it is likely that mechanisms differ between regions. Coupling genetic determinants LOAD measures could localize identify primary causal neurobiological pathways. Objective To determine pathways from risk variants via to LOAD. Methods Mediation Mendelian randomization (MR) analysis were performed using common variation, T1 MRI clinical data collected by UK...
Abstract Background: Copy Number Variations (CNVs) are structural variation in the genome, which may impact complex human traits and diseases. The investigation of rare CNVs is impeded by low sample size. To understand mechanisms through influence health, common genomic region CNV from large samples could be used as a proxy. Methods: Utilising genome-wide association study (GWAS) summary statistics 20 traits, we assessed cumulative effect genetic variants eight regions containing pathogenic...
INTRODUCTION: Late-onset Alzheimers disease (LOAD) has been associated with alterations in the morphology of multiple brain structures and it is likely that mechanisms differ between regions. Coupling genetic determinants LOAD measures could localize identify primary causal neurobiological pathways. METHODS: Mediation Mendelian randomization (MR) analysis were performed using common variation, T1 MRI clinical data collected by UK Biobank Disease Neuroimaging Initiative. RESULTS: Thickness...
Aim.To synthesize and characterize a series of N-alkylaryl benzothiazole styrylcyanine dyes as potential fluorescent probes for nucleic acids (NA) detection.Methods.Synthesis, absorption fluorescence spectroscopy, gel electrophoresis.Results.The modification N-alkyl by variation aromatic moieties insignificantly affected its inherent properties.Weakly in an unbound state, the noticeably increased their emission upon binding to dsDNA/RNA (up 83-fold derivative with N-alkylbenzylamine group...
Aim. Synthesis and characterization of benzothiazole-based styrylcyanines functionalized by different N-alkyl tail groups as potential photostable probes for nucleic acids (NA) detection.Methods.Chemical synthesis, absorption fluorescence spectroscopy, irradiation with a visible light source, confocal microscopy.Results.Styrylcyanines are weakly fluorescent when free, but in the presence NA they show emission intensity increase up to 83 times; most pronounced was observed dyes Sbt1 Sbt3...