A5090037320- Dermatologic Treatments and Research
- Nonmelanoma Skin Cancer Studies
- Advancements in Transdermal Drug Delivery
- Cutaneous Melanoma Detection and Management
- Microbial Inactivation Methods
- Cancer and Skin Lesions
- Plant tissue culture and regeneration
- Photoacoustic and Ultrasonic Imaging
- Bee Products Chemical Analysis
- Optical Coherence Tomography Applications
- Toxin Mechanisms and Immunotoxins
- Laser Applications in Dentistry and Medicine
- Insect and Pesticide Research
- Antimicrobial Resistance in Staphylococcus
- Anesthesia and Sedative Agents
- Colorectal Cancer Surgical Treatments
- Antibiotics Pharmacokinetics and Efficacy
- Hedgehog Signaling Pathway Studies
- Cutaneous lymphoproliferative disorders research
- Facial Rejuvenation and Surgery Techniques
- Ocular and Laser Science Research
- Diabetes and associated disorders
- Inflammatory Bowel Disease
- Transgenic Plants and Applications
- Diabetes Management and Research
Bispebjerg Hospital
2019-2024
Copenhagen University Hospital
2019-2024
Frederiksberg Hospital
2019-2023
University of Copenhagen
2017-2022
University of Southern Denmark
2015
Bleomycin exhibits antiproliferative effects desirable for use in dermato-oncology but topical is limited by its 1415 Da molar mass. Ablative fractional laser (AFL)-assisted drug delivery has been shown to enhance uptake skin. The aim of this study was with AFL deliver bleomycin into skin, quantify uptake, and visualize biodistribution mass spectrometry. In a Franz diffusion cell study, pig skin samples (n = 66) were treated (λ 10,600 nm), 5% density, 0, 5, 20, or 80 mJ/microbeam (mb) pulse...
Abstract Background and Objectives There is a growing need for effective topical treatments basal cell carcinoma (BCC). By altering the skin barrier, ablative fractional lasers (AFLs) enhance cutaneous uptake of synergistic chemotherapeutic agents, cisplatin, 5‐fluorouracil (5‐FU). In our recently reported clinical trial, AFL‐assisted delivery cisplatin 5‐FU showed favorable short‐term clearance rates 95% with good cosmetic results at 3 months. This follow‐up study assessed sustained tumor...
Abstract Background Ablative fractional CO 2 laser (AFL) is an established first‐line energy‐based treatment for acne scars. Microneedle radiofrequency (MNRF) emerging treatment, also targeting the skin in fractions. No studies have so far compared AFL with MNRF scars a direct controlled, side‐by‐side comparison. In this study, we and treatments randomized split‐face trial blinded response evaluation, objective measures, patient‐reported outcomes. Study Design/Materials Method Fifteen...
Introduction The rise in antimicrobial resistance is a major global concern and requires new treatment strategies. use of helper compounds, such as thioridazine (TDZ), an antipsychotic drug, combination with traditional antibiotics must be investigated. Objectives aim this study was to investigate the efficacy TDZ compound for dicloxacillin (DCX) against methicillin-resistant Staphylococcus aureus (MRSA) vivo, compare DCX+TDZ vancomycin (VAN). Methods Mice were inoculated intraperitoneal...
Background and Objectives Rising incidences of basal cell carcinoma (BCC) have increased the need for effective topical therapies. By enhancing cutaneous uptake chemotherapeutic agents, cisplatin 5‐fluorouracil (5‐FU), laser‐assisted delivery may provide a new combination treatment BCC. Accordingly, this study aimed to evaluate tumor response, safety, drug biodistribution in tumors blood after 5‐FU + CIS BCC patients. Study Design/Materials Methods This open‐label, proof‐of‐concept trial...
In electrochemotherapy, permeabilization of the cell membrane by electric pulses increases anti-tumour effect chemotherapeutics. calcium electroporation, chemotherapy is replaced chloride with obvious benefits. This study explores and underlying mechanisms electroporation on basal carcinomas using either high- or low-frequency electroporation. Low-risk primary were treated in local anaesthesia intratumoral followed high (167 kHz) low (5 frequencies. Non-complete responders retreated after 3...
Bleomycin (BLM) is being repositioned in dermato-oncology for intralesional and intra-tumoural use. Although conventionally administered by local needle injections (NIs), ablative fractional lasers (AFLs) can facilitate topical BLM delivery. Adding electroporation (EP) augment intracellular uptake the target tissue. Here, we characterize compare biodistribution patterns, cutaneous pharmacokinetic profiles, tolerability an vivo pig model following laser-assisted drug delivery intradermal NI,...
Background and Objectives Décolleté photodamage is a common condition typically treated with light energy‐based devices. This study investigated the efficacy safety of fractional 1,927 nm thulium laser (TL) alone combined photodynamic therapy (PDT). Study Design/Materials Methods In 12‐week follow‐up study, participant décolletés were divided into four treatment areas randomized to receive single field‐directed TL, PDT, combination TL‐PDT, or lesion‐directed curettage control. All actinic...
<b><i>Background and Objectives:</i></b> Image-guided quantitative semi-quantitative assessment of skin can potentially evaluate treatment efficacy. Optical coherence tomography (OCT) reflectance confocal microscopy (RCM) are ideal for this purpose. This study assessed clinically relevant statistical changes in RCM OCT features photoaged after light energy-based therapy. <b><i>Methods:</i></b> Novel analyses were performed using data collected...
We evaluated a new handheld stereoscopic imaging system capable of visualizing scars with digital three-dimensional (3D) models and providing automated morphometric estimates. The objective was to validate the repeatability accuracy intra- inter-investigator scan results.Engineered metal plates depressed elevated model (n = 72) were scanned six times by one investigator. In vivo hypertrophic atrophic 15) once three investigators. estimates assessed using coefficients variation (CVs) compare...
Abstract Background and Objectives Current cancer immunotherapeutic treatment with PD‐1 inhibitors is administered systemically. However, a local strategy may be advantageous as it could provide targeted drug delivery well attenuate side effects seen systemic treatments. For keratinocyte cancers, where surgical excision not always applicable, an alternate approach would beneficial. This study aims to examine cutaneous pharmacokinetics biodistribution of the inhibitor nivolumab, locally...
Intralesional bleomycin (BLM) administration by needle injection is effective for keloids and warts but has significant drawbacks, including treatment-related pain operator-depended success rates. Electronic pneumatic (EPI) a promising, less painful, needle-free method that potentially enables precise controlled dermal drug delivery. Here, we aimed to explore the cutaneous pharmacokinetics, biodistribution patterns, tolerability of BLM administered EPI in vivo.In pig model, with or saline...