A5115599582- Machine Learning in Bioinformatics
- Complement system in diseases
- Genomics and Phylogenetic Studies
- Chemokine receptors and signaling
- Glycosylation and Glycoproteins Research
- Protein Structure and Dynamics
Tsinghua University
2024
Tianjin Medical University Cancer Institute and Hospital
2013
The complement component 1, q subcomponent binding protein (C1QBP/p32/HABP1) is a ubiquitously expressed and multicompartmental cellular involved in various biological processes. In order to further understand its functions, we conducted proteomics analysis of interactome this study. An improved sample preparation mass spectrometric identification strategy was developed combining high-speed centrifugation, formaldehyde labeling, two-dimensional reverse-phase liquid chromatography. Using...
<title>Abstract</title> Designing enzyme sequences to enhance product yield represents a fundamental challenge in metabolic engineering. Here, we established workflow that integrates computational predictions with efficient experimental iteration obtain outsized gains yield. Based on causal inference and examination of published datasets from previous yield-boosting engineering efforts, realized ultimately experimentally confirmed <italic>in vivo</italic> unit (yield/expression) can serve as...