A5038925634- biodegradable polymer synthesis and properties
- Carbon dioxide utilization in catalysis
- Synthetic Organic Chemistry Methods
- Asymmetric Synthesis and Catalysis
- Asymmetric Hydrogenation and Catalysis
- Organometallic Complex Synthesis and Catalysis
- Microplastics and Plastic Pollution
- Microfluidic and Capillary Electrophoresis Applications
- Analytical Chemistry and Chromatography
- Chemical Synthesis and Analysis
- Chemical Synthesis and Reactions
- Synthesis and Catalytic Reactions
- Advanced Polymer Synthesis and Characterization
- Advanced Synthetic Organic Chemistry
- Advancements in Battery Materials
- Oxidative Organic Chemistry Reactions
- Recycling and Waste Management Techniques
- Chromatography in Natural Products
- Crystallization and Solubility Studies
- Chemical synthesis and alkaloids
- Advanced Battery Materials and Technologies
- Protein purification and stability
- X-ray Diffraction in Crystallography
- Catalytic Cross-Coupling Reactions
- Catalytic C–H Functionalization Methods
Qingdao Institute of Bioenergy and Bioprocess Technology
2017-2025
Chinese Academy of Sciences
2009-2025
University of Chinese Academy of Sciences
2019-2025
Qinghai New Energy (China)
2023-2025
Bristol-Myers Squibb (United States)
2011-2024
Sino-Danish Centre for Education and Research
2024
Wuhan University of Technology
2005-2024
China University of Mining and Technology
2024
Bristol-Myers Squibb (Germany)
2011-2024
Drexel University
2024
Phosphorothioate nucleotides have emerged as powerful pharmacological substitutes of their native phosphodiester analogs with important translational applications in antisense oligonucleotide (ASO) therapeutics and cyclic dinucleotide (CDN) synthesis. Stereocontrolled installation this chiral motif has long been hampered by the systemic use phosphorus(III) [P(III)]-based reagent systems sole practical means assembly. A fundamentally different approach is described herein: invention a...
Confined chiral Brønsted acids are shown to catalyze asymmetric oxidations of sulfides sulfoxides with hydrogen peroxide. The wide generality and high enantioselectivity the developed method compare even best metal-based systems suggest utility in other oxidations.
The design and synthesis of chemically recyclable polymers, which can be reutilized as their starting monomers or new value-added chemicals, has provided a practical approach to address the end-of-use problem polymer materials possible closed-loop method for material usage. More more attention been paid exhibit an increasing prominent role in sustainable development. Nowadays, polymers including polyesters, polythioesters, polycarbonates, polyacetals, polyamides, so on have made significant...
The commercial plastics that are currently used in large-scale primarily concerned with performance and durability, rather than degradability recyclability. As a result, the chemical recycling of becomes significant challenge. Selective depolymerization mixed plastic waste is promising solution to challenges caused by accumulation. Here we present sequential "one-pot" strategies for (PLA, BPA-PC, PBS, PBAT, PCL, PET) (BPA-PC/PET, PLA/PBS, PLA/PBAT) their initial monomers or value-added...
Plastics recycling has become an important issue based on the principle of sustainability and circular economy. Therefore, development a valuable chemical method, to achieve process end-of-life polylactide (PLA) waste without loss material properties, meets unprecedented opportunities. In this regard, we propose "DE–RE polymerization" strategy from PLA plastic new virgin-quality materials in "polymer polymer" mode. This approach improves efficiency promotes plastics reutilization.
Plastics are integral to numerous significant social advancements. Nonetheless, their contribution environmental pollution and climate crises cannot be disregarded, as negative impact on the environment increases with incremental production capacity demand. Concerted global action is urgently required promote green recycle of plastics prevent accumulation in mitigate carbon emissions. This review aims reveal paths development for polyester plastics, incorporating trends revolution mature...
Isotactic polymers have emerged with unique and excellent properties in material sciences. Specific discrimination polymerization provides an ideal pathway to achieve highly isotactic from their racemic monomers, which is of great significance a challenge polymeric chemistry. Although enantioselective catalyst-mediated asymmetric kinetic resolution (AKRP) process makes it possible, general well-defined strategy for catalyst design still rarely reported. Here, based on novel dual-ligand...
A highly efficient diastereoselective synthesis of cyclohexadiene epoxide derivatives with a multi-stereocenter has been developed via tandem ylide Michael addition/epoxidation. By employing chiral sulfonium ylide, up to 96% ee can be achieved in good yields.
An asymmetric Mannich reaction of silyl ketene acetals with N-Boc-amino sulfones has been developed. A chiral disulfonimide efficiently catalyzes both the in situ generation corresponding N-Boc imines and excellent yields enantioselectivities. Kinetic studies confirm a proposed stepwise mechanism.
Abstract An asymmetric Torgov cyclization, catalyzed by a novel, highly Brønsted acidic dinitro‐substituted disulfonimide, is described. The reaction delivers the diene and various analogues with excellent yields enantioselectivity. This method was applied in very short synthesis of (+)‐estrone.
The first catalytic enantioselective Abramov reaction is described. process based on the utilization of a chiral disulfonimide catalyst, which efficiently avoids difficulties encountered with metal-based catalysts. Several functionalized α-hydroxy phosphonates were synthesized in good yields and excellent enantiomeric ratios up to >99:1. was shown be scalable 1 g starting material could employed under mild conditions.
Zn(HMDS)2 as a simple, biocompatible, efficient, and supporting ligand-free metal catalyst has been achieved for polyesters synthesis degradation. The not only powerful capacity ring-opening polymerization of various lactones to obtain diverse sustainable polyesters, such poly(lactide), poly(3-hydroxybutyrate), poly(caprolactone), etc., with controlled molecular weights narrow weight distributions, but also can be used degrade into valuable depolymerization products excellent yields...
Chemical recycling of plastic wastes not only provides a practical pathway to solve the end-of-use issue polymer materials but also offers possible closed-loop approach for mainly fossil-based materials, which has drawn tremendous attention from academia and industry. Poly(bisphenol A carbonate) (BPA-PC), typical shock-resistant thermoplastic material, been used increasingly all over world, should receive extensive its potential environmental harm, as well chemical route. For BPA-PC,...
The first ε-CL polymerization/PCL depolymerization closed-loop chemical recycling process was developed under the catalysis of Mg(HMDS) 2 .
The chemical upcycling of poly(bisphenol A carbonate) (BPA-PC) by a catalyst-free amino-alcoholysis depolymerization protocol was achieved.
The synthesis of stereoregular aliphatic polyesters with superior (bio)degradability and recyclability has been one the promising areas in material science, which can be achieved through stereoselective polymerization cyclic esters. However, it remains a long-standing challenge to achieve tacticity (isotactic heterotactic) control catalytic system modulation mechanism. Here we reported tunable controllable method for racemic n-propylglycolide (nPrgl) based on analysis enantiomorphic site...
Abstract An organocatalytic asymmetric synthesis of δ‐amino‐β‐ketoester derivatives has been developed. A chiral disulfonimide (DSI) serves as a highly efficient precatalyst for vinylogous Mukaiyama–Mannich reaction readily available dioxinone‐derived silyloxydienes with N‐Boc‐protected imines, delivering products in excellent yields and enantioselectivities. The synthetic utility this is illustrated various transformations, including new CC bond‐forming reaction, which provide useful...
Developing a new approach for synthesizing block polymers is highly demanded. Herein, we propose sequential transesterification strategy to synthesize in "polymer polymer" mode, such as PLA–PCL–PLA triblock copolymers, by exploiting differences rates between different polymers. Poly(ε-caprolactone) (PCL) was first controllably cleaved an α,ω-hydroxyl-terminated macroinitiator (HO-PCL-OH) with defined molecular weights employing 1,5,7-triazabicyclo[4,4,0]dec-5-ene (TBD) organocatalyst and...
Plasticizers are essential to reduce processing difficulties and improve plastic properties. However, petroleum-based phthalate plasticizers, which mostly used at present, urgently require alternatives due their confirmed serious health risks. In this study, the green mass production of trans-aconitic acid was achieved via synthetic biotechnology microbial fermentation, further expanded multiple application scenarios using chemical esterification, resulting in trans-aconitate plasticizers...
A series of iminopyridine complexes Fe(II) and Co(II) bearing fluorinated aryl substituents were synthesized for the polymerization isoprene. The structures 3a, 2b 3b determined by X-ray diffraction analysis. Complex 3a contained two ligands coordinated to iron metal center forming an octahedral geometry, whereas adopted a chloro-bridged dimer, featured with patterns cobalt centers bridged via chlorine atoms. Complexes represented rare examples bimetallic complexes. fluorine effects,...