A5010281753- Polyamine Metabolism and Applications
- Advanced NMR Techniques and Applications
- Crystallography and molecular interactions
- DNA and Nucleic Acid Chemistry
- Chemical Synthesis and Analysis
- Solid-state spectroscopy and crystallography
- X-ray Diffraction in Crystallography
- Mass Spectrometry Techniques and Applications
- Crystallization and Solubility Studies
- Antimicrobial agents and applications
- Carbohydrate Chemistry and Synthesis
- Molecular spectroscopy and chirality
- Analytical Chemistry and Chromatography
- NMR spectroscopy and applications
Daiichi-Sankyo (Japan)
2016-2017
University of Warwick
2012-2017
Daiichi Sankyo (Germany)
2012
Zero to Three
2011
Osaka University
2004-2011
Two-dimensional 1H double-quantum and 14N–1H & 1H–13C heteronuclear magic-angle spinning (MAS) NMR spectra recorded at natural isotopic abundance identify specific intermolecular COOH⋯Narom CHarom⋯OC hydrogen-bonding interactions in the solid-state structure of an indomethacin–nicotinamide cocrystal, thus additionally proving cocrystal formation.
We report the crystal structure of anhydrous phase cimetidine hydrochloride, determined directly from powder X-ray diffraction data. The material was prepared by dehydration readily obtained monohydrate form only for which a has previously been reported. As such, solid-state processes typically yield product as microcrystalline powder, and determination carried out data, using direct-space genetic algorithm technique solution followed Rietveld refinement. further validated calculating 13C...
The lower detection limit for 2 distinct crystalline phases by 1H magic-angle spinning (MAS) solid-state nuclear magnetic resonance (NMR) is investigated a minority amount of cimetidine (anhydrous polymorph A) in physical mixture with the anhydrous HCl salt cimetidine. Specifically, 2-dimensional double-quantum (DQ) MAS NMR spectra A and constitute fingerprints presence each these solid forms. For data recorded at Larmor frequency 850 MHz 30 kHz on ∼10 mg sample, it shown that, following...
Endogenous polyamines, represented by putrescine, spermidine, and spermine, are known to exert their physiological functions interacting with polyanionic biomolecules such as DNA, RNA, adenosine triphosphate (ATP), phospholipids. Very few examples of conformation analysis have been reported for these highly flexible polymethylene compounds, mainly due the lack appropriate methodologies. To understand molecular basis weak interaction between polyamines polyanions that underlies functions, we...
Selectively (2)H- and (13)C-labeled spermines (SPM) were efficiently synthesized analyzed by NMR spectroscopy to determine the spin-spin coupling constants for six conformationally relevant bonds. SPM that is composed of three alkyl moieties, a butanylene, two propanylene chains undergoes conformational change when interacting with multivalent anions (e.g., adenosine triphosphate (ATP), ATP-Mg(2+) , tripolyphosphate). Upon interaction ATP, C-C bonds, which affect distance between neighboring...
Abstract Vicinal spin–spin coupling constants frequently used for conformation analysis were determined ammonium-containing 13C–N–C–1H systems by using HMBC. 1-Deoxynojirimycin hydrochloride provided an appropriate system measuring the antiperiplanar and gauche interactions, which to be 7.3 1.6 Hz, respectively.