A5024021489- Redox biology and oxidative stress
- Environmental Education and Sustainability
- Sustainability in Higher Education
- Heat shock proteins research
- DNA Repair Mechanisms
- Neutrophil, Myeloperoxidase and Oxidative Mechanisms
- Estrogen and related hormone effects
- Glutathione Transferases and Polymorphisms
- Genomics and Chromatin Dynamics
- Retinoids in leukemia and cellular processes
- Protein Tyrosine Phosphatases
- Sustainable Building Design and Assessment
- Sulfur Compounds in Biology
- CRISPR and Genetic Engineering
- Parkinson's Disease Mechanisms and Treatments
- Endoplasmic Reticulum Stress and Disease
- Service-Learning and Community Engagement
- Climate Change Communication and Perception
- Neurological disorders and treatments
- Education and Critical Thinking Development
- Bioactive Compounds and Antitumor Agents
- Genomics, phytochemicals, and oxidative stress
- Vitamin C and Antioxidants Research
- Transcranial Magnetic Stimulation Studies
- Lysosomal Storage Disorders Research
University of Otago
2016-2025
HAW Hamburg
2024
Institut de Mathématiques de Toulouse
2024
University of Malta
2013-2023
San Salvatore Hospital
2022
MRC Laboratory of Molecular Biology
2002-2010
Medical Research Council
2005-2008
Istituti di Ricovero e Cura a Carattere Scientifico
2002-2006
Imperial College London
1999-2004
Hammersmith Hospital
2000-2004
Purpose – This paper aims to provide a description of the achievements United Nations (UN) Decade Education for Sustainable Development (2005-2014) with focus on higher education, and it describes some key issues which will guide sustainable development in coming years. Design/methodology/approach The initially presents an analysis past developments, complemented by assessment emphasis International Journal Sustainability Higher . In particular, makes cross-references deliberations held at...
The United Nations Sustainable Development Goals (UN SDGs) contain a set of 17 measures to foster sustainable development across many areas. It offers good opportunity reinvigorate research for two main reasons. First, it comprises areas SD research, which have become mainstream thanks the UN SDGs. Second, fact that and its member countries committed attaining SDGs by 2030 has added sense urgency need perform quality on one hand, reiterates use results this other. Even though basic concept...
Phosphorylation provides an important mechanism by which transcription factor activity is regulated. Estrogen receptor α (ERα) phosphorylated on multiple sites, and stimulation of a number growth receptors and/or protein kinases leads to ligand-independent synergistic increase in transcriptional activation ERα the presence estrogen. Here we show that kinase A (PKA) serine-236 within DNA binding domain. Mutation glutamic acid prevents inhibiting dimerization ERα, whereas mutation alanine has...
Righting Repair Pathways The genetic disease Fanconi anemia (FA) results from mutations in a series of genes involved DNA repair pathway that helps process the damage caused by erroneous chemical cross-links between two strands double helix. double-stranded breaks arise such can be repaired an error-free manner or through error-prone pathway. Pace et al. (p. 219 , published online 10 June) show FA drive FANCC gene shows interaction with component pathway, Ku70, inhibiting its action and...
Monoubiquitination of FANCD2 and PCNA promotes DNA repair. It causes chromatin accumulation facilitates PCNA's recruitment translesion polymerases to stalled replication. USP1, a protease that removes monoubiquitin from PCNA, was thought reverse the damage response these substrates. We disrupted USP1 in chicken cells dissect its role stable genetic system. ablation increases monoubiquitination but unexpectedly results crosslinker sensitivity. This defective repair is associated with...
Peroxiredoxin 2 (Prx2) is a thiol protein that functions as an antioxidant, regulator of cellular peroxide concentrations, and sensor redox signals. Its cycle widely accepted to involve oxidation by reduction thioredoxin/thioredoxin reductase. Interactions Prx2 with other thiols are not well characterized. Here we show the active site Cys residues form stable mixed disulfides glutathione (GSH). Glutathionylation was reversed glutaredoxin 1 (Grx1), GSH plus Grx1 able support peroxidase...
The COVID-19 pandemic has caused a global crisis, one which also influences the ways sustainability is being taught at universities. This paper undertakes an analysis of extent to as whole and lockdown it triggered in particular, led suspension presence-based teaching universities worldwide influenced on matters related sustainable development. By means survey involving higher education institutions across all continents, study identified number patterns, trends problems. results from show...
Universities have an unrivaled potential to educate students on climate change issues and actively engage them in affairs, both as citizens influencers of future professions. Despite this the many advantages university student engagement change, less emphasis has been given understanding their attitude perceptions towards a way that may guide changes curriculum teaching practices. Based need address existing literature gap, article assesses studentś attitudes toward at international level....
Peroxiredoxins (Prx) are thiol peroxidases that exhibit exceptionally high reactivity toward peroxides, but the chemical basis for this is not well understood. We present strong experimental evidence two highly conserved arginine residues play a vital role in activity of human Prx2 and Prx3. Point mutation either ArgI or ArgII (in Prx3 Arg-123 Arg-146, which ∼3-4 Å ∼6-7 away from active site peroxidative cysteine (C(p)), respectively) each case resulted 5 orders magnitude loss reactivity. A...
Protein-tyrosine phosphatases (PTPs) counteract protein tyrosine phosphorylation and cooperate with receptor-tyrosine kinases in the regulation of cell signaling. PTPs need to undergo oxidative inhibition for activation cellular cascades protein-tyrosine kinase following growth factor stimulation. It has remained enigmatic how such oxidation can occur presence potent reducing systems. Here, using vitro biochemical assays purified, recombinant protein, along experiments adenocarcinoma line...
Glyceraldehyde-3-phosphate dehydrogenase (GAPDH) contains an active site Cys and is one of the most sensitive cellular enzymes to oxidative inactivation redox regulation. Here, we show that by hydrogen peroxide strongly enhanced in presence carbon dioxide/bicarbonate. Inactivation isolated mammalian GAPDH H 2 O increased with increasing bicarbonate concentration was sevenfold faster 25 mM (physiological) compared bicarbonate-free buffer same pH. reacts reversibly CO form a more reactive...