A5045652998- Essential Oils and Antimicrobial Activity
- Phytochemistry and Biological Activities
- Natural product bioactivities and synthesis
- Mercury impact and mitigation studies
- Nanoparticles: synthesis and applications
- Phytochemistry and Bioactive Compounds
- Mining and Resource Management
- Quantum Dots Synthesis And Properties
- Arsenic contamination and mitigation
- Sulfur-Based Synthesis Techniques
- Heavy Metals in Plants
- Allelopathy and phytotoxic interactions
- Plant chemical constituents analysis
- Carbon and Quantum Dots Applications
- Mine drainage and remediation techniques
- Computational Drug Discovery Methods
- Seed and Plant Biochemistry
- Catalytic C–H Functionalization Methods
- Nanocluster Synthesis and Applications
- PI3K/AKT/mTOR signaling in cancer
- Heavy Metal Exposure and Toxicity
- Protein Interaction Studies and Fluorescence Analysis
- Nanoparticle-Based Drug Delivery
- Natural Antidiabetic Agents Studies
- Catalytic Cross-Coupling Reactions
North East Institute of Science and Technology
2016-2023
Academy of Scientific and Innovative Research
2019
Background: Cancer is a grave health problem for the world as global cancer burden rises to 14 million new cases with 8.2 deaths every year which expected rise by 70% in next 2 decades reported WHO.These steady death demand rapid developments anti-cancer agents. Essential oils, being natural and multi-component complex systems have recently attracted lot of attention this search novel Materials Methods: The pharmaceutical attributes essential oil components, specifically focusing on their...
Abstract Arsenic is a global health concern at present and it well reported for causing systemic toxicity. It also known generation of free radical inducing apoptosis in different cell types. Paradoxically arsenic to be susceptible carcinogen as well. There are several reports demonstrating diverse mechanism However, the universal scenario instrumental genes their interaction leading amplification apoptotic signal yet completely uncovered, which predicted here. Conventional studies on...
Eurya acuminata DC and Croton caudatus Gieseler are two ethno-medicinal plants used by Kuki community of North East India. From these plants, we have characterized fifteen phytochemicals (1-15) extensive use chromatographic spectroscopic methods. They were also tested for in vitro cytotoxic effects against A549 MIAPACA2 cell lines antimicrobial activities Mycobacterium smegmatis Candida albicans. All compounds showed moderate activity the lines. Compounds tricosan-1-ol (6), octacosanoic acid...
Abstract Elsholtzia communis (Collett & Hemsl.) Diels (family: Lamiaceae) is a wild edible plant employed as remedy for skin irritation and consumed vegetables by the indigenous tribes of North East, India. In view its traditional uses, our present study aims to characterize chemical constituents essential oil isolated from leaf E evaluate antimicrobial, cytotoxic, antioxidant angiotensin‐I‐converting enzyme inhibiting properties. GC‐FID GC‐MS analyses led identification fifty‐one...
Gnetum gnemon L. (Gnetaceae) is used traditionally for treating malaria related fever by indigenous people of North East India. In our preliminary study, the ethanol extract G. leaves showed promising antiplamodial activity against Plasmodium falciparum chloroquine sensitive (3D7) strain in vitro with an IC 50 value 29.4 μg/mL. Therefore, it was further investigated, and following a bioassay guided approach, 2,3-dihydroxypropyl icosanoate (1), oleic acid (2) ursolic (3) were isolated first...
Synthesis, characterization, and applications of strongly fluorescent, multicolored protein nanoparticles (GlowDots) are reported here. Bovine serum albumin was cross-linked under controlled conditions to form nanoparticles, where particle size from 20 100 ± 10 nm by choosing appropriate reaction conditions. The absorption as well the emission wavelengths were without changing size, unlike quantum dots. Each GlowDot loaded with up 214 50 chromophores, hence, particles have high molar...
In this study essential oil from Oldenlandia diffusa (aerial parts) was extracted using hydrodistillation method. Characterization of the done by GC-MS analysis and identified 71 compounds. Pentacosane (13.29%), hexacosane (11.59%), tetracosane (11.18%), heptacosane (9.76%),tricosane (6.90%), phytol (5.71%), hexatriacontane (4.87%) isophytol (4.69%) were major compounds constituting oil. Further, cytotoxicity observed against PA1 (Ovarian), MIAPaCa-2 (Pancreatic), A549 (Lung), MCF7 (Breast),...
With the objective to identify novel anticancer leads, herein ruthenium-catalyzed electrochemical homo- and heterocoupling reactions of terminal alkynes have been developed for synthesis desired products. Among synthesized 1,3-diynes, some them were rigorously examined possible in vitro activity against HeLa (human cervical cancer) L6 normal (rat skeletal muscle) cell lines. Additionally, docking study was also performed toward 16 ovarian cancer targets with binding affinity calculations...